185391-33-7
Chemical Structure
TCS1105
- CAS 番号: 185391-33-7
- Formula:C17H13FN2O2
- Molecular Weight:296.30
IUPAC Name: N-(4-fluorobenzyl)-2-(1H-indol-3-yl)-2-oxoacetamide
InChIKey: VWCCHJFFYCGXFL-UHFFFAOYSA-N
SMILES: O=C(NCC1=CC=C(F)C=C1)C(C2=CNC3=C2C=CC=C3)=O
Biological Activity: TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2].
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TCS1105 | 99.44% | TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion. | ||||||||||||||||||||
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- [1]. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281. [Content Brief]
- [2]. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812. [Content Brief]
Keywords
