Germanicol
Based on 1 Customer Validation
Germanicol is a selective antineoplastic agent against human colon cancer cell lines HCT-116 and HT29 . Germanicol induces apoptosis via chromatin condensation and DNA damage.
For research use only. We do not sell to patients.
- Purity: 99.0%
- CAS No.: 465-02-1
- Formula: C30H50O
- Molecular Weight:426.72
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Germanicol (0-100 µM; 6 h and 24 h) shows selective, potent and dose-dependent cytotoxicity in HCT-116 and HT29 human colon cancer cells. Germanicol induces HCT-116 and HT29 cells death in a dose-dependent manner[1].
Germanicol (0-100 µM; 48 h) induces HCT-116 colon cancer cells apoptosis in a dose-dependent manner[1].
Germanicol (0-100 µM; 0-48 h) inhibits HCT-116 colon cancer cells migration[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human colon cancer cell lines HCT-116 (colon), HT29 (colon) and Human colon fibroblast (CCD-18Co).
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Concentration:0, 5, 10, 20, 40 and 100 µM.
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Incubation Time:6 h and 24 h.
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Result:Showed insignificant cytotoxicity below 20 μM and exhibited potent and dose-dependent cytotoxic effect on both HCT-116 and HT29 colon cancer cells at higher doses over 40 µM.
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Cell Line:HCT-116 colon cancer cells.
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Concentration:0, 10, 40 and 100 µM.
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Incubation Time:48 h.
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Result:Induced potent and dose-dependent chromatin condensation, accompanied by subsequent DNA damage.
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Cell Line:HCT-116 colon cancer cells.
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Concentration:0, 10, 40 and 100 µM.
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Incubation Time:0, 12, 24 and 48 h.
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Result:Decreased cell migration tendency.
Chemical Information
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CAS No. 465-02-1
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Appearance Solid
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Molecular Weight 426.72
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Formula C30H50O
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Color White to off-white
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SMILES
CC1(C)[C@@H](O)CC[C@]2(C)[C@@]3([H])CC[C@]4([H])C5=CC(C)(C)CC[C@@](C)5CC[C@](C)4[C@@](C)3CC[C@@]12[H]
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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