Cat. No.: HY-N3074

Hexahydrofarnesyl acetone

(Synonyms: 6,10,14-Trimethyl-2-pentadecanone)

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Hexahydrofarnesyl acetone (6,10,14-Trimethyl-2-pentadecanone) is a oral active sesquiterpene with oral activity, exhibiting antibacterial, anti-inflammatory, and anticancer properties, and is used in pain relief research.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 502-69-2
Formula: C₁₈H₃₆O
Molecular Weight:268.48

Storage:

Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Hexahydrofarnesyl acetone Chemical Structure

CAS No.: 502-69-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

The essential oil of Lindera nacusua (containing 6.83% Hexahydrofarnesyl acetone, 0.2 mg of essential oil, 0.1 mL microbial suspension, 24 hours) exhibits significant antibacterial activity against Staphylococcus aureus and Candida albicans, with inhibition zones reaching 2.5 mm and 2.0 mm, respectively, surpassing the positive control, Amoxicillin (HY-B0467A)^[2].
The essential oil of Graptophyllum pictum (containing 2.6% Hexahydrofarnesyl acetone, 5 μL of essential oil, 3, 4, or 5 days) shows significant cytotoxicity against KB cells (epidermoid carcinoma of oral cavity), NCI-H187 cells (small cell lung carcinoma), and Vero cells (African green monkey kidney)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[3]

Cell Line:

KB cells (epidermoid carcinoma oforal cavity), MCF-7 cells (breast adenocarcinoma), NCI-H187 cells (small cell lung carcinoma) and Vero cells (the African green monkey kidney)
Concentration:

5 μL (administered as essential oil containing 2.6% Hexahydrofarnesyl acetone)
Incubation Time:

3 (KB and MCF-7 cells), 4 (Vero cells) or 5 (NCI-H187 cells) days
Result:

Had the IC₅₀ values of 27.04, 25.27, and 26.52 µg/mL against KB cells, NCI-H187 cells, and Vero cells, respectively.

In Vivo

The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) inhibits carrageenan (HY-125474)-induced inflammation in the paw edema model of Wistar rats^[1].
The essential oil of Albizia zygia (containing 33.14% Hexahydrofarnesyl acetone, 100, 200, 400 mg/kg, p.o., single dose) exhibits analgesic effects in the formalin-induced pain model in Wistar rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Carrageenan (HY-125474)-induced paw edema model in Wistar rats (150-200 g)^[1]
Dosage:

100, 200, 400 mg/kg
Administration:

Oral gavage (p.o.), single dose
Result:

Exerted a significant dose-dependent inhibitory effect on the development of carrageenan (HY-125474)-induced paw swelling.

Animal Model:

Formalin-induced pain model in Wistar rats (150-200 g)^[1]
Dosage:

100, 200, 400 mg/kg
Administration:

Oral gavage (p.o.), single dose
Result:

Increased the tolerance of rats to Formalin-induced pain.

Chemical Information

CAS No. 502-69-2
Appearance Liquid (Density: 0.8403 g/cm³)
Molecular Weight 268.48
Formula C₁₈H₃₆O
Color Colorless to light yellow
SMILES

CC(CCCC(C)CCCC(C)CCCC(C)C)=O
Synonyms

6,10,14-Trimethyl-2-pentadecanone
Structure Classification
- Others
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (124.14 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7247 mL

18.6234 mL

37.2467 mL

5 mM

0.7449 mL

3.7247 mL

7.4493 mL

10 mM

0.3725 mL

1.8623 mL

3.7247 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (9.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (9.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (9.31 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Opeyemi N Avoseh, et al.Albizia lebbeck and Albizia zygia volatile oils exhibit anti-nociceptive and anti-inflammatory properties in pain models.J Ethnopharmacol. 2021 Mar 25;268:113676 [Content Brief]

[2]. Guoqing Wei, et al. Essential oil composition and antibacterial activity of Lindera nacusua (D. Don) Merr. Nat Prod Res. 2016 Dec;30(23):2704-2706. [Content Brief]

[3]. Jiangseubchatveera N, et al. The Chemical Constituents and the Cytotoxicity, Antioxidant and Antibacterial Activities of the Essential Oil of Graptophyllum pictum (L.) Griff[J]. Journal of Essential Oil Bearing Plants, 2015, 18(1): 11-17.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7247 mL	18.6234 mL	37.2467 mL	93.1168 mL
	5 mM	0.7449 mL	3.7247 mL	7.4493 mL	18.6234 mL
	10 mM	0.3725 mL	1.8623 mL	3.7247 mL	9.3117 mL
	15 mM	0.2483 mL	1.2416 mL	2.4831 mL	6.2078 mL
	20 mM	0.1862 mL	0.9312 mL	1.8623 mL	4.6558 mL
	25 mM	0.1490 mL	0.7449 mL	1.4899 mL	3.7247 mL
	30 mM	0.1242 mL	0.6208 mL	1.2416 mL	3.1039 mL
	40 mM	0.0931 mL	0.4656 mL	0.9312 mL	2.3279 mL
	50 mM	0.0745 mL	0.3725 mL	0.7449 mL	1.8623 mL
	60 mM	0.0621 mL	0.3104 mL	0.6208 mL	1.5519 mL
	80 mM	0.0466 mL	0.2328 mL	0.4656 mL	1.1640 mL
	100 mM	0.0372 mL	0.1862 mL	0.3725 mL	0.9312 mL

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Hexahydrofarnesyl acetone

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All Antibiotic Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Hexahydrofarnesyl acetone Related Classifications

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