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prostate carcinoma and breast cancer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (1) Akt (3) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (6) Bcl-2 Family (1) Caspase (2) Drug Derivative (1) EGFR (1) ERK (1) FAK (1) Gli (1) GSK-3 (1) Hedgehog (1) Histone Demethylase (1) Methionine Adenosyltransferase (MAT) (1) NF-κB (1) p38 MAPK (1) Phytohormone (1) Pim (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Ribosomal S6 Kinase (RSK) (1) TNF Receptor (1) Topoisomerase (2)
By Research Areas:	Cancer (15) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1)

By Targets:

ADC Payload (1)

Akt (3)

Antibody-Drug Conjugates (ADCs) (1)

Apoptosis (6)

Bcl-2 Family (1)

Caspase (2)

Drug Derivative (1)

EGFR (1)

ERK (1)

FAK (1)

Gli (1)

GSK-3 (1)

Hedgehog (1)

Histone Demethylase (1)

Methionine Adenosyltransferase (MAT) (1)

NF-κB (1)

p38 MAPK (1)

Phytohormone (1)

Pim (1)

RAR/RXR (1)

Reactive Oxygen Species (ROS) (2)

Ribosomal S6 Kinase (RSK) (1)

TNF Receptor (1)

Topoisomerase (2)

By Research Areas:

Cancer (15)

Infection (1)

Inflammation/Immunology (1)

Metabolic Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Targets Recommended: BCRP PSMA BRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-119272

EF24 2 Publications Verification	ERK Caspase NF-κB Apoptosis p38 MAPK Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
EF24, a curcumin analogue, is an NF-kB inhibitor with great anti-tumor efficacy and oral bioavailability via deactivation of the MAPK/ERK signaling pathway in oral squamous cell carcinoma (OSCC). EF24 is active against melanoma and breast cancer cell lines with GI₅₀ values of 0.7 μM and 0.8 μM, respectively. EF24 induces cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells and DU-145 human prostate cancer cells. EF24 increases the levels of activated caspase 3 and 9, and decreases the phosphorylated forms of MEK1 and ERK .

HY-139434

JMJD6-IN-1	Histone Demethylase	Cancer
JMJD6-IN-1 is a JMJD6 inhibitor, with an inhibition rate of 82% at 10 μM. JMJD6-IN-1 inhibits MCF-7 and HCC4006 cell proliferation with IC₅₀ values of 19.2 μM and 25.2 μM. JMJD6-IN-1 inhibits JMJD6 demethylase activity. JMJD6-IN-1 can be used for the research of lung adenocarcinoma, prostate cancer, breast cancer, pancreatic cancer, colon cancer, oral squamous cell carcinoma, and glioblastoma .

HY-147785

Pim-1 kinase inhibitor 2 1 Publications Verification	Pim Caspase Bcl-2 Family Apoptosis	Cancer
Pim-1 kinase inhibitor 2 is a PIM-1 kinase inhibitor with a human IC₅₀ of 0.63 μM. Pim-1 kinase inhibitor 2 exhibits high selectivity for cancer cells over normal cells. Pim-1 kinase inhibitor 2 induces apoptosis, increases active caspase-3 levels, upregulates BAX, downregulates Bcl-2, and elevates the Bax/Bcl-2 ratio. Pim-1 kinase inhibitor 2 suppresses cancer cell proliferation and induces cell cycle arrest. Pim-1 kinase inhibitor 2 can be used for the research of prostate carcinoma, hepatocellular carcinoma, and breast adenocarcinoma .

HY-121435

K-8012	RAR/RXR Akt Apoptosis Drug Derivative TNF Receptor	Cancer
K-8012 is a Sulindac (HY-B0008) analog and RXRα antagonist with an IC₅₀ of 9.2 µM. K-8012 inhibits the activation of AKT. K-8012 induces Apoptosis, redirecting the TNFα signaling pathway from survival to death. K-8012 exerts anticancer activity against lung cancer, prostate cancer, and breast cancer. K-8012 can be used in research related to lung cancer, prostate cancer, breast cancer, and hepatocellular carcinoma .

