1. Antibody-drug Conjugate/ADC Related
    Apoptosis
  2. ADC Cytotoxin
    Apoptosis
    Caspase
  3. Duocarmycin A

Duocarmycin A 

Cat. No.: HY-12455
Handling Instructions

Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels.

For research use only. We do not sell to patients.

Duocarmycin A Chemical Structure

Duocarmycin A Chemical Structure

CAS No. : 118292-34-5

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Description

Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

IC50 & Target[1]

Procaspase-3

 

Caspase-9

 

Duocarmycins

 

Molecular Weight

507.49

Formula

C₂₆H₂₅N₃O₈

CAS No.

118292-34-5

SMILES

O=C([[email protected]@](N1)(C)C(C([[email protected]@]23[[email protected]@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)=O)OC

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Duocarmycin A
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