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in vivo half-life

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54

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30

Biochemical Assay Reagents

1

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2

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2

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27

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P990735
    Donzakimig

    		Interleukin Related Inflammation/Immunology
    Donzakimig is a trispecific anti-IL-13/IL-22/HSA antibody. Donzakimig adopts a Fab-scFv-scFv structural format (without an Fc region), in which the Fab domain is linked to the scFv domains via a S (G4S)2 linker. Donzakimig binds to and inhibits the activities of IL-13 and IL-22, thereby blocking the signal transduction of these two cytokines. Donzakimig can extend its serum half-life by binding to human serum albumin, enhancing its in vivo stability and achieving long-acting efficacy. Donzakimig can be used in research on moderate-to-severe atopic dermatitis, moderate-to-severe asthma (especially eosinophilic type), psoriasis, inflammatory bowel disease, and other conditions .
    Donzakimig
  • HY-168046
    ALG-055009

    		Thyroid Hormone Receptor Metabolic Disease
    ALG-055009 is a selective and orally active Thyroid Hormone Receptor Beta (THR-β) agonist with an EC50 of 0.063 μM. ALG-055009 binds to the T3 hormone pocket of human THR-β, forming polar interactions with protein residues. ALG-055009 can lower total cholesterol levels in rats on a high-fat diet. ALG-055009 exhibits high metabolic stability, good permeability, a long in vivo half-life, and limited drug-drug interaction liability. ALG-055009 can be used in studies related to metabolic dysfunction-associated fatty liver disease .
    ALG-055009
  • HY-152142
    DN-1289
    1 Publications Verification

    		 JNK Neurological Disease
    DN-1289 is an orally active and selective inhibitor of dual leucine zipper kinase (DLK; IC50=17 nM) and leucine zipper-bearing kinase (LZK; IC50=40 nM). DN-1289 results significant attenuation of optic nerve crush (ONC)-induced p-c-Jun in mice model. DN-1289 has excellent in vivo plasma half-life and blood-brain barrier permeability .
    DN-1289
  • HY-W440702
    Cholesterol-PEG2000-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG2000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-NHS can be used in drug delivery research .
    Cholesterol-PEG2000-NHS
  • HY-158991
    I1421

    		CFTR Inflammation/Immunology
    I1421 is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) with an EC50 of 64 nM for WT CFTR currents. I1421 also allosterically activates multiple mutants causing cystic fibrosis (CF) with good in vivo potency, with an oral bioavailability of 60% in mice corresponding to a half-life of 75 min. I1421 synergizes with Elexacaftor (HY-111772) to enhance CFTR currents .
    I1421
  • HY-W440697
    Cholesterol-PEG1000-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-NHS can be used in drug delivery research .
    Cholesterol-PEG1000-NHS
  • HY-124713
    ML372

    		DNA/RNA Synthesis Neurological Disease
    ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo .
    ML372
  • HY-120374
    V-PYRRO/NO

    		Biochemical Assay Reagents Metabolic Disease
    V-PYRRO/NO is a NO donor in vivo. Following hepatic metabolism, it spontaneously decomposes with a half-life of 3 seconds to liberate NO.
    V-PYRRO/NO
  • HY-W440704
    Cholesterol-PEG5000-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-NHS can be used in drug delivery research .
    Cholesterol-PEG5000-NHS
  • HY-W440718
    Cholesterol-PEG1000-Mal

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Mal can be used in drug delivery research .
    Cholesterol-PEG1000-Mal
  • HY-33914
    4-Hydroxymethylpyrazole

    		Drug Metabolite Metabolic Disease
    4-Hydroxymethylpyrazole is the primary metabolite of Fomepizole (HY-B0876) produced through hepatic oxidative metabolism. 4-Hydroxymethylpyrazole exhibits a plasma concentration that is positively correlated with the administered dosage of Fomepizole, and it demonstrates a relatively short half-life. 4-Hydroxymethylpyrazole demonstrates inhibitory effects on alcohol dehydrogenase (ADH) in both humans and monkeys, but its inhibition constant is significantly higher than that of Fomepizole, rendering its in vivo impact negligible .
    4-Hydroxymethylpyrazole
  • HY-P3347
    NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)

