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pH 6.6

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Natural
Products

Targets Recommended:
Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-B1610M
    Sodium Citrate Buffer, 0.5M, pH 6.5

    		Biochemical Assay Reagents Others
    Sodium Citrate Buffer, 0.5M, pH 6.5 is a commonly used buffer composed of citric acid and sodium citrate. Sodium Citrate Buffer, 0.5M, pH 6.5 is widely used in molecular biology, immunohistochemistry (IHC), and biochemistry .
    Sodium Citrate Buffer, 0.5M, pH 6.5
  • HY-N3031
    Grosvenorine

    		Bacterial Apoptosis Bcl-2 Family MDM-2/p53 Glutathione Peroxidase SOD TNF Receptor Interleukin Related Infection Inflammation/Immunology
    Grosvenorine is an orally active flavonoid glycoside found in S. grosvenorii. Grosvenorine exhibits antibacterial, antioxidant and antiinflammation activities. Grosvenorine can induce apoptosis and increases anti-apoptotic Bcl-2 protein expression and reduces pro-apoptotic P53 protein expression in gastric tissues. Grosvenorine enhances mucin/glycoprotein secretion, regulates gastric pH, and reduces gastric lesion incidence.Grosvenorine increases glutathione peroxidase, catalase, and SOD levels, reduces lipid peroxidation (MDA), and lowers TNF-α and IL-6 levels. Grosvenorine can be used for the researches of bacterial infection and Gastric ulcer .
    Grosvenorine
  • HY-105028
    Tenidap

    CP-66248

    		 COX Lipoxygenase Potassium Channel MMP Inflammation/Immunology
    Tenidap (CP-66248) is an orally active dual inhibitor of 5-LOX and COX with anti-inflammatory and immunomodulatory properties. Tenidap downregulates the expression of IL-1 receptors in chondrocytes, reduces the release of pro-inflammatory cytokines such as IL-1, IL-6 and TNF-α, and inhibits MMP production and cartilage degradation. Tenidap also blocks bone resorption and leukocyte adhesion to vascular endothelium, interferes with ion and pH changes associated with mouse sperm capacitation, and selectively enhances the activity of hKir2.3 channels (EC50=1.3 μM). Tenidap is applicable to research related to rheumatoid arthritis .
    Tenidap
  • HY-E70318
    Penicillin G acylase (Immobilized)

    		Endogenous Metabolite Others
    Penicillin G acylase (Immobilized) is an immobilized penicillin acylase with improved temperature and pH stability. Penicillin G acylase (Immobilized) has reusable performance and high recovery rates, retaining much of its original activity after 12 cycles. Among them, Penicillin G acylase (Immobilized) can catalyze penicillin G (PG) to generate 6-aminopenicillanic acid (6-APA) and 7-aminodeacetoxycephalosporanic acid, which are key intermediates for β-lactam antibiotics .
    Penicillin G acylase (Immobilized)
  • HY-148124
    6-epi Doxycycline

    		Drug Isomer Parasite Bacterial MMP Others
    6-Epi-doxycycline is the C-6 epimer of Doxycycline (HY-N0565), formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations .
    6-epi Doxycycline
  • HY-175216
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 is a drug-linker conjugate for ADC. Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala) (HY-175218). Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6 can be used for synthesis of ADCs .
    Maleimide-Ph(3,5-F)-PEG4-Val-Ala-MF-6
  • HY-E70565
    O-Glycoprotease

    		Endonuclease Inflammation/Immunology
    O-Glycoprotease is an O-glycoprotein-specific endoprotease that catalyzes the hydrolysis of peptide bonds directly adjacent to the O-polymer in native mucin-type O-glycosylated proteins. O-Glycoprotease sequence is from Akkermansia muciniphila, recombinantly expressed in E.coli, with a 6×His tag at the C-terminus.
    The enzyme maintains high activity between pH 5.5-7.5 and is resistant to 1M NaCl, but is highly sensitive to EDTA (0.5 mM EDTA) and can be inhibited by Zn 2+.
    O-Glycoprotease
  • HY-N3031R
    Grosvenorine (Standard)

    		Reference Standards Bacterial Apoptosis Bcl-2 Family MDM-2/p53 Glutathione Peroxidase SOD TNF Receptor Interleukin Related Infection Inflammation/Immunology
    Grosvenorine (Standard) is the analytical standard of Grosvenorine. This product is intended for research and analytical applications. Grosvenorine is an orally active flavonoid glycoside found in S. grosvenorii. Grosvenorine exhibits antibacterial, antioxidant and antiinflammation activities. Grosvenorine can induce apoptosis and increases anti-apoptotic Bcl-2 protein expression and reduces pro-apoptotic P53 protein expression in gastric tissues. Grosvenorine enhances mucin/glycoprotein secretion, regulates gastric pH, and reduces gastric lesion incidence.Grosvenorine increases glutathione peroxidase, catalase, and SOD levels, reduces lipid peroxidation (MDA), and lowers TNF-α and IL-6 levels. Grosvenorine can be used for the researches of bacterial infection and Gastric ulcer .
    Grosvenorine (Standard)
  • HY-179197
    Dihydrouracil-Ph-2-Me-piperidine

    		Ligands for E3 Ligase Cancer
    Dihydrouracil-Ph-2-Me-piperidine is an E3 ligase ligand. Dihydrouracil-Ph-2-Me-piperidine can be used to synthesize PROTAC HPK1 Degrader-6 (HY-178459)
    Dihydrouracil-Ph-2-Me-piperidine
  • HY-172728
    Difluorocarboxyfluorescein NHS Ester, 6-isomer

    		Fluorescent Dye Others
    Difluorocarboxyfluorescein NHS Ester, 6-isomer is an amine-reactive fluorinated analog of fluorescein that overcomes some of the key limitations of fluorescein, including greater photostability and a lower pKa (pKa ~ 4.7 versus 6.4 for fluorescein), making its fluorescence essentially pH insensitive in the physiological pH range. Although the mixed isomers of Difluorocarboxyfluorescein NHS Ester, is a preferred, routinely used fluorescent dye for labeling proteins, peptides and nucleotides, purification of peptide and nucleotides labeled with 5(6) isomers might be troublesome due to significant signal broadening in HPLC purification. Peptides and nucleotides labeled with a single isomer usually give better resolution in HPLC purification that is often required in the conjugation processes.
    Difluorocarboxyfluorescein NHS Ester, 6-isomer
  • HY-171946
    TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT is a drug-linker conjugate for ADC. TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT consists of a topoisomerase 1 inhibitor (Topi MF-6) (HY-175203) and a cleavable linker (Maleimide-Ph(3,5-F)-PEG4-Val-Ala) (HY-175218). TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT can be used for synthesis of ADCs .
    TGA-Val-Ala-NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT

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