2. Apoptosis
  3. Apoptosis Caspase
  4. β-Santalol

β-Santalol is a sesquiterpene alcohol with apoptosis (apoptosis)-inducing activity and cytotoxic activity. β-Santalol activates caspase-3, induces nuclear chromatin condensation, and promotes the formation of apoptotic bodies. β-Santalol targets cancer cells. β-Santalol can be used in research related to promyelocytic leukemia, lung adenocarcinoma, and oral squamous cell carcinoma.

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β-Santalol

β-Santalol Chemical Structure

CAS No. : 77-42-9

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β-Santalol Related Antibodies

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Description

β-Santalol is a sesquiterpene alcohol with apoptosis (apoptosis)-inducing activity and cytotoxic activity. β-Santalol activates caspase-3, induces nuclear chromatin condensation, and promotes the formation of apoptotic bodies. β-Santalol targets cancer cells. β-Santalol can be used in research related to promyelocytic leukemia, lung adenocarcinoma, and oral squamous cell carcinoma[1][2].

IC50 & Target[2]

Caspase 3

 

Cellular Effect
Cell Line Type Value Description References
CAL-27 GI50
5.7 μM
Compound: beta-santalol
Growth inhibition of human CAL27 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human CAL27 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
HN5 GI50
6.3 μM
Compound: beta-santalol
Growth inhibition of human HN5 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HN5 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
HSC-2 GI50
7.3 μM
Compound: beta-santalol
Growth inhibition of human HSC2 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HSC2 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
HSC-3 GI50
4.4 μM
Compound: beta-santalol
Growth inhibition of human HSC3 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human HSC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
SCC-25 GI50
4.2 μM
Compound: beta-santalol
Growth inhibition of human SCC25 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SCC25 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
SCC-4 GI50
5.8 μM
Compound: beta-santalol
Growth inhibition of human SCC4 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SCC4 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
SCC-9 GI50
4.2 μM
Compound: beta-santalol
Growth inhibition of human SCC9 cells after 48 hrs by sulforhodamine B assay
Growth inhibition of human SCC9 cells after 48 hrs by sulforhodamine B assay
[PMID: 25993496]
In Vitro

β-Santalol (Compound 9) (0-40 μM; 72 h) inhibits the growth of HL-60, A549, HSC-2 and HSC-4 tumor cells with IC50 values ranging from 9.9 to 39.3 μM, but exerts no effect on the growth of normal TIG-3 cells even at the highest concentration of 40 μM[2].
β-Santalol (40 μM; 24 h) induces chromatin condensation and apoptotic body formation in HL-60 cells[2].
β-Santalol (40 μM; 16 h) activates caspase-3 in HL-60 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Santalol Related Antibodies

Cell Cytotoxicity Assay[2]

Cell Line: HL-60 cells, A549 cells, HSC-2 and HSC-4 cells, TIG-3 normal human diploid fibroblasts
Concentration: 0-40 μM
Incubation Time: 72 h
Result: Exhibited cytotoxic activity against HL-60 cells with an IC50 of 9.9 μM.
Exhibited cytotoxic activity against A549 cells with an IC50 of 39.3 μM.
Exhibited cytotoxic activity against HSC-2 cells with an IC50 of 11.0 μM.
Exhibited cytotoxic activity against HSC-4 cells with an IC50 of 17.7 μM.
Did not inhibit the growth of TIG-3 normal cells at concentrations up to 40 μM, resulting in an IC50 value >40 μM.

Apoptosis Analysis[2]

Cell Line: HL-60 human promyelocytic leukemia cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Induced nuclear chromatin condensation and apoptotic bodies in HL-60 cells.
Molecular Weight

220.36

Formula

C15H24O
CAS No.
SMILES

C(C/C=C(\CO)/C)[C@]1(C)[C@@]2(C[C@](C1=C)(CC2)[H])[H]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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β-Santalol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Santalol77-42-9ApoptosisCaspasehuman promyelocytic leukemiaapoptotic body formationEucarya spicata Sprague & Summ.caspase-3nuclear chromatin condensationcancer cellsHL-60Helicobacter pylorinormal human diploid fibroblastsSantalum albumInhibitorinhibitorinhibit

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