    		Apelin Receptor (APJ) Cardiovascular Disease
    NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life .
    NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)
  • HY-15616
    BMS-470539

    		Melanocortin Receptor Cancer
    BMS-470539 is a synthetic MC-1R agonist with potent anti-inflammatory properties. BMS-470539 selectively activates human and murine MC-1R with EC50 values ??of 16.8 nM and 11.6 nM, respectively. In vitro studies have shown that BMS-470539 is able to dose-dependently inhibit TNF-alpha-induced NF-kB activation in human melanoma cells expressing MC-1R. In vivo, subcutaneous injection of BMS-470539 into BALB/c mice effectively inhibited LPS-induced TNF-alpha production with an ED50 of approximately 10 μmol/kg and a pharmacodynamic half-life of approximately 8 hours. It also significantly reduced leukocyte infiltration in a lung inflammation model and attenuated paw swelling in a delayed-type hypersensitivity model, highlighting its efficacy as an anti-inflammatory agent through MC-1R modulation .
    BMS-470539
  • HY-10758
    FXa-IN-1

    		Factor Xa Cardiovascular Disease
    FXa-IN-1 is a FXa inhibitor (IC50: 3 nM, Ki: 0.7 nM) with respectable oral bioavailability and half-life in vivo. FXa-IN-1 can be used for thromboembolic disorders .
    FXa-IN-1
  • HY-137270
    16,16-Dimethyl PGA2

    16,16-Dimethyl prostaglandin A2; Di-M-PGA2

    		 Endogenous Metabolite Cardiovascular Disease Endocrinology Cancer
    16,16-Dimethyl PGA2 is an orally active prostaglandin analog with a prolonged in vivo half-life. 16,16-Dimethyl PGA2 can be used to study hypertension .
    16,16-Dimethyl PGA2
  • HY-176052
    PPO-allene

    		Bacterial Neurological Disease
    PPO-allene is a covalent botulinum neurotoxin (BoNT) light chain inhibitor (IC50: 20.9 μM). PPO-allene (0.3 mg/kg, i.v.) demonstrates an in vivo half-life of approximately 1.5 h in mice .
    PPO-allene
  • HY-W591891
    Cholesterol-PEG1000-acid

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-acid can be used in drug delivery research .
    Cholesterol-PEG1000-acid
  • HY-163505
    Anti-MRSA agent 11

    		Bacterial Others
    Anti-MRSA agent 11 suppresses fluoroquinolone-sensitive strain USA500 and -resistant MRSA isolate Mu50 (MIC =0.39 μg/mL). Anti-MRSA agent 11 displayes favorable in vivo half-life and safety profiles .
    Anti-MRSA agent 11
  • HY-W440695
    Cholesterol-PEG3400-azide

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-azide can be used in drug delivery research .
    Cholesterol-PEG3400-azide
  • HY-W440692
    Cholesterol-PEG5000-amine

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-amine can be used in drug delivery research .
    Cholesterol-PEG5000-amine
  • HY-W440696
    Cholesterol-PEG5000-azide

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-azide can be used in drug delivery research .
    Cholesterol-PEG5000-azide
  • HY-W591912
    Cholesterol-PEG1000-methoxy

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-methoxy is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-methoxy can be used in drug delivery research .
    Cholesterol-PEG1000-methoxy
  • HY-W440723
    Cholesterol-PEG2000-Thiol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG2000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG2000-Thiol can be used in drug delivery research .
    Cholesterol-PEG2000-Thiol
  • HY-W440707
    Cholesterol-PEG3400-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-alcohol can be used in drug delivery research .
    Cholesterol-PEG3400-alcohol
  • HY-W440721
    Cholesterol-PEG5000-Mal

