cone

By Targets:	Apoptosis (2) Biochemical Assay Reagents (1) GABA Receptor (1) iGluR (1) Sodium Channel (3)
By Research Areas:	Cancer (2) Neurological Disease (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122966

Desmethylxanthohumol 1 Publications Verification	Apoptosis	Cancer
Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .

HY-P5862

µ-Conotoxin BuIIIB Mu-Conotoxin BuIIIB	Sodium Channel	Neurological Disease
μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB) is a mammalian neuronal voltage-gated sodium channel (VGSC) blocker. μ-Conotoxin BuIIIB can be obtained from the venom of Cone snails and is a probe for ion channel function research. μ-Conotoxin BuIIIB can be used in the study of neurological diseases such as pain .

HY-P5864

µ-Conotoxin BuIIIA	Sodium Channel	Neurological Disease
μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA) is a voltage-gated sodium channel (VGSC) blocker. μ-Conotoxin BuIIIA is a toxic peptide that can be obtained from the venom of Cone snails. μ-Conotoxin BuIIIA can be used in the study of neurological diseases .

HY-N3612A

trans-Communic acid (-)-Communic acid	Others	Others
trans-Communic acid is a diterpenoid. trans-Communic acid can be isolated from ethyl acetate extract of young cones of hinoki (Chamaecyparis obtusa Endl.) .

HY-P2700

µ-Conotoxin GIIIB	Sodium Channel	Neurological Disease
μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a Na_V1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction .

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .

HY-N11976

Glycyrrhizin-6′′-methylester	Others	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-N7178

Abieta-8,11,13-triene-7α,15,18-triol	Others	Others
Abieta-8,11,13-triene-7α,15,18-triol is an abietane diterpene. Abieta-8,11,13-triene-7α,15,18-triol can be isolated from the CHCl₃ extract of the cones of Larix koempferi .

HY-N2787

8-Prenylnaringenin 1 Publications Verification	Apoptosis	Cancer
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice .

HY-N1659

2,3-Dihydropodocarpusflavone A

Others Others

2,3-Dihydropodocarpusflavone A is a biflavonoid, which can be isolated from Cycas beddomei .

2,3-Dihydropodocarpusflavone A	Others	Others
2,3-Dihydropodocarpusflavone A is a biflavonoid, which can be isolated from Cycas beddomei .

HY-P2325

Exoenzyme C3, clostridium botulinum	Biochemical Assay Reagents	Neurological Disease
Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration .

HY-103511

TCS1105	GABA Receptor	Neurological Disease
TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion .

Cat. No.	Product Name

HY-L143

Marine-Sourced Natural Product Library	40 compounds
Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria. Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union. MCE offers a unique collection of 40 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Marine-Sourced Natural Product Library

40 compounds

Oceans cover more than 70% of the Earth’s surface and host a huge species diversity. Marine organisms are considered the most recent source of bioactive natural products after terrestrial plants and nonmarine microorganisms. Marine biological sources are taxonomically diverse and include sponges, tunicates, corals, mollusks, fungi, and sediment-derived bacteria.

Marine organisms can produce a plethora of small molecules with novel chemical structures and potent biological properties, being a rich source for the discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Ziconotide, a peptide originally discovered in a tropical cone snail, was the first marine-derived compound to be approved in the United States in December 2004 for the treatment of pain. Then, in October 2007, Trabectedin became the first marine anticancer drug to be approved in the European Union.

MCE offers a unique collection of 40 marine-sourced natural products which can be used for drug discovery for high throughput screening (HTS) and high content screening (HCS). MCE marine-sourced natural product library is an important source for drug discovery and development.

Cat. No.	Product Name	Type

HY-P2325

Exoenzyme C3, clostridium botulinum	Biochemical Assay Reagents
Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration .

Cat. No.	Product Name	Target	Research Area

HY-P5862

µ-Conotoxin BuIIIB Mu-Conotoxin BuIIIB	Sodium Channel	Neurological Disease
μ-Conotoxin BuIIIB (Mu-Conotoxin BuIIIB) is a mammalian neuronal voltage-gated sodium channel (VGSC) blocker. μ-Conotoxin BuIIIB can be obtained from the venom of Cone snails and is a probe for ion channel function research. μ-Conotoxin BuIIIB can be used in the study of neurological diseases such as pain .

HY-P5864

µ-Conotoxin BuIIIA	Sodium Channel	Neurological Disease
μ-Conotoxin BuIIIA (Mu-Conotoxin BuIIIA) is a voltage-gated sodium channel (VGSC) blocker. μ-Conotoxin BuIIIA is a toxic peptide that can be obtained from the venom of Cone snails. μ-Conotoxin BuIIIA can be used in the study of neurological diseases .

HY-P2700

µ-Conotoxin GIIIB	Sodium Channel	Neurological Disease
μ-Conotoxin GIIIB is a 22-residue polypeptide that can be isolated from the venom of piscivorous cone snail Conus geographus. μ-Conotoxin GIIIB is a Na_V1.4 channel inhibitor. μ-Conotoxin GIIIB blocks muscle cell's contraction .

