p56-lck

Isoforms Recommended:	Lck

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Fungal (1) Interleukin Related (1) p38 MAPK (2) PKC (2) Small Interfering RNA (siRNA) (3) Src (7) TNF Receptor (1) γ-secretase (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Neurological Disease (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108485

Damnacanthal	Src Apoptosis Fungal	Infection Inflammation/Immunology Cancer
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 ^lck tyrosine kinase activity. Natural Damnacanthal inhibits *p56 ^lck* autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans* .

HY-112291

SB 220025	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 also inhibits *p56 ^Lck* and PKC with IC₅₀ values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

HY-114980

BMS-279700	Src Interleukin Related TNF Receptor	Inflammation/Immunology
BMS-279700 is an orally active Src-family kinase p56Lck inhibitor. BMS-279700 can block the production of proinflammatory cytokines (IL-2 and TNFα). BMS-279700 can inhibit T cell proliferation. BMS-279700 can be used for the researches of inflammation and immunology .

HY-N12166

2,3,4,6,8-Pentahydroxy-1-methylxanthone	Src	Cardiovascular Disease
2,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to research cardiovascular disease .

HY-112291A

SB 220025 (tri(hydrochloride))	p38 MAPK Src PKC	Inflammation/Immunology
SB 220025 trihydrochloride is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC₅₀ = 60 nM). SB 220025 trihydrochloride also inhibits *p56 ^Lck* and PKC with IC₅₀ values of 3.5 and 2.89 μM, respectively. SB 220025 trihydrochloride inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 trihydrochloride effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .

HY-123650

FSBA hydrochloride 5'-p-Fluorosulfonylbenzoyladenosine	Biochemical Assay Reagents	Cancer
FSBA (5'-p-Fluorosulfonylbenzoyladenosine) hydrochloride is a covalent modifier and affinity labeling reagent for adenine nucleotide-binding proteins. FSBA hydrochloride covalently attaches to the nucleotide-binding sites of pyruvate kinase, glutamate dehydrogenase, and *p56 ^lck, and to a lysine residue in the ATP-binding site of cAMP-dependent protein kinase*, causing loss of enzymatic activity. FSBA hydrochloride can be used for the research of T lymphoma .

HY-120622

BMS-243117	Src	Cancer
BMS-243117 is a potent, and selective benzothiazole based *p56 ^Lck* inhibitor with an IC₅₀ of 4 nM. BMS-243117 inhibits anti-CD3/anti-CD28 induced PBL (human peripheral blood T-cells) proliferation with an IC₅₀ of 1.1 μM. BMS-243117 binds in an extended conformation to the ATP-binding site of Lck .

HY-RS23012

Lck Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lck Rat Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lck Rat Pre-designed siRNA Set A Lck Rat Pre-designed siRNA Set A

HY-RS07550

LCK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LCK Human Pre-designed siRNA Set A contains three designed siRNAs for LCK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LCK Human Pre-designed siRNA Set A LCK Human Pre-designed siRNA Set A

HY-133184

Aminogenistein	Src γ-secretase	Neurological Disease
Aminogenistein is a *p56 ^lck* inhibitor with a 1.2 μM IC₅₀. Aminogenistein inhibits production of Aβ1-40 and Aβ1-42 peptides. Aminogenistein induces accumulation of APP-CTFα and APP-CTFβ, indicating γ-secretase cleavage inhibition. Aminogenistein can be used for the research of alzheimer's disease .

HY-RS16578

Lck Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lck Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lck Mouse Pre-designed siRNA Set A Lck Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108485

Damnacanthal	Infection Quinones Monophenols Classification of Application Fields Anthraquinones Morinda citrifolia Linn. Rubiaceae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Src Apoptosis Fungal
Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia. Damnacanthal is a highly potent, selective inhibitor of p56 ^lck tyrosine kinase activity. Natural Damnacanthal inhibits *p56 ^lck* autophosphorylation and phosphorylation of exogenous substrates with IC₅₀s of 46 nM and 220 nM, respectively. Damnacanthal is a potent inducer of apoptosis with anticancer activity. Damnacanthal also has antinociceptive, anti-inflammatory effects in mice and anti-fungal activity against *Candida albicans* .

