2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. TCS1105

TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion.

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TCS1105 Chemical Structure

TCS1105 Chemical Structure

CAS No. : 185391-33-7

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Based on 1 publication(s) in Google Scholar

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Description

TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].

Molecular Weight

296.30

Formula

C17H13FN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C(F)C=C1)C(C2=CNC3=C2C=CC=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (421.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3750 mL 16.8748 mL 33.7496 mL
5 mM 0.6750 mL 3.3750 mL 6.7499 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3750 mL 16.8748 mL 33.7496 mL 84.3739 mL
5 mM 0.6750 mL 3.3750 mL 6.7499 mL 16.8748 mL
10 mM 0.3375 mL 1.6875 mL 3.3750 mL 8.4374 mL
15 mM 0.2250 mL 1.1250 mL 2.2500 mL 5.6249 mL
20 mM 0.1687 mL 0.8437 mL 1.6875 mL 4.2187 mL
25 mM 0.1350 mL 0.6750 mL 1.3500 mL 3.3750 mL
30 mM 0.1125 mL 0.5625 mL 1.1250 mL 2.8125 mL
40 mM 0.0844 mL 0.4219 mL 0.8437 mL 2.1093 mL
50 mM 0.0675 mL 0.3375 mL 0.6750 mL 1.6875 mL
60 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4062 mL
80 mM 0.0422 mL 0.2109 mL 0.4219 mL 1.0547 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.8437 mL
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TCS1105 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCS1105185391-33-7TCS 1105TCS-1105GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid Receptoranxiety-like behavioroffensive behaviorsocial dominanceSema3AAGCInhibitorinhibitorinhibit

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