Prostaglandin E2-1-glyceryl ester
Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
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- CAS. Nr.: 37497-47-5
- Formel: C23H38O7
- Molecular Weight:426.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
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HY-10863
AnandamideCB1/2 Agonist -
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Prostaglandin F2α-1-glyceryl esterEndogenous Metabolite -
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S-1 MethanandamideCB1 Receptor Ligand -
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SKM 4-45-1AEA Fluorescent Substrate -
HY-111293
ArachidonamideFAAH Substrate -
HY-116380
CB2 receptor antagonist 5CB2 Ligand -
HY-130357
15(S)-HETE EthanolamideCannabinoid Analog -
HY-139230
OLHHACB1 Antagonist/PPARα Agonist -
HY-120467
Bima SAProstaglandin Analog -
HY-137483
Prostaglandin D2 serinol amideEndogenous Hormone -
HY-116250
Prostaglandin D2-1-glyceryl esterEndogenous Hormone -
HY-118556
Prostaglandin E2 serinol amideEndogenous Hormone
Biologische Aktivität
Beschreibung
IC50 & Target
EC50: 150 nM (Ca2+ in NG108-15 cells)[2].
In Vitro
Prostaglandin E2-1-glyceryl ester is rapidly hydrolyzed in rat plasma to generate PGE2 (t1⁄2 = 14 s) but is only slowly metabolized in human plasma (t1⁄2 = 10 min)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 37497-47-5
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Molecular Weight 426.54
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Formel C23H38O7
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SMILES
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(OCC(O)CO)=O
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Synonyms
PGE2-1-glyceyl ester
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. K R Kozak, et al. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. J Biol Chem. 2001 Oct 5;276(40):36993-8. [Content Brief]
[2]. T Sugiura, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996 Dec 4;229(1):58-64. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Prostaglandin E2-1-glyceryl ester Related Classifications
HY-114826 Related Classifications
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