HY-13787

XL-418	Akt Ribosomal S6 Kinase (RSK) GSK-3	Cancer
XL-418 is an orally active dual Akt and p70S6K inhibitor with IC₅₀s of 1 nM for Akt1 and 2 nM for p70S6K. XL-418 inhibits the phosphorylation of ribosomal protein S6 and GSK3β. XL-418 can be used for the study of prostate carcinoma and breast cancer .

HY-N13772

3'-O-Methyltaxifolin (+)-Dihydroisorhamnetin	Apoptosis	Cancer
3'-O-Methyltaxifolin ((+)-Dihydroisorhamnetin) is a dihydroflavanol found in Pulicaria jaubertii. A mixture of these alcohol compounds including 3'-O-Methyltaxifolin found in Pulicaria jaubertii exhibits antitumor activity with IC₅₀ values of 19.1 μg, 20.0 μg, and 24.1 μg against prostate cancer (PC-3), breast cancer (MCF-7), and hepatocellular carcinoma (HepG-2) cell lines, respectively. Furthermore, 3'-O-Methyltaxifolin can induce cell apoptosis, making it a promising candidate for anticancer research. .

HY-P99881

Rolinsatamab talirine ABBV 176	Antibody-Drug Conjugates (ADCs)	Cancer
Rolinsatamab talirine (ABBV 176) is a prolactin receptor (PRLR)-targeting antibody-drug conjugate (ADC), compoused of Rolinsatamab (HY-P99238) and SGD-1882 (HY-101127). Rolinsatamab talirine binds to PRLR to deliver a cytotoxin to tumor cells. Rolinsatamab talirine induces DNA damage, and exhibits cytotoxicity against multiple breast tumor models, including triple negative and low PRLR-expressing models. Rolinsatamab talirine demonstrates enhanced anti-tumor activity in several breast cancer models. Rolinsatamab talirine can be used for the research of breast cancer, hepatocellular carcinoma, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, adrenocortical carcinoma, and solid tumors .

HY-107408

SANT 2	Hedgehog Gli	Metabolic Disease Cancer
SANT 2 is a potent Hh-signaling pathway antagonist. SANT 2 interferes with the expression of Gli1. SANT 2 causes developmental delay in medaka embryos. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers .

HY-131438

GI-149893	Topoisomerase	Cancer
GI-149893 is a selective topoisomerase I (TopoI) inhibitor. GI-149893 prevents DNA religation and induces irreversible DNA damage in tumor cells. GI-149893 is promising for research of cancers (e.g., colon carcinoma HT-29/SW-48, breast MX-1, prostate PC-3 xenografts) .

HY-122844B

Ifebemtinib tosylate BI-853520 tosylate; IN-10018 tosylate	FAK	Cancer
Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor. Ifebemtinib (tosylate) demonstrates anti-tumor activity. Ifebemtinib (tosylate) inhibits FAK autophosphorylation in prostate carcinoma cells. Ifebemtinib (tosylate) can inhibit spheroid formation and orthotopic tumor growth in vivo. Ifebemtinib (tosylate) can be studied in anticancer research such as solid tumors, breast cancer, and malignant pleural mesothelioma .

HY-181166

EGFR-IN-194	EGFR Apoptosis	Cancer
EGFR-IN-194 is a potent EGFR tyrosine kinase inhibitor with an IC₅₀ of 54.3 nM against human EGFR. EGFR-IN-194 induces apoptosis, inhibits migration in cancer cells, selectively promotes invasion in cancer cells, and exhibits antiproliferative effects across multiple cancer cell lines. EGFR-IN-194 can be used for the research of prostate adenocarcinoma, non-small cell lung carcinoma, breast carcinoma, chronic myeloid leukemia .

HY-181285

MAT2A ligand 1	Methionine Adenosyltransferase (MAT)	Cancer
MAT2A ligand 1 is a MAT2A ligand inhibitor (IC₅₀₌29.5 nM) and PET tracer that crosses the blood-brain barrier. MAT2A ligand 1 enables non-invasive imaging of MAT2A-expressing tumors, with rapid tumor uptake equilibrium, a high tumor-to-muscle ratio, and specific tumor-binding properties. MAT2A ligand 1 is applicable to research related to non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, gastric cancer, glioblastoma, pancreatic adenocarcinoma, urothelial carcinoma, breast cancer, and prostate cancer .

