3-O-Debenzoylzeylenone 

3-O-Debenzoylzeylenone is a polyoxygenated cyclohexene plant growth hormone that exists in the leaves of Uvaria purpurea and the aerial parts of Uvaria grandiflora. 3-O-Debenzoylzeylenone is an auxin analog that inhibits root growth and promotes shoot growth of Lactuca sativa seedlings. 3-O-Debenzoylzeylenone exhibits cytotoxicity against various cancer cells and can be used in studies related to lung cancer, melanoma, epidermoid carcinoma, liver cancer, gastric cancer, colon adenocarcinoma, acute leukemia, breast cancer, and prostate cancer^[1][2].

3-O-Debenzoylzeylenone (50 ppm; 5 days) inhibits root growth of lettuce (Lactuca sativa) by up to 64.5% and promotes its stem growth by up to 19.6%^[1].
3-O-Debenzoylzeylenone (compound 1) exhibits significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines (with IC₅₀ values of 4.68 and 3.63 μM, respectively), shows moderate cytotoxicity against a variety of other cancer cell lines, and displays only weak to extremely weak cytotoxicity against the MDA-BA-231, LNCaP and normal 3T3 cell lines^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

278.26

C₁₄H₁₄O₆

1800008-77-8

O=C(C1=CC=CC=C1)OC[C@@]2([C@H]([C@@H](C=CC2=O)O)O)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Takeuchi Y, et al. Polyoxygenated cyclohexenes from the Chinese tree, Uvaria purpurea. Biosci Biotechnol Biochem. 2002;66(3):537-542.  [Content Brief]

  [2]. Ho DV, et al. A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora. Bioorg Med Chem Lett. 2015;25(16):3246-3250.  [Content Brief]