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  3. ML372

ML372 

Cat. No.: HY-124713 Purity: 99.43%
Handling Instructions

ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo.

For research use only. We do not sell to patients.

ML372 Chemical Structure

ML372 Chemical Structure

CAS No. : 1331745-61-9

Size Price Stock Quantity
5 mg USD 390 In-stock
Estimated Time of Arrival: December 31
10 mg USD 620 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1950 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2980 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].

Molecular Weight

360.43

Formula

C18H20N2O4S

CAS No.
SMILES

O=C(C1CCN(C2=NC=C(C3=CC=C(OCCCO4)C4=C3)S2)CC1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (92.47 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7745 mL 13.8723 mL 27.7446 mL
5 mM 0.5549 mL 2.7745 mL 5.5489 mL
10 mM 0.2774 mL 1.3872 mL 2.7745 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.94 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
ML372
Cat. No.:
HY-124713
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