HY-N13800

3-O-Debenzoylzeylenone	Phytohormone	Infection Cancer
3-O-Debenzoylzeylenone is a polyoxygenated cyclohexene plant growth hormone that exists in the leaves of Uvaria purpurea and the aerial parts of Uvaria grandiflora. 3-O-Debenzoylzeylenone is an auxin analog that inhibits root growth and promotes shoot growth of Lactuca sativa seedlings. 3-O-Debenzoylzeylenone exhibits cytotoxicity against various cancer cells and can be used in studies related to lung cancer, melanoma, epidermoid carcinoma, liver cancer, gastric cancer, colon adenocarcinoma, acute leukemia, breast cancer, and prostate cancer .

HY-182003

Anticancer agent 308	Akt Apoptosis Reactive Oxygen Species (ROS)	Cancer
Anticancer agent 308 is an AKT inhibitor with antitumor activity. Anticancer agent 308 reduces total AKT protein levels, thereby inhibiting the pro-survival PI3K/AKT signaling pathway. Anticancer agent 308 induces apoptosis, disrupts mitochondrial membrane potential, promotes ROS accumulation in mitochondria, and induces cell cycle arrest. Anticancer agent 308 inhibits cancer cell migration. Anticancer agent 308 is applicable to research related to breast cancer, lung adenocarcinoma, cervical cancer, prostate cancer, and hepatocellular carcinoma .

HY-183912

PY-4Car2	Topoisomerase ADC Payload	Cancer
PY-4Car2 is a Camptothecin (HY-16560) derivative and a topoisomerase I inhibitor. PY-4Car2 functions as a warhead conjugated via a cleavable linker to the bispecific ADC TJ101. PY-4Car2 can be used as an ADC payload for the research of cancers _.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99881

Rolinsatamab talirine ABBV 176	Antibody-Drug Conjugates (ADCs)	Cancer
Rolinsatamab talirine (ABBV 176) is a prolactin receptor (PRLR)-targeting antibody-drug conjugate (ADC), compoused of Rolinsatamab (HY-P99238) and SGD-1882 (HY-101127). Rolinsatamab talirine binds to PRLR to deliver a cytotoxin to tumor cells. Rolinsatamab talirine induces DNA damage, and exhibits cytotoxicity against multiple breast tumor models, including triple negative and low PRLR-expressing models. Rolinsatamab talirine demonstrates enhanced anti-tumor activity in several breast cancer models. Rolinsatamab talirine can be used for the research of breast cancer, hepatocellular carcinoma, ovarian cancer, endometrial cancer, prostate cancer, colorectal cancer, adrenocortical carcinoma, and solid tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N13772

3'-O-Methyltaxifolin (+)-Dihydroisorhamnetin	Flavanonols Flavonoids Pulicaria jaubertii E.Gamal-Eldin Asteraceae Plants Source Classification	Apoptosis
3'-O-Methyltaxifolin ((+)-Dihydroisorhamnetin) is a dihydroflavanol found in Pulicaria jaubertii. A mixture of these alcohol compounds including 3'-O-Methyltaxifolin found in Pulicaria jaubertii exhibits antitumor activity with IC₅₀ values of 19.1 μg, 20.0 μg, and 24.1 μg against prostate cancer (PC-3), breast cancer (MCF-7), and hepatocellular carcinoma (HepG-2) cell lines, respectively. Furthermore, 3'-O-Methyltaxifolin can induce cell apoptosis, making it a promising candidate for anticancer research. .

HY-N13800

3-O-Debenzoylzeylenone	Structural Classification Uvaria grandiflora Roxb. Other Phenylpropanoids Phenylpropanoids Plants Annonaceae Source Classification	Phytohormone
3-O-Debenzoylzeylenone is a polyoxygenated cyclohexene plant growth hormone that exists in the leaves of Uvaria purpurea and the aerial parts of Uvaria grandiflora. 3-O-Debenzoylzeylenone is an auxin analog that inhibits root growth and promotes shoot growth of Lactuca sativa seedlings. 3-O-Debenzoylzeylenone exhibits cytotoxicity against various cancer cells and can be used in studies related to lung cancer, melanoma, epidermoid carcinoma, liver cancer, gastric cancer, colon adenocarcinoma, acute leukemia, breast cancer, and prostate cancer .

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