Antitumor agent-129

Cat. No.: HY-162121: Data Sheet Handling Instructions
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Antitumor agent-129 (Compound 68) is a thiazolidin-4-one sulfone derivative and an Osteosarcoma (OS) inhibitor with an IC₅₀ value of 0.217 μM, a half-life of 73.8 min (mouse liver microsome) and an excellent pharmacokinetic profile (in vivo bioavailability F = 115%, intraperitoneal administration). Antitumor agent-129 is a potential candidate for OS research.

For research use only. We do not sell to patients.

Antitumor agent-129 Chemical Structure

CAS No. : 3030289-45-0

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Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
143B	IC₅₀	0.295 μM Compound: 68	Antiproliferative activity against human 143B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human 143B cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
A549	IC₅₀	1.891 μM Compound: 68	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
HOS-TE85	IC₅₀	0.217 μM Compound: 68	Antiproliferative activity against human MNNG/HOS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MNNG/HOS cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
HOS-TE85	IC₅₀	0.277 μM Compound: 68	Antiproliferative activity against human MNNG/HOS cells transfected with DDX5 shRNA assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MNNG/HOS cells transfected with DDX5 shRNA assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
MG-63	IC₅₀	1.092 μM Compound: 68	Antiproliferative activity against human MG-63 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MG-63 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
MGC-803	IC₅₀	0.394 μM Compound: 68	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
PC-3	IC₅₀	4.3 μM Compound: 68	Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human PC-3 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
SAOS-2	IC₅₀	0.43 μM Compound: 68	Antiproliferative activity against human SAOS-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human SAOS-2 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]
SJSA-1	IC₅₀	0.304 μM Compound: 68	Antiproliferative activity against human SJSA-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay Antiproliferative activity against human SJSA-1 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK8 assay	[PMID: 38232462]

Molecular Weight

448.49

Formula

C₂₀H₂₄N₄O₆S

CAS No.

3030289-45-0

SMILES

O=C(NCCCCOC)C1=NC(C2N(C3=NC=CC=C3OC)C(CS2(=O)=O)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xuwen Chen, et al. Discovery of potent thiazolidin-4-one sulfone derivatives for inhibition of proliferation of osteosarcoma in vitro and in vivo, European Journal of Medicinal Chemistry, 2024, 116082, ISSN 0223-5234.