2. Anti-infection Cell Cycle/DNA Damage
  3. HSV DNA/RNA Synthesis
  4. (Rac)-Adibelivir

(Rac)-Adibelivir ((Rac)-IM-250) is a blood-brain barrier-penetrant HSV helicase-primase inhibitor and metabolic stabilizer with antiviral activity. (Rac)-Adibelivir is also effective against Acyclovir (HY-17422)-resistant strains, and its deuterated structure exhibits enhanced metabolic stability, reducing the formation of hydroxylated metabolites. (Rac)-Adibelivir prolongs in vivo half-life, reduces administration dosage, improves oral bioavailability, and achieves higher brain exposure in mice. (Rac)-Adibelivir can be used in the research of herpes simplex infection, herpes encephalitis and Alzheimer's disease.

For research use only. We do not sell to patients.

(Rac)-Adibelivir

(Rac)-Adibelivir Chemical Structure

CAS No. : 2137928-83-5

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(Rac)-Adibelivir Related Antibodies

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Description

(Rac)-Adibelivir ((Rac)-IM-250) is a blood-brain barrier-penetrant HSV helicase-primase inhibitor and metabolic stabilizer with antiviral activity. (Rac)-Adibelivir is also effective against Acyclovir (HY-17422)-resistant strains, and its deuterated structure exhibits enhanced metabolic stability, reducing the formation of hydroxylated metabolites. (Rac)-Adibelivir prolongs in vivo half-life, reduces administration dosage, improves oral bioavailability, and achieves higher brain exposure in mice. (Rac)-Adibelivir can be used in the research of herpes simplex infection, herpes encephalitis and Alzheimer's disease[1].

IC50 & Target

Helicase

 

In Vitro

(Rac)-Adibelivir (Example 7) inhibits wild-type HSV-1, HSV-2, and ACV-resistant HSV-1 replication in Vero cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-Adibelivir Related Antibodies

Cell Viability Assay[1]

Cell Line: Vero cells
Concentration: IC50
Incubation Time: /
Result: Inhibited wild-type HSV-1, HSV-2, and ACV-resistant HSV-1 replication in Vero cells with IC50 values of 25-100 nM, 25-100 nM, and 25-100 nM, respectively.
In Vivo

(Rac)-Adibelivir (Example C7) (2-10 mg/kg; p.o., i.v.; single dose) enantiomer Example 4/2 shows oral bioavailability of 201% and systemic clearance of 188 mL/(h*kg) in male C57Bl/6N mice[1].
(Rac)-Adibelivir (10 mg/kg; p.o.; single dose) enantiomer Example 4/2 achieves a brain-to-plasma ratio of 1.57 in mice after oral administration, with improved plasma and brain exposure relative to its non-deuterated matched pair[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6N Mice (male, 21-25 g)[1]
Dosage: 10 mg/kg (oral); 2 mg/kg (intravenous)
Administration: p.o.; single dose; i.v.; single dose
Result: Reached mean Cmax of 4607 ng/mL, mean AUC(0-tz) of 80231 ng*h/mL, and mean bioavailability of 201% after oral administration.
Reached mean C0 of 16.2 ng/mL, mean AUC(0-tz) of 7997 ng*h/mL, mean AUC(0-inf) of 10648 ng*h/mL, mean elimination half-life (t1/2z) of 11.3 h, mean clearance (CL) of 188 mL/(h*kg), and mean volume of distribution (Vz) of 3074 mL/kg after intravenous administration.
Animal Model: C57Bl/6N Mice (21-26 g)[1]
Dosage: 10 mg/kg
Administration: p.o.; single dose
Result: Achieved mean plasma concentration of 5474 ng/mL, mean brain concentration of 8609 ng/mL, and brain-to-plasma ratio of 1.57 at 4 hours post-dose.
Molecular Weight

435.51

Formula

C20H19F2N3O2S2
CAS No.
Appearance

Powder

SMILES

FC(C=CC(F)=C1)=C1C(C=C2)=CC=C2CC(N(C3=NC(C)=C(S(C)(=N)=O)S3)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(Rac)-Adibelivir Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Adibelivir2137928-83-5(Rac)-IM-250HSVDNA/RNA SynthesisHerpes simplex virusherpes simplex infectionsherpesviral helicase primasehydroxylated metaboliteherpes encephalitisHSV-1miceHSV-2herpes simplex virusesAlzheimer diseaseacyclovir-resistant strainsInhibitorinhibitorinhibit

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