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Cat. No.: HY-N11764

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β-Santalol

β-Santalol is a sesquiterpene alcohol with apoptosis (apoptosis)-inducing activity and cytotoxic activity. β-Santalol activates caspase-3, induces nuclear chromatin condensation, and promotes the formation of apoptotic bodies. β-Santalol targets cancer cells. β-Santalol can be used in research related to promyelocytic leukemia, lung adenocarcinoma, and oral squamous cell carcinoma.

For research use only. We do not sell to patients.

CAS No.: 77-42-9
Formula: C₁₅H₂₄O
Molecular Weight:220.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

β-Santalol Chemical Structure

CAS No.: 77-42-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

Caspase 3

All Caspase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CAL-27	GI₅₀	5.7 μM Compound: beta-santalol	Growth inhibition of human CAL27 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human CAL27 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]
HN5	GI₅₀	6.3 μM Compound: beta-santalol	Growth inhibition of human HN5 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HN5 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]
HSC-2	GI₅₀	7.3 μM Compound: beta-santalol	Growth inhibition of human HSC2 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HSC2 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]
HSC-3	GI₅₀	4.4 μM Compound: beta-santalol	Growth inhibition of human HSC3 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human HSC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]
SCC-25	GI₅₀	4.2 μM Compound: beta-santalol	Growth inhibition of human SCC25 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SCC25 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]
SCC-4	GI₅₀	5.8 μM Compound: beta-santalol	Growth inhibition of human SCC4 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SCC4 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]
SCC-9	GI₅₀	4.2 μM Compound: beta-santalol	Growth inhibition of human SCC9 cells after 48 hrs by sulforhodamine B assay Growth inhibition of human SCC9 cells after 48 hrs by sulforhodamine B assay	[PMID: 25993496]

In Vitro

β-Santalol (Compound 9) (0-40 μM; 72 h) inhibits the growth of HL-60, A549, HSC-2 and HSC-4 tumor cells with IC₅₀ values ranging from 9.9 to 39.3 μM, but exerts no effect on the growth of normal TIG-3 cells even at the highest concentration of 40 μM^[2].
β-Santalol (40 μM; 24 h) induces chromatin condensation and apoptotic body formation in HL-60 cells^[2].
β-Santalol (40 μM; 16 h) activates caspase-3 in HL-60 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[2]

Cell Line:

HL-60 cells, A549 cells, HSC-2 and HSC-4 cells, TIG-3 normal human diploid fibroblasts
Concentration:

0-40 μM
Incubation Time:

72 h
Result:

Exhibited cytotoxic activity against HL-60 cells with an IC₅₀ of 9.9 μM.
Exhibited cytotoxic activity against A549 cells with an IC₅₀ of 39.3 μM.
Exhibited cytotoxic activity against HSC-2 cells with an IC₅₀ of 11.0 μM.
Exhibited cytotoxic activity against HSC-4 cells with an IC₅₀ of 17.7 μM.
Did not inhibit the growth of TIG-3 normal cells at concentrations up to 40 μM, resulting in an IC₅₀ value >40 μM.

Apoptosis Analysis^[2]

Cell Line:

HL-60 human promyelocytic leukemia cells
Concentration:

40 μM
Incubation Time:

24 h
Result:

Induced nuclear chromatin condensation and apoptotic bodies in HL-60 cells.

Chemical Information

CAS No. 77-42-9
Molecular Weight 220.36
Formula C₁₅H₂₄O
SMILES

C(C/C=C(\CO)/C)[C@]1(C)[C@@]2(C[C@](C1=C)(CC2)[H])[H]
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Birch A, et al. (1953) The sesquiterpene Alcohols of Eucarya spicata Sprague & Summ. Australian Journal of Chemistry 6, 391–394.

[2]. Matsuo Y, et al. A rare type of sesquiterpene and β-santalol derivatives from Santalum album and their cytotoxic activities. Chem Pharm Bull (Tokyo). 2014;62(12):1192-1199. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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β-Santalol

All Caspase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

β-Santalol Related Classifications

HY-N11764 Related Classifications