CGRP antagonist 2
Based on 1 Customer Validation
CGRP antagonist 2 is a CGRP antagonist. CGRP antagonist 2 can be used in research on visceral pain and gastrointestinal disorders (such as functional bowel disorders and inflammatory bowel disease).
For research use only. We do not sell to patients.
- Purity : 99.73%
- CAS No.: 866086-05-7
- Formula: C35H47N5O6
- Molecular Weight:633.78
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
CGRP receptor[1]
In Vitro
CGRP antagonist 2 (Compound 12 on page 22) antagonizes CGRP and is used in irritable bowel syndrome research[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 866086-05-7
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Appearance Solid
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Molecular Weight 633.78
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Formula C35H47N5O6
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Color White to off-white
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SMILES
O=C(O[C@H](CC1=CC(C)=C(C(C)=C1)O)C(N2CCC(CC2)N3CCOCC3)=O)N4CCC(CC4)N5C(NC6=CC=CC=C6CC5)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (157.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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DSS-Induced Colitis
Dextran sulfate sodium (DSS)-induced colitis is generated by administering DSS in mouse drinking water, producing epithelial injury, barrier disruption, weight loss, diarrhea, fecal blood, colon shortening, histologic mucosal damage, and inflammatory mediator changes; the model is mainly used to study acute or chronic intestinal inflammation resembling selected features of ulcerative colitis. DSS injury is interpreted through clinical and tissue readouts rather than a single molecular endpoint: daily body weight, stool consistency, and bleeding are combined into a disease activity index, while colon length, histology, cytokines, myeloperoxidase activity, intestinal permeability, and tight-junction markers provide complementary measures of inflammation and barrier damage.
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TNBS-Induced Colitis
TNBS-induced colitis is produced by intrarectal delivery of 2,4,6-trinitrobenzene sulfonic acid in ethanol, where ethanol disrupts the mucosal barrier and TNBS haptenates colonic proteins, generating immune-mediated colonic inflammation with weight loss, diarrhea, ulceration, transmural injury, inflammatory-cell infiltration, and cytokine responses. The model is used as an experimental intestinal inflammation model with Crohn’s disease–like features, especially when Th1-type responses, IL-12–dependent inflammation, chronic relapsing inflammation, or fibrosis-related endpoints are studied.
Purity & Documentation
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Data Sheet (291 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.5778 mL | 7.8892 mL | 15.7783 mL | 39.4459 mL |
| 5 mM | 0.3156 mL | 1.5778 mL | 3.1557 mL | 7.8892 mL | |
| 10 mM | 0.1578 mL | 0.7889 mL | 1.5778 mL | 3.9446 mL | |
| 15 mM | 0.1052 mL | 0.5259 mL | 1.0519 mL | 2.6297 mL | |
| 20 mM | 0.0789 mL | 0.3945 mL | 0.7889 mL | 1.9723 mL | |
| 25 mM | 0.0631 mL | 0.3156 mL | 0.6311 mL | 1.5778 mL | |
| 30 mM | 0.0526 mL | 0.2630 mL | 0.5259 mL | 1.3149 mL | |
| 40 mM | 0.0394 mL | 0.1972 mL | 0.3945 mL | 0.9861 mL | |
| 50 mM | 0.0316 mL | 0.1578 mL | 0.3156 mL | 0.7889 mL | |
| 60 mM | 0.0263 mL | 0.1315 mL | 0.2630 mL | 0.6574 mL | |
| 80 mM | 0.0197 mL | 0.0986 mL | 0.1972 mL | 0.4931 mL | |
| 100 mM | 0.0158 mL | 0.0789 mL | 0.1578 mL | 0.3945 mL |
CGRP antagonist 2 Related Classifications
HY-114945 Related Classifications
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