1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. NS-638

NS-638 

Cat. No.: HY-101428 Purity: ≥98.0%
Handling Instructions

NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM.

For research use only. We do not sell to patients.

NS-638 Chemical Structure

NS-638 Chemical Structure

CAS No. : 150493-34-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 90 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 90 In-stock
Estimated Time of Arrival: December 31
Solid
2 mg USD 50 In-stock
Estimated Time of Arrival: December 31
5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 150 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 470 In-stock
Estimated Time of Arrival: December 31
100 mg USD 640 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM.

IC50 & Target

IC50: 3.4 μM (K+-stimulated intracellular Ca2+-elevation) [1]

In Vitro

NS-638 dose dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 μM, respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked with an IC50 value of 3.4 μM. At this concentration no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

325.72

Formula

C₁₅H₁₁ClF₃N₃

CAS No.
SMILES

NC1=NC2=CC(C(F)(F)F)=CC=C2N1CC3=CC=C(Cl)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (104.38 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0701 mL 15.3506 mL 30.7012 mL
5 mM 0.6140 mL 3.0701 mL 6.1402 mL
10 mM 0.3070 mL 1.5351 mL 3.0701 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[1]

Mice: In the mouse middle cerebral artery occlusion model, NS-638 is administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

NS-638NS638NS 638Calcium ChannelCa2+ channelsCa channelsInhibitorinhibitorinhibit

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NS-638
Cat. No.:
HY-101428
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