Prostaglandin E2-1-glyceryl ester
Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+.
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- CAS No.: 37497-47-5
- 화학식: C23H38O7
- 분자량:426.54
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
EC50: 150 nM (Ca2+ in NG108-15 cells)[2].
In Vitro
Prostaglandin E2-1-glyceryl ester is rapidly hydrolyzed in rat plasma to generate PGE2 (t1⁄2 = 14 s) but is only slowly metabolized in human plasma (t1⁄2 = 10 min)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 37497-47-5
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분자량 426.54
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화학식 C23H38O7
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SMILES
CCCCC[C@H](O)/C=C/[C@@H]1[C@H](C(C[C@H]1O)=O)C/C=C\CCCC(OCC(O)CO)=O
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Synonyms
PGE2-1-glyceyl ester
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. K R Kozak, et al. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. J Biol Chem. 2001 Oct 5;276(40):36993-8. [Content Brief]
[2]. T Sugiura, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996 Dec 4;229(1):58-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Prostaglandin E2-1-glyceryl ester Related Classifications
HY-114826 Related Classifications
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