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Mal can be used in drug delivery research .
    Cholesterol-PEG5000-Mal
  • HY-W440693
    Cholesterol-PEG1000-azide

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-azide is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-azide can be used in drug delivery research .
    Cholesterol-PEG1000-azide
  • HY-W440691
    Cholesterol-PEG3400-amine

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-amine is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-amine can be used in drug delivery research .
    Cholesterol-PEG3400-amine
  • HY-W440705
    Cholesterol-PEG1000-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-alcohol can be used in drug delivery research .
    Cholesterol-PEG1000-alcohol
  • HY-W440720
    Cholesterol-PEG3400-Mal

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Mal is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Mal can be used in drug delivery research .
    Cholesterol-PEG3400-Mal
  • HY-W440708
    Cholesterol-PEG5000-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-alcohol can be used in drug delivery research .
    Cholesterol-PEG5000-alcohol
  • HY-W440703
    Cholesterol-PEG3400-NHS

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-NHS is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-NHS can be used in drug delivery research .
    Cholesterol-PEG3400-NHS
  • HY-W440712
    Cholesterol-PEG3400-Biotin

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Biotin can be used in drug delivery research .
    Cholesterol-PEG3400-Biotin
  • HY-156188
    AChE-IN-41

    		Cholinesterase (ChE) Others
    AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo .
    AChE-IN-41
  • HY-162121
    Antitumor agent-129

    		Others Cancer
    Antitumor agent-129 (Compound 68) is a thiazolidin-4-one sulfone derivative and an Osteosarcoma (OS) inhibitor with an IC50 value of 0.217 μM, a half-life of 73.8 min (mouse liver microsome) and an excellent pharmacokinetic profile (in vivo bioavailability F = 115%, intraperitoneal administration). Antitumor agent-129 is a potential candidate for OS research .
    Antitumor agent-129
  • HY-162940
    MerTK/Axl-IN-1

    		TAM Receptor Inflammation/Immunology Cancer
    MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual MerTK/Axl inhibitor, with IC50s of 4.2 and 8.8 nM in Ba/F3, and 0.2 and 0.9 nM in HTRF. MerTK/Axl-IN-1 results in pMerTK inhibition in vivo. MerTK/Axl-IN-1 has long half-life, high oral exposure and bioavailability .
    MerTK/Axl-IN-1
  • HY-P991601
    Anti-IL6 Antibody (MH166)

    		Interleukin Related Inflammation/Immunology
    Anti-IL6 Antibody (MH166) is a murine anti-hIL-6 monoclonal antibody. Anti-IL6 Antibody (MH166) can completely neutralize the activity of hIL-6 in vitro, but when used in combination with hIL-6 in vivo, Anti-IL6 Antibody (MH166) can enhance the activity and prolong the half-life of hIL-6, and increase the production of antigen-specific antibodies .
    Anti-IL6 Antibody (MH166)
  • HY-121814A
    (R)-Acenocoumarol

    (R)-Acenocoumarin; (R)-Nicoumalone

    		 VD/VDR Cardiovascular Disease
    (R)-Acenocoumarol ((R)-Acenocoumarin; (R)-Nicoumalone) is a short-acting and orally active anticoagulant, like Warfarin (HY-B0687), works by inhibiting vitamin K epoxide reductase. (R)-Acenocoumarol has a greater in vivo anticoagulant potency than Warfarin. (R)-Acenocoumarol has a single chiral center that produces two different enantiomeric forms. (R)-Acenocoumarol has a longer plasma elimination half-life (6.6 h) and a slower plasma clearance rate (1.9 L/h) than the (S)-enantiomer, resulting in a stronger in vivo anticoagulant effect.
    (R)-Acenocoumarol
  • HY-W331198
    Tralopyril