HY-N12166

2,3,4,6,8-Pentahydroxy-1-methylxanthone	Cardiovascular Disease Structural Classification Flavonoids Microorganisms Classification of Application Fields Marine natural products Other Flavonoids Marine microorganism Disease Research Fields Source Classification	Src
2,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to research cardiovascular disease .

Species:	Human (2)
Tag:	Tag Free (1) GST (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705567

	Lck Protein, Human (sf9) Tyrosine-protein kinase lck; Leukocyte C-terminal Src kinase (LSK); Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene lck; T cell-specific protein-tyrosine kinase; p56-lck	Human	Sf9 insect cells

HY-P73269

	Lck Protein, Human (Active, sf9, GST) Tyrosine-protein kinase lck; LSK; lck; Hck-3	Human	Sf9 insect cells
	The Lck protein is a non-receptor tyrosine protein kinase that is essential for T cell development and function. Lck is constitutively associated with CD4 and CD8 receptors and is recruited to the TCR/CD3 complex following TCR interaction with MHC. Lck Protein, Human (sf9, GST) is the recombinant human-derived Lck protein, expressed by Sf9 insect cells , with N-GST labeled tag.

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Host:	Mouse (5) Rabbit (2)
Reactivity:	Human (7) Rat (1) Mouse (1)
Application:	IHC-P (2) ICC/IF (2) IF-Tissue (1) IP (2) IHC-F (1) WB (7) FC (1) ELISA (3)
Isotype:	IgG (1) IgG1 (2) IgG/Kappa (1) IgG2a (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (1)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83970

	Lck Antibody (YA3667) YT16; p56lck; pp58lck	WB, ELISA	Human
	Lck Antibody (YA3667) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Lck.

HY-P83970A

	Lck Antibody (YA3667)(PBS only) YT16; p56lck; pp58lck	WB, ELISA	Human
	Lck Antibody (YA3667) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Lck.

HY-P85555

	Lck Antibody (YA5247) lck; lck p56; lck_HUMAN; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell specific protein tyrosine kinase; Lymphocyte cell-specific protein-tyrosine kinase; Lymphocyte Specific Protein Tyrosine Kinase; Membrane associated protein tyrosine kinase; Oncogene lck; p56 lck; p56; LSTRA; protein tyrosine kinase; p56-lck; p56lck; pp58 lck; pp58lck; Protein YT16; Proto oncogene tyrosine protein kinase lck; Proto-oncogene lck; Protooncogene tyrosine protein kinase lck; T cell specific protein tyrosine kinase; T cell-specific protein-tyrosine kinase; T lymphocyte specific protein tyrosine kinase p56lck; Tyrosine-protein kinase lck; YT 16; YT16.	WB	Human
	Lck Antibody (YA5247) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Lck.

HY-P86477

	Lck Antibody (YA6169) lck; Tyrosine-protein kinase lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene lck; T cell-specific protein-tyrosine kinase; p56-lck	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Lck Antibody (YA6169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lck.

HY-P85255

	Lck Antibody (YA4947) lck; Tyrosine-protein kinase lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene lck; T cell-specific protein-tyrosine kinase; p56-lck	WB, IHC-P, IHC-F, ICC/IF, IF-Tissue, IP, FC	Human
	Lck Antibody (YA4947) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Lck.

HY-P80743

	Lck Antibody (YA712) lck; Tyrosine-protein kinase lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene lck; T cell-specific protein-tyrosine kinase; p56-lck	WB	Human
	Lck Antibody (YA712) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lck.

HY-P80743A

	Lck Antibody (YA712)(PBS only) lck; Tyrosine-protein kinase lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene lck; T cell-specific protein-tyrosine kinase; p56-lck	WB	Human
	Lck Antibody (YA712) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lck.

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Products	In-stock - + Add to Cart
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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS23012

Lck Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Lck Rat Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS07550

LCK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
LCK Human Pre-designed siRNA Set A contains three designed siRNAs for LCK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16578

Lck Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Lck Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lck gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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