Search Result

Results for "

pain+relief

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Bacterial (4) Calcium Channel (2) Ceramidase (1) CGRP Receptor (1) COX (2) Dopamine Receptor (1) Drug Derivative (2) Endogenous Metabolite (1) iGluR (1) Isotope-Labeled Compounds (1) Liposome (1) Opioid Receptor (1) Parasite (1) PGE synthase (2) Potassium Channel (1) Reactive Oxygen Species (ROS) (2) Reference Standards (3) Sodium Channel (3) Src (2) STAT (2) Stearoyl-CoA Desaturase (SCD) (2) Toll-like Receptor (TLR) (1) TRP Channel (2) γ-Glutamyl Transferase (GGT) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Infection (4) Inflammation/Immunology (8) Neurological Disease (16)
Oligonucleotides:	Liposome (1)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W105835

Magnesium citrate Trimagnesium dicitrate	Toll-like Receptor (TLR)	Neurological Disease
Magnesium citrate (Trimagnesium dicitrate) is an orally active magnesium-containing compound that can cross the blood-brain barrier (BBB). Magnesium citrate can be used as an intestinal cleanser and is studied for its application in laxatives. Magnesium citrate can also increase the pain threshold and is studied for pain-relief purposes .

HY-120546

Ulixacaltamide 1 Publications Verification Z944; PRAX-944	Calcium Channel	Neurological Disease Inflammation/Immunology
Ulixacaltamide (Z944) is an orally available T-type calcium channel antagonist that can slow the progression of epilepsy. Ulixacaltamide effectively reduces tremor in a normal alkaline tremor animal model. Ulixacaltamide reverses thermal hyperalgesia and mediates pain relief .

HY-N3074

Hexahydrofarnesyl acetone 6,10,14-Trimethyl-2-pentadecanone	Bacterial Antibiotic	Infection Inflammation/Immunology Cancer
Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a oral active sesquiterpene with oral activity, exhibiting antibacterial, anti-inflammatory, and anticancer properties, and is used in pain relief research .

HY-B0683

Limaprost 1 Publications Verification 17α,20-dimethyl-δ2-PGE1; ONO1206; OP1206	PGE synthase	Cardiovascular Disease Inflammation/Immunology
Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research .

HY-N0701

(-)-Asarinin 1 Publications Verification	Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
(-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects .

HY-145339

ARN19702	Ceramidase	Neurological Disease Inflammation/Immunology
ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC₅₀ of 230 nM for human NAAA. ARN19702 has pain relief effects .

HY-B0906

Bucetin 3-Hydroxy-p-butyrophenetidide	Bacterial	Others
Bucetin (3-Hydroxy-p-butyrophenetidide) is an antipyretic compound and can also be used in pain relief studies.

HY-101789

Nav1.7-IN-3	Sodium Channel	Neurological Disease
Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC₅₀ of 8 nM. Pain relief. Limited CNS penetration .

HY-W152604

Cyclo(glycyl-L-leucyl) Cyclo(leu-gly)	Dopamine Receptor	Neurological Disease
Cyclo(glycyl-L-leucyl) (Cyclo(leu-gly)), a neuropeptide, down-regulates dopamine (DA) receptors and attenuates dopaminergic supersensitivity. Cyclo(glycyl-L-leucyl) inhibits the development of Morphine induced pain relief as well as dopamine receptor supersensitivity in rats. Cyclo(glycyl-L-leucyl) has the potential for the prevention of tardive and/or L-DOPA (HY-N0304)-induced dyskinesias .

HY-159837

Nispomeben	Others	Neurological Disease
Nispomeben is a potent non-opioid pain relief drug .

HY-137459

Vocacapsaicin CA-008	TRP Channel	Neurological Disease
Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief .

HY-117497

Simetride	Others	Neurological Disease
Simetride is an analgesic agent. Simeicui is used for pain relief .

HY-114945

CGRP antagonist 2	CGRP Receptor	Neurological Disease
CGRP antagonist 2 is a CGRP receptor antagonist. CGRP antagonist 2 can be used for pain relief .

HY-139068

Ibuprofen arginine	Drug Derivative	Others
Ibuprofen arginine is an orally active L-arginine of Ibuprofen (HY-78131). With rapid absorption and high bioavailability, Ibuprofen arginine can effectively relieve a variety of acute pain, and has little damage to gastric mucosa and is well tolerated. Ibuprofen arginine can be used in research for pain relief .

HY-19500

SC-75416	COX	Others
SC-75416 is a selective cyclooxygenase-2 inhibitor. Its pharmacokinetic/pharmacodynamic (PK/PD) model was used for development and clinical trial simulation to design a study protocol to verify its analgesic effect in a post-oral surgery pain model. The simulation results showed that 360 mg of SC-75416 may provide better pain relief than 400 mg of ibuprofen. The actual clinical trial results confirmed this hypothesis, and 360 mg of SC-75416 was indeed superior to 400 mg of ibuprofen in pain relief. The PK/PD model of SC-75416 showed good predictive performance and successfully predicted its clinical effect. These research results show that SC-75416, as a new selective COX-2 inhibitor, has potential clinical application value in the management of post-oral surgery pain.

