Search Result

Results for "

sphingolipid metabolism

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (2) Amyloid-β (1) Apoptosis (2) ATM/ATR (1) Autophagy (2) Biochemical Assay Reagents (3) Ceramidase (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (5) Ferroptosis (1) Fungal (2) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) Liposome (1) mTOR (1) NF-κB (1) Notch (1) Parasite (1) PTEN (1) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Topoisomerase (1) VEGFR (1) γ-secretase (1)
By Research Areas:	Cancer (3) Infection (3) Inflammation/Immunology (2) Metabolic Disease (9) Neurological Disease (4)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: Mitochondrial Metabolism

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113498

Sphingomyelin 1 Publications Verification	Endogenous Metabolite	Neurological Disease Metabolic Disease Inflammation/Immunology
Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann–Pick disease .

HY-N11709

Theasaponin E1	Apoptosis VEGFR ATM/ATR PTEN Akt mTOR HIF/HIF Prolyl-Hydroxylase NF-κB Notch Cholinesterase (ChE) Amyloid-β γ-secretase Ferroptosis Fungal	Infection Neurological Disease Metabolic Disease Cancer
Theasaponin E1 is an orally effective tea saponin. Theasaponin E1 inhibits the proliferation of cancer cells by activating apoptosis. Theasaponin E1 inhibits angiogenesis in ovarian cancer cells and HUVECs by reducing the expression of VEGF. Theasaponin E1 upregulates the phosphorylation level of ATM protein and the expression level of PTEN protein in cancer cells, decreases the phosphorylation levels of Akt, mTOR, p70S6K and 4E-BP1 proteins, downregulates the expression of HIF-1α and NF-κB, and reduces the protein expression of Notch ligands Dll4 and Jagged1. Theasaponin E1 exerts neuroprotective effects by inhibiting the activity of acetylcholinesterase, activating α-secretase and neprilysin, reducing the concentration of Aβ, and inhibiting the activities of β-secretase and γ-secretase. Theasaponin E1 exhibits toxic effects on cancer cells and quinone reductase-inducing activity, and inhibits tumor growth in vivo. Theasaponin E1 induces ferroptosis in Pomacea canaliculata by synergistically disrupting cholesterol homeostasis and sphingolipid metabolism. Theasaponin E1 possesses anti-biofilm activity against Candida albicans. Theasaponin E1 can be used in the research of ovarian cancer, obesity, Alzheimer's disease and fungal infections .

HY-139286

Photoclick sphingosine Pacsph; Pacsphingosine (d18:1)	Biochemical Assay Reagents	Others
Photoclick sphingosine (Pacsph) is a photosensitizing and clickable sphingosine analog. Photoclick sphingosine is metabolized in cells into endogenous lipid metabolic pathways and can be visualized by its clickable alkyne group. Photoclick sphingosine can be used to study intracellular sphingolipid metabolism and subcellular localization .

HY-178174

MGB4	DNA/RNA Synthesis Topoisomerase	Cancer
MGB4 is a DNA minor groove binder. MGB4 binds to ARE-containing DNA and inhibition of topoisomerase I activity. MGB4 can impacts key cellular pathways, including inhibition oftranslation and alterations in sphingolipid and amino acid metabolism. MGB4 also reduces spermine and spermidine metabolism companied with Doxorubicin (HY-15142A). MGB4 can be used for the research of cancer, such as Prostate cancer .

HY-168764

C16 Galactosylceramide	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
C16 Galactosylceramide is a sphingolipid compound. C16 Galactosylceramide participates in the physiological processes of lipid metabolism and immune regulation in cells. C16 Galactosylceramide can be used in the study of diabetes .

HY-W158234

N-Methylbenzo[d]oxazol-2-amine	Parasite	Infection
N-Methylbenzo[d]oxazol-2-amine (compound 1) is an anthelmintic activity and lower cytotoxicity against T. spiralis adult worm. N-Methylbenzo[d]oxazol-2-amine up-regulates the metabolism of purine, pyrimidine and down-regulates sphingolipid metabolism .

HY-119327

Butylate	Autophagy AMPK	Others
Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.

HY-119327R

Butylate (Standard)	Autophagy AMPK Reference Standards	Others
Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.