HY-P1287

Conantokin-T	iGluR	Neurological Disease
Conantokin-T is a γ-carboxyglutamate-containing, N-methyl-D-aspartate (NMDA) antagonist peptidewith an IC₅₀ value of 2 μM. Conantokin-T inhibits NMDA receptor-mediated calcium influx in central nervous system neurons. Conantokin-T can be purified from the venom of the fish-hunting cone snail, Conus tulipa .

HY-P2325

Exoenzyme C3, clostridium botulinum	Biochemical Assay Reagents	Neurological Disease
Exoenzyme C3, clostridium botulinum is a promising agent to inactivate RhoA in neurons due to preventing the detrimental effect of active Rho in the recovery of injured neuronal systems. Exoenzyme C3, clostridium botulinum is used for the study of post-traumatic neuro-regeneration .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122966

Desmethylxanthohumol 1 Publications Verification	Structural Classification Chalcones Flavonoids Classification of Application Fields Humulus lupulus L. Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Apoptosis
Desmethylxanthohumol is a prenylated hydroxychalcone isolated from hop cones (Humulus lupulus L.). Desmethylxanthohumol is a powerful apoptosis inducing agent. Desmethylxanthohumol has antiplasmodial, antiproliferative, and antioxidant bioactivities .

HY-N2787

8-Prenylnaringenin 1 Publications Verification	Flavonoids Classification of Application Fields Humulus lupulus L. Flavonones Source classification Phenols Polyphenols Plants Moraceae Disease Research Fields Cancer	Apoptosis
8-prenylnaringenin is a prenylflavonoid isolated from hop cones Humulus lupulus, with cytotoxicity. 8-prenylnaringenin has anti-proliferative activity against HCT-116 colon cancer cells via induction of intrinsic and extrinsic pathway-mediated apoptosis. 8-Prenylnaringenin also promotes recovery from immobilization-induced disuse muscle atrophy through activation of the Akt phosphorylation pathway in mice .

HY-N3612A

trans-Communic acid (-)-Communic acid	Structural Classification Cupressaceae Terpenoids Sesquiterpenes Source classification Plants Chamaecyparis obtusa	Others
trans-Communic acid is a diterpenoid. trans-Communic acid can be isolated from ethyl acetate extract of young cones of hinoki (Chamaecyparis obtusa Endl.) .

HY-N11976

Glycyrrhizin-6′′-methylester	Structural Classification Glycyrrhiza glabra Linn. Leguminosae Ketones, Aldehydes, Acids Source classification Plants	Others
Glycyrrhizin-6′′-methylester (compound 22) is a glycyrrhizin that can be isolated from licorice root. Glycyrrhizin-6′′-methylester can participate as an aglycone in the formation of methyl glucuronate, producing a sweet and licorice taste, but no bitterness. This reveals the importance of the free carboxyl group on the glycoside cone-bound glucuronic acid for natural sweetness and licorice taste .

HY-N7178

Abieta-8,11,13-triene-7α,15,18-triol	Structural Classification Pinaceae Pinus yunnanensis Franch. Terpenoids Source classification Diterpenoids Plants	Others
Abieta-8,11,13-triene-7α,15,18-triol is an abietane diterpene. Abieta-8,11,13-triene-7α,15,18-triol can be isolated from the CHCl₃ extract of the cones of Larix koempferi .

HY-N1659

2,3-Dihydropodocarpusflavone A	Flavonoids other families Classification of Application Fields Source classification Pteridaceae Other Diseases Phenols Polyphenols Plants Biflavones Disease Research Fields	Others
2,3-Dihydropodocarpusflavone A is a biflavonoid, which can be isolated from Cycas beddomei .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli Cell-free (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P702398

	OPN1LW Protein, Human (Cell-Free, His) Long-wave-sensitive opsin 1; Red cone photoreceptor pigment; Red-sensitive opsin; ROP	Human	E. coli Cell-free
	OPN1LW protein, crucial for vision, is a vital element of visual pigments responsible for light absorption. The pigments consist of opsin, forming a covalent bond with cis-retinal. This molecular mechanism is indispensable for perceiving light stimuli in vision. OPN1LW Protein, Human (Cell-Free, His) is the recombinant human-derived OPN1LW protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPN1LW Protein, Human (Cell-Free, His) is 364 a.a., with molecular weight of 43.4 kDa.

HY-P702399

	OPN1MW Protein, Human (Cell-Free, His) Medium-wave-sensitive opsin 1; Green cone photoreceptor pigment; Green-sensitive opsin; GOP	Human	E. coli Cell-free
	OPN1MW protein, vital for vision, plays a crucial role in visual pigments, absorbing light and facilitating vision. These pigments consist of opsin, forming a covalent bond with cis-retinal. The OPN1MW protein, along with cis-retinal, contributes to the intricate molecular mechanism essential for perceiving light stimuli, enabling the visual process. OPN1MW Protein, Human (Cell-Free, His) is the recombinant human-derived OPN1MW protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of OPN1MW Protein, Human (Cell-Free, His) is 364 a.a., with molecular weight of 46.6 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81439

CRX Antibody (YA1184)

cone rod homeobox; CORD 2; CRD; CRX
IHC-P Human

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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cone

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