3030289-45-0
3030289-45-0
Chemical Structure
Antitumor agent-129
- CAS No.: 3030289-45-0
- Formula:C20H24N4O6S
- Molecular Weight:448.49
InChIKey: QLEVZKHTLFQHEO-UHFFFAOYSA-N
SMILES: O=C(NCCCCOC)C1=NC(C2N(C3=NC=CC=C3OC)C(CS2(=O)=O)=O)=CC=C1
Biological Activity: Antitumor agent-129 (Compound 68) is a thiazolidin-4-one sulfone derivative and an Osteosarcoma (OS) inhibitor with an IC50 value of 0.217 μM, a half-life of 73.8 min (mouse liver microsome) and an excellent pharmacokinetic profile (in vivo bioavailability F = 115%, intraperitoneal administration). Antitumor agent-129 is a potential candidate for OS research[1].
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Antitumor agent-129 | Antitumor agent-129 (Compound 68) is a thiazolidin-4-one sulfone derivative and an Osteosarcoma (OS) inhibitor with an IC50 value of 0.217 μM, a half-life of 73.8 min (mouse liver microsome) and an excellent pharmacokinetic profile (in vivo bioavailability F = 115%, intraperitoneal administration). Antitumor agent-129 is a potential candidate for OS research. | |||||||||||||||||||||
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References
Keywords