    		Insecticide Ferroptosis Infection
    Tralopyril is an orally active, blood-brain barrier-penetrating antifouling insecticide and endocrine disruptor. By interfering with the thyroid hormone system and mitochondrial oxidative phosphorylation, Tralopyril downregulates the transcription of genes such as TRHR, Nkx2.1, TRα and induces ferroptosis. Tralopyril disrupts amino acid, energy and lipid metabolism, exhibits significant skeletal and reproductive toxicity, and causes developmental damage. Tralopyril has a long half-life in vivo and wide tissue distribution, posing potential risks to aquatic organisms and human health. Tralopyril shows species specificity in in vitro liver microsomal metabolism, exerts lethal effects on target insects and laboratory animals, and is commonly used in studies of chlorfenapyr poisoning and related toxic mechanisms .
    Tralopyril
  • HY-168715
    SHP2-IN-33

    		SHP2 Apoptosis MAPKAPK2 (MK2) Cancer
    SHP2-IN-33 (Compound D13) is an allosteric inhibitor of SHP2 with an IC50 of 1.2 μM. In cellular studies, SHP2-IN-33 demonstrates antiproliferative activity with an IC50 of 38 μM against Huh7 cells by arresting the G0/G1 cell cycle, promoting apoptosis (Apoptosis), and suppressing the MAPK signaling pathway. In an in vivo Huh7 xenograft mouse model, SHP2-IN-33 exhibits significant antitumor activity and favorable pharmacokinetics, including 54% oral bioavailability and a half-life of 10.57 hours. SHP2-IN-33 is a promising compound for studying tumor diseases associated with SHP2 .
    SHP2-IN-33
  • HY-W440700
    Cholesterol-PEG5000-acid

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-acid can be used in drug delivery research .
    Cholesterol-PEG5000-acid
  • HY-W440699
    Cholesterol-PEG3400-acid

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-acid is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-acid can be used in drug delivery research .
    Cholesterol-PEG3400-acid
  • HY-W591914
    Cholesterol-PEG5000-methoxy

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-methoxy is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-methoxy can be used in drug delivery research .
    Cholesterol-PEG5000-methoxy
  • HY-W440728
    Cholesterol-PEG3400-Vinylsulfone

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Vinylsulfone can be used in drug delivery research .
    Cholesterol-PEG3400-Vinylsulfone
  • HY-W440717
    Cholesterol-PEG5000-Folate

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Folate is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Folate can be used in drug delivery research .
    Cholesterol-PEG5000-Folate
  • HY-W440716
    Cholesterol-PEG3400-Folate

    		Biochemical Assay Reagents Others
    Cholesterol-PEG3400-Folate is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG3400-Folate can be used in drug delivery research .
    Cholesterol-PEG3400-Folate
  • HY-W440726
    Cholesterol-PEG1000-Vinylsulfone

    		Biochemical Assay Reagents Others
    Cholesterol-PEG1000-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG1000-Vinylsulfone can be used in drug delivery research .
    Cholesterol-PEG1000-Vinylsulfone
  • HY-W440725
    Cholesterol-PEG5000-Thiol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Thiol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Thiol can be used in drug delivery research .
    Cholesterol-PEG5000-Thiol
  • HY-W440713
    Cholesterol-PEG5000-Biotin

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Biotin is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Biotin can be used in drug delivery research .
    Cholesterol-PEG5000-Biotin
  • HY-W440709
    Cholesterol-PEG10000-alcohol

    		Biochemical Assay Reagents Others
    Cholesterol-PEG10000-alcohol is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG10000-alcohol can be used in drug delivery research .
    Cholesterol-PEG10000-alcohol
  • HY-W440729
    Cholesterol-PEG5000-Vinylsulfone

    		Biochemical Assay Reagents Others
    Cholesterol-PEG5000-Vinylsulfone is a cholesterol PEG derivative that can form micelles through molecular self-assembly and has a longer half-life in vivo. Cholesterol-PEG5000-Vinylsulfone can be used in drug delivery research .
    Cholesterol-PEG5000-Vinylsulfone

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