Search Result

Results for "

elevation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (7) Calcium Channel (1) Cannabinoid Receptor (1) Carbonic Anhydrase (2) Dipeptidyl Peptidase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (4) Endothelin Receptor (1) Free Fatty Acid Receptor (1) Fungal (3) HDAC (1) Histone Demethylase (1) Histone Methyltransferase (2) Interleukin Related (1) Isotope-Labeled Compounds (4) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) PACAP Receptor (2) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Inflammation/Immunology (11) Metabolic Disease (4) Neurological Disease (3)

By Targets:

Apoptosis (7)

Calcium Channel (1)

Cannabinoid Receptor (1)

Carbonic Anhydrase (2)

Dipeptidyl Peptidase (1)

DNA/RNA Synthesis (1)

Endogenous Metabolite (4)

Endothelin Receptor (1)

Free Fatty Acid Receptor (1)

Fungal (3)

HDAC (1)

Histone Demethylase (1)

Histone Methyltransferase (2)

Interleukin Related (1)

Isotope-Labeled Compounds (4)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (2)

PACAP Receptor (2)

Potassium Channel (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (4)

Toll-like Receptor (TLR) (1)

By Research Areas:

Cancer (11)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (2)

Inflammation/Immunology (11)

Metabolic Disease (4)

Neurological Disease (3)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101906

DC260126 2 Publications Verification	Free Fatty Acid Receptor Apoptosis	Metabolic Disease
DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca ²⁺ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC₅₀: 6.28, 5.96, 7.07, 4.58 μM, respectively) . DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis .

HY-101428

NS-638	Calcium Channel	Neurological Disease
NS-638 is a small nonpeptide molecule with Ca ²⁺-channel blocking properties. K ⁺-stimulated intracellular Ca ²⁺-elevation is blocked with an IC₅₀ value of 3.4 μM.

HY-N7063

Nerol	Reactive Oxygen Species Fungal Mitochondrial Metabolism Apoptosis Endogenous Metabolite	Infection
Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-122099

Riddelline	DNA/RNA Synthesis	Others
Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver .

HY-B1391S

D-Panthenol-d6 Dexpanthenol-d₆	Isotope-Labeled Compounds Endogenous Metabolite	Inflammation/Immunology Cancer
Dexpanthenol-d₆ is deuterium labeled D-Panthenol. D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell.

HY-120295

A-192621	Endothelin Receptor Apoptosis	Cardiovascular Disease Endocrinology
A-192621 is a potent, nonpeptide, orally active and selective endothelin B (ET_B) receptor antagonist with an IC₅₀ of 4.5 nM and a K_i of 8.8 nM. The selectivity of A-192621 is 636-fold higher than ET_A (IC₅₀ of 4280 nM and K_i of 5600 nM). A-192621 promotes apoptosis in PASMCs. A-192621 alos causes elevation of arterial blood pressure and an elevation in the plasma ET-1 level .

HY-B1391

D-Panthenol Dexpanthenol	Endogenous Metabolite	Inflammation/Immunology Cancer
D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell. D-panthenol exhibits nephroprotective effect in AKI, promotes tissue repair and regeneration.

HY-N11887

Linocinnamarin	Reactive Oxygen Species	Inflammation/Immunology
Linocinnamarin is a nature product that could be isolated from Fragaria ananassa Duch. Linocinnamarin has anti-inflammatory activity. Linocinnamarin inhibits antigen-stimulated elevation of intracellular free Ca ²⁺ concentration and reactive oxygen species (ROS) .

HY-B0553

Methazolamide 2 Publications Verification L584601	Carbonic Anhydrase	Inflammation/Immunology Cancer
Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-N6073

Soyasapogenol A	Apoptosis	Inflammation/Immunology
Soyasapogenol A, a triterpene compound, isolated from soybean. Soyasapogenol A directly prevents apoptosis of hepatocytes, and secondly, inhibits the elevation of plasma TNF-α, which consequently results in the prevention of liver damage in the Concanavalin A-induced hepatitis model .

HY-N7063R

Nerol (Standard)	Reactive Oxygen Species Endogenous Metabolite Fungal Mitochondrial Metabolism Apoptosis	Infection
Nerol (Standard) is the analytical standard of Nerol. This product is intended for research and analytical applications. Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-P99645

Goflikicept RPH 104	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Goflikicept (RPH 104) is a hybrid protein that selectively binds and inactivates both circulating IL-1ß and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI) .

HY-114826

Prostaglandin E2-1-glyceryl ester	Cannabinoid Receptor	Metabolic Disease Cancer
Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB₁ receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca ²⁺ .

