Anti-MRSA agent 11
Anti-MRSA agent 11 suppresses fluoroquinolone-sensitive strain USA500 and -resistant MRSA isolate Mu50 (MIC =0.39 μg/mL). Anti-MRSA agent 11 displayes favorable in vivo half-life and safety profiles.
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- CAS. Nr.: 3029704-83-1
- Formel: C24H18F2N4O3
- Molecular Weight:448.42
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Biologische Aktivität
Beschreibung
In Vitro
Anti-MRSA agent 11 (100 μM; 24 h) is devoid of cytotoxicity in both A549 and HEK-293 cells. Anti-MRSA agent 11 highly selectives toxicity toward bacterial cells[1].
Anti-MRSA agent 11 (0.25 μg/ml; 15 generation) has long-lasting antibacterial activity for MRSA strain ATCC33591[1].
Anti-MRSA agent 11 can pass through the cell membrane of bacteria, especially the outer membrane of Gram-negative bacteria, and enter the interior of bacteria to play a role[1].
Anti-MRSA agent 11 inhibits topoisomerase IV of bacteria, thereby interfering with the process of genetic material transfer of bacteria[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Pharmacokinetic Analysis in male SD rats[1]
| Route | Dose (mg/kg) | AUCt (ng•h/mL) | AUC0_INF (ng•h/mL) | T1/2 (h) | Tmax (h) | Cmax (ng/mL) | C0 (ng/mL) | Cl (L•h/kg) | MRT0_t (h) | MRT0_INF (h) | F (%) |
| i.v. | 10 | 9060 | 9100 | 4.23 | / | / | 11800 | 18.5 | 1.01 | 1.20 | 0.9 |
| p.o. | 20 | 162 | 171 | 2.16 | 2.67 | 31.0 | / | / | 3.51 | 4.20 | / |