HY-N7697R

Chitotetraose tetrahydrochloride (Standard)	Reference Standards Others	Others
Butylate (Standard) is the analytical standard of Butylate. This product is intended for research and analytical applications. Butylate is a compound involved in platelet research. Platelet activation can cause autophagy, which is partly mediated by the AMPK-MTOR pathway and is related to sphingolipid metabolism. Butylate mentioned in the study may be a tool or control substance for studying related metabolic processes.

HY-173540

C22:1 1-Deoxyceramide (m18:1/22:1) C22:1(13Z) 1-Deoxyceramide	Ceramidase	Neurological Disease
C22:1 1-Deoxyceramide (m18:1/22:1) (C22:1(13Z) 1-Deoxyceramide) is a deoxyceramide lipid that lacks the 1-hydroxyl group and is a ceramide variant. C22:1 1-Deoxyceramide (m18:1/22:1) has potential neurotoxicity and is involved in mitochondrial stress and cell death signaling. It can be used to study abnormal sphingolipid metabolism and neurodegenerative diseases .

HY-168066

Antifungal agent 117	Fungal	Infection
Antifungal agent 117 is a bis-pyrazole carboxamide derivative with antifungal activity, exhibiting an EC₅₀ value of 11.58 mg/L against Sclerotinia sclerotiorum. Antifungal agent 117 increases cell membrane permeability, causing an imbalance in osmotic pressure inside and outside the cell, and induces the accumulation of reactive oxygen species (ROS), leading to oxidative damage to the cell membrane, resulting in leakage of cellular contents and eventually cell death. RNA sequencing analysis reveals that Antifungal agent 117 downregulates catalase genes and upregulates neutral ceramidase genes, disrupting cell membrane structure, accelerating sphingolipid metabolism, and promoting cell death. Antifungal agent 117 shows great potential in the fields of plant protection and antifungal infection .

HY-N16342

N-C16-Desoxymethylsphinganine	Others	Others
N-C16-desoxymethylsphinganine is an effective inhibitor of sphingolipid metabolism.

HY-N16335

N-C24:1-Desoxymethylsphinganine	Others	Others
N-C24:1-desoxymethylsphinganine is an effective inhibitor of sphingolipid metabolism.

HY-121683A

2-Hexadecenal (E/Z)-16:1 Aldehyde	Apoptosis Reactive Oxygen Species (ROS)	Metabolic Disease
2-Hexadecenal, a long-chain fatty aldehyde, is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorganization, DNA damage, and apoptosis. 2-Hexadecenal regulates ROS production and induces apoptosis in polymorphonuclear leucocytes.

HY-121683S

2-Hexadecenal-d5 16:1 Aldehyde-d₅	Isotope-Labeled Compounds	Metabolic Disease
2-Hexadecenal-d₅ is the deuterated 2-Hexadecenal. 2-Hexadecenal, a long-chain fatty aldehyde, is a byproduct of sphingolipid metabolism, involved in cytoskeletal reorganization, DNA damage, and apoptosis.

HY-E70940A

Sphingomyelinase, Streptomyces sp.	Endogenous Metabolite	Metabolic Disease
Sphingomyelinase, Streptomyces sp. (EC 3.1.4.12) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. Sphingomyelinase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide.

HY-E70940

Sphingomyelinase, Staphylococcus aureus	Endogenous Metabolite	Metabolic Disease
Sphingomyelinase, Staphylococcus aureus (EC 3.1.4.12) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. Sphingomyelinase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide.

HY-E70940B

Sphingomyelinase, Bacillus cereus	Biochemical Assay Reagents	Metabolic Disease
Sphingomyelinase, Bacillus cereus (EC 3.1.4.12) is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. Sphingomyelinase, Bacillus cereus (EC 3.1.4.12) is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide.

HY-128395

C20-Dihydrosphingomyelin C20-DHSM; DHSM (d18:0/20:0)	Liposome Endogenous Metabolite	Metabolic Disease
C20-Dihydrosphingomyelin (C20-DHSM; DHSM (d18:0/20:0)) is a saturated form of Sphingomyelin (HY-113498). C20-Dihydrosphingomyelin is a secondary component of most cell sphingolipids and its levels significantly decrease after intermittent fasting during Ramadan. C20-Dihydrosphingomyelin can be used for the development of liposome reagents .

HY-148747

Ganglioside GD3 (d18:1/12:0)	Biochemical Assay Reagents	