1331745-61-9
1331745-61-9
Chemical Structure
ML372
- CAS No.: 1331745-61-9
- Formula:C18H20N2O4S
- Molecular Weight:360.43
IUPAC Name: 1-(5-(3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)thiazol-2-yl)piperidine-4-carboxylic acid
InChIKey: HAVNRFQWAXTDTI-UHFFFAOYSA-N
SMILES: O=C(C1CCN(C2=NC=C(C3=CC=C(OCCCO4)C4=C3)S2)CC1)O
Biological Activity: ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ML372 | 99.17% | ML372 inhibits survival motor neuron (SMN) protein ubiquitination, increases SMN protein stability without affecting mRNA expression. ML372 improves spinal muscular atrophy (SMA) in mice. ML372 is brain penetrant and has a reasonable exposure and half-life in vivo. | ||||||||||||||||||||
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References
Keywords
