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lxr+agonist

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By Targets:	Apoptosis (2) Bacterial (1) Endogenous Metabolite (1) FXR (2) iGluR (1) LXR (19) PPAR (2) Reference Standards (3) ROR (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (10) Endocrinology (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (10) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10627A

GW3965 hydrochloride 25+ Cited Publications	LXR	Cardiovascular Disease Cancer
GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .

HY-10626

T0901317 Maximum Cited Publications 44 Publications Verification	LXR FXR ROR Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
T0901317 is an orally active and highly selective *LXR* agonist with an EC₅₀ of 20 nM for LXRα . T0901317 activates FXR with an EC₅₀ of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with K_i values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .

HY-10627

GW3965 25+ Cited Publications	LXR	Cardiovascular Disease
GW3965 is a potent, selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .

HY-16940

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol	LXR iGluR Endogenous Metabolite	Metabolic Disease
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous *LXR* agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

HY-129098

DMHCA 1 Publications Verification	LXR	Metabolic Disease
DMHCA, a potent and selective *LXR* agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects?and can be used for the research of cholesterol homeostasis diabetes .

HY-111498A

RGX-104 3 Publications Verification Abequolixron	LXR	Inflammation/Immunology Cancer
RGX-104 is an orally bioavailable and potent liver-X nuclear hormone receptor *(LXR)* agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-111498

RGX-104 hydrochloride 3 Publications Verification Abequolixron hydrochloride	LXR	Inflammation/Immunology Cancer
RGX-104 hydrochloride is a small-molecule *LXR* agonist that modulates innate immunity via transcriptional activation of the ApoE gene.

HY-144549

LXR agonist 1	LXR	Cardiovascular Disease
LXR (Liver X receptor) agonist 1 is potent *LXR* agonist with AC₅₀s of 1.5 nM and 12 nM for LXR-α and LXR-β, respectively. LXR agonist 1 has the potential for the research of atherosclerosis .

HY-N15574

Saringosterol	LXR Bacterial PPAR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a *LXR* agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities .

HY-116969

22(R)-Hydroxycholesterol Narthesterol	LXR	Metabolic Disease
22(R)-Hydroxycholesterol (Narthesterol) is an endogenous *LXR* agonist. 22(R)-Hydroxycholesterol (Narthesterol) can be used for tangier disease research .

HY-125772

Acetyl podocarpic acid anhydride Acetylpodocarpic dimer; APD	LXR	Cardiovascular Disease
Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor(LXR) agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and research of atherosclerosis, especially in the context of low HDL levels .

HY-179278

LXR agonist 4	LXR	Cardiovascular Disease Metabolic Disease Endocrinology
LXR agonist 4 is a selective LXR inverse agonist with IC₅₀ values of 7.6 (LXRα) and 2.9 μM (LXRβ), respectively. LXR agonist 4 exhibits selectivity over RORα and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD) .

HY-146288

LXR agonist 2	LXR	Metabolic Disease
LXR agonist 2 (compound 18rr) is a potent LXR (liver X receptor) agonist. LXR agonist 2 can stabilize NCOA1 (co-activator), leading to LXR agonism .

HY-154928

GW6340	LXR	Metabolic Disease
GW6340 is an intestinal-specific *LXR* agonist. GW6340 promotes macrophage reverse cholesterol transport (mRCT) .

HY-138007

SR-1903	ROR PPAR LXR	Metabolic Disease Inflammation/Immunology
SR-1903 is an inverse agonist of RORγ and PPARγ (IC₅₀ of ∼100 nM and 209 nM for RORγ and PPARγ, respectively) and a *LXR* agonist. SR-1903 exhibits anti-inflammatory and anti-diabetic efficacy in collagen-induced arthritis and diet-induced obesity mouse models .

HY-N3216

Nagilactone B	LXR	Cardiovascular Disease
Nagilactone B is a liver X receptor (LXR) agonist.

HY-10626R

T0901317 (Standard)	Reference Standards LXR FXR ROR Apoptosis	Cardiovascular Disease Metabolic Disease Cancer
T0901317 (Standard) is the analytical standard of T0901317. This product is intended for research and analytical applications. T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα . T0901317 activates FXR with an EC50 of 5 μM . T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively . T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice .

HY-10627AR

GW3965 hydrochloride (Standard)	Reference Standards LXR	Cardiovascular Disease Cancer
GW3965 (hydrochloride) (Standard) is the analytical standard of GW3965 (hydrochloride). This product is intended for research and analytical applications. GW3965 hydrochloride is a potent and selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .

HY-10627R

GW3965 (Standard)	Reference Standards LXR	Cardiovascular Disease
GW3965 (Standard) is the analytical standard of GW3965 (HY-10627). This product is intended for research and analytical applications. GW3965 is a potent, selective liver X receptor (LXR) agonist with EC₅₀s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively .

24(S)-Hydroxycholesterol 24S-OHC; 24S-HC; Cerebrosterol	Classification of Application Fields Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids Source Classification	LXR iGluR Endogenous Metabolite
24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous *LXR* agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators .

Saringosterol	Structural Classification Marine algae Marine natural products Steroids Source Classification	LXR Bacterial PPAR
Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a *LXR* agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities .

Nagilactone B	Other Terpenoids Cardiovascular Disease Podocarpus nagi Classification of Application Fields Terpenoids Podocarpaceae Plants Disease Research Fields Source Classification	LXR
Nagilactone B is a liver X receptor (LXR) agonist.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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lxr+agonist

Inhibitors & Agonists

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