HY-N7364S

(E)-β-Farnesene-d6 trans-β-Farnesene-d₆	Fungal Isotope-Labeled Compounds	Cancer
(E)-β-Farnesene-d₆ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-N7436S

Methyl propyl disulfide-d3	Others Isotope-Labeled Compounds	Cancer
Methyl propyl disulfide-d₃ is deuterated labeled Nerol (HY-N7063). Nerol is a constituent of neroli oil. Nerol Nerol triggers mitochondrial dysfunction and induces apoptosis via elevation of Ca ²⁺ and ROS. Antifungal activity .

HY-103433

K579	Dipeptidyl Peptidase	Metabolic Disease
K579 is a potent and orally active dipeptidyl peptidase IV inhibitor. K579 inhibits the blood glucose elevation. K579 increases the plasma insulin and active forms of glucagon-like peptide-1 (GLP-1). K579 has the potential for the research of diabetic .

HY-W027126

Hepatoprotective agent-2	Apoptosis	Metabolic Disease
Hepatoprotective agent-2 (compound 2a), a 4-phenyl-tetrahydroquinoline derivative, displays a remarkable hepatoprotective effect. Hepatoprotective agent-2 has antiapoptotic activity. Hepatoprotective agent-2 notably prevents the chemically induced elevation of hepatic indicators associated with liver injury .

HY-B0553S

Methazolamide-d6 L584601-d₆	Isotope-Labeled Compounds Carbonic Anhydrase	Inflammation/Immunology
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a Ki of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders[1][2].

HY-129421

PA-9	PACAP Receptor	Neurological Disease Inflammation/Immunology
PA-9 is a pituitary adenylate cyclase-activating polypeptide (PACAP) type I (PAC1) receptor antagonist. PA-9 dose dependently inhibits PACAP-induced cAMP elevation with an IC₅₀ of 5.6 nM. PA-9 can be used for the research of neuropathic and/or inflammatory pain .

HY-N4237

Saikogenin D	Prostaglandin Receptor Potassium Channel	Inflammation/Immunology
Saikogenin D is isolated from Bupleurum chinense, has anti-inflammatory effects. Saikogenin D activates epoxygenases that converts arachidonic acid to epoxyeicosanoids and dihydroxyeicosatrienoic acids, and the metabolites secondarily inhibit prostaglandin E2 (PGE2) production. Saikogenin D results in an elevation of [Ca ²⁺]i due to Ca ²⁺ release from intracellular stores .

HY-133529

PA-8	PACAP Receptor	Neurological Disease Inflammation/Immunology
PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC₅₀ of 2 nM .

HY-120400

KDM5-C70 3 Publications Verification	Histone Demethylase	Cancer
KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels .

HY-110353

CU-T12-9 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS .

HY-N1940

β-Anhydroicaritin 1 Publications Verification
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-144094

EZH2-IN-9	Histone Methyltransferase	Cancer
EZH2-IN-9 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-9 has the potential for the research of cancer diseases (extracted from patent WO2021180235A1, compound 17) .

HY-143616

EZH2-IN-7	Histone Methyltransferase	Cancer
EZH2-IN-7 is a potent inhibitor of EZH2. EZH2 overexpression or mutations in the SET region (Y641F, Y641N, A687V, A677G point mutations) all lead to abnormal elevation of H3K27me3 and promote the growth and development of many types of tumors, such as breast cancer, prostate cancer, leukemia, etc. EZH2-IN-7 has the potential for the research of cancer diseases (extracted from patent WO2021129629A1, compound 259) .

HY-162319

Tubulin/HDAC-IN-4	Apoptosis HDAC Microtubule/Tubulin Reactive Oxygen Species	Cancer
Tubulin/HDAC-IN-4 (compound 9n) is a dual Tubulin and HDAC inhibitor with IC₅₀ values of 0.73, 0.43, 0.62, 2.34 µM for HDAC1, HDAC2, HDAC6, HDAC7, respectively. Tubulin/HDAC-IN-4 inhibits the tubulin polymerization by targeting the colchicine binding site. Tubulin/HDAC-IN-4 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin/HDAC-IN-4 induces a significant elevation of intracellular ROS levels. Tubulin/HDAC-IN-4 shows anti-angiogenesis activity and anticancer activity .

Goflikicept RPH 104	Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Goflikicept (RPH 104) is a hybrid protein that selectively binds and inactivates both circulating IL-1ß and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI) .

Cat. No.	Product Name	Category	Target	Chemical Structure