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Cat. No.: HY-179278

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LXR agonist 4

LXR agonist 4 is a selective LXR inverse agonist with IC₅₀ values of 7.6 (LXRα) and 2.9 μM (LXRβ), respectively. LXR agonist 4 exhibits selectivity over RORα and FXR. LXR agonist 4 robustly suppresses SREBP1c expression without altering ABCA1 or APOE. LXR agonist 4 displays antilipogenic properties and resolves fatty acid-induced steatosis. LXR agonist 4 can be used for the research of atherosclerosis and metabolic dysfunction-associated steatotic liver disease (MASLD).

For research use only. We do not sell to patients.

Formula: C₃₆H₃₁ClF₃NO₂S
Molecular Weight:634.15

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

LXR agonist 4 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

LXRα

7.6 μM (IC₅₀)

LXRβ

2.9 μM (IC₅₀)

In Vitro

LXR agonist 4 (compound 3) (30 μM; 4-24 h) does not inhibit the proliferation of HEK293T or HepG2 cells^[1].
LXR agonist 4 (30 μM; 24 h) suppresses SREBP1c expression without altering ABCA1 or APOE in HepG2 cells^[1].
LXR agonist 4 (30 μM; 72 h) displays antilipogenic properties and resolves fatty acid-induced steatosis in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

HEK293T and HepG2
Concentration:

30 μM
Incubation Time:

4, 14, and 24 h
Result:

Showed no significant inhibition of proliferation in HEK293T and HepG2 cells over 24 hours.

Chemical Information

Molecular Weight 634.15
Formula C₃₆H₃₁ClF₃NO₂S
SMILES

CS(C1=CC=CC(C2=CC=C(C=C2)CN(CC(C3=CC=CC=C3)C4=CC=CC=C4)CC5=CC=CC(C(F)(F)F)=C5Cl)=C1)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bandomir NC, et al. Scaffold Fusion and SAR Transfer with a Chemical Language Model Generates Novel Liver X Receptor Modulators. J Med Chem. 2025;68(21):22588-22598. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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