2,3,4,6,8-Pentahydroxy-1-methylxanthone
2,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to research cardiovascular disease.
For research use only. We do not sell to patients.
- CAS No.: 548740-87-0
- Formula: C14H10O7
- Molecular Weight:290.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
p56 lck[1]
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM with 50 µg/mL ox-LDL, 6h) has protective effect on ox-LDL induced apoptosis in human umbilical vein endothelial cells[2].
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM with 50 µg/mL ox-LDL, 6h) inhibits ox-LDL-induced adhesion molecules expression in human umbilical vein endothelial cells[2].
2,3,4,6,8-Pentahydroxy-1-methylxanthone (1~50µM with 50 µg/mL ox-LDL, 6h) has protective effect on ox-LDL-induced oxidative damage in human umbilical vein endothelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human umbilical vein endothelial cells
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Concentration:1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
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Incubation Time:6h
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Result:The percentage of apoptosis cells significantly decreased to around 20 ~ 40%.
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Cell Line:Human umbilical vein endothelial cells
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Concentration:1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
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Incubation Time:6h
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Result:The level of pro-apoptotic protein Bax decreased significantly, while that of anti-apoptotic protein Bcl-2 increased significantly.
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Cell Line:Human umbilical vein endothelial cells
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Concentration:1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
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Incubation Time:6h
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Result:The protein level of VCAM-1 and ICAM-1 decreased.
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Cell Line:Human umbilical vein endothelial cells
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Concentration:1µM, 5µM, 50µM (with 50 µg/mL ox-LDL)
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Incubation Time:6h
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Result:Activated Nrf2 nuclear translocations and the expression of HO-1 was significantly increased.
Chemical Information
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CAS No. 548740-87-0
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Molecular Weight 290.23
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Formula C14H10O7
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SMILES
O=C1C2=C(OC3=C(C(O)=C(C(C)=C13)O)O)C=C(O)C=C2O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Abdel-Lateff A, et al. Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus. J Nat Prod. 2003 May;66(5):706-8. [Content Brief]
[2]. Hou JR, et al. Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells. Mar Drugs. 2021 Dec 18;19(12):712. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2,3,4,6,8-Pentahydroxy-1-methylxanthone Related Classifications
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