HY-167734

Pemedolac AY-30715	COX	Inflammation/Immunology
Pemedolac (AY-30715) is a potent analgesic with significant pain-relief efficacy against chemically induced and inflammatory pain in animal models. Pemedolac displays a notable separation between analgesic effects and anti-inflammatory activity, achieving effective pain relief at much lower doses than those required for anti-inflammatory or gastric irritant effects. Pemedolac also shows low ulcerogenic potential, indicating a safer profile compared to standard NSAIDs while being utilized for the treatment of neurological, skin, and musculoskeletal disorders.

HY-101719

Ketocaine Rec 7-0518	Drug Derivative	Neurological Disease
Ketocaine is a butyrophenone derivative used topically for pain relief.

HY-137459A

Vocacapsaicin hydrochloride CA-008 hydrochloride	TRP Channel	Neurological Disease
Vocacapsaicin (CA-008) hydrochloride, a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin hydrochloride can provide meaningful and long-lasting pain relief .

HY-B0683S

Limaprost-d3	Isotope-Labeled Compounds PGE synthase	Cardiovascular Disease Inflammation/Immunology
Limaprost-d₃ (17α,20-dimethyl-δ2-PGE1-d₃) is the deuterium labeled Limaprost. Limaprost (OP1206) is a PGE1 analogue and a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost pain relief, has antianginal effects, and can be used for ischaemic symptoms research .

HY-W016586R

Acivicin (Standard) AT-125 (Standard); U-42126 (Standard)	Reference Standards Parasite γ-Glutamyl Transferase (GGT)	Infection Cancer
Articaine (Standard) is the analytical standard of Articaine. This product is intended for research and analytical applications. Articaine (Hoe-045 free base) is an amide agent that can suppress or relieve pain. containing an ester group, reversibly binding to the α-subunit of the voltage-gated sodium channels within the inner cavity of the nerve, can provide effective pain relief. Articaine ameliorates LPS-induced acute kidney injury via inhibition of NF-κB activation and the NLRP3 inflammasome pathway .

HY-N0701R

(-)-Asarinin (Standard)	Reference Standards Apoptosis Reactive Oxygen Species (ROS) STAT Src Stearoyl-CoA Desaturase (SCD) Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
(-)-Asarinin (Standard) is the analytical standard of (-)-Asarinin (HY-N0701). This product is intended for research and analytical applications. (-)-Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-)-Asarinin induces apoptosis in cancer cells. (-)-Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-)-Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-)-Asarinin is a non-competitive Δ5-desaturase inhibitor with a K_i of 0.28 mM. (-)-Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects.

HY-115851

Demethyl PL265	Endogenous Metabolite	Neurological Disease
Demethyl PL265 is an enduring dual ENKephalinase inhibitor (DENKi) that holds promise for pain relief.

HY-13597

CJ-15161	Opioid Receptor	Neurological Disease
CJ-15161 is a κ-opioid receptor agonist. CJ-15161 can be used to study physiological functions such as pain relief and emotional regulation .

HY-185388

Bupivacaine liposome Liposomal bupivacaine	Liposome iGluR Calcium Channel Potassium Channel Sodium Channel	Cancer
Bupivacaine liposome is a liposome-encapsulated form of Bupivacaine (HY-B0405). Bupivacaine is an NMDA receptor inhibitor. During the action potential, Bupivacaine blocks sodium channels, thereby inhibiting the generation and conduction of nerve impulses induced by painful stimuli. Bupivacaine liposome reduces the release rate of Bupivacaine, thus achieving a long-lasting pain relief effect.

HY-101789R

Nav1.7-IN-3 (Standard)	Reference Standards Sodium Channel	Neurological Disease
Nav1.7-IN-3 (Standard) is the analytical standard of Nav1.7-IN-3 (HY-101789). This product is intended for research and analytical applications. Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC₅₀ of 8 nM. Pain relief. Limited CNS penetration .

Cat. No.	Product Name

HY-L071

Alkaloids Library	599 compounds
Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds. MCE designs a unique collection of 599 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Alkaloids Library

599 compounds

Alkaloids are a large and complex group of cyclic compounds that contain N. About 2,000 different alkaloids have been isolated. Important alkaloids include morphine, strychnine, atropine, colchicine, ephedrine, quinine, and nicotine. Alkaloids are useful as diet ingredients, supplements, and pharmaceuticals, in medicine and in other applications in human life. They showed anti-inflammatory, anticancer, analgesics, local anesthetic and pain relief, neuropharmacologic, antimicrobial, antifungal, and many other activities. Alkaloids are also important compounds in organic synthesis for searching new semisynthetic and synthetic compounds with possibly better biological activity than parent compounds.

MCE designs a unique collection of 599 alkaloids that all come from natural products. MCE Alkaloids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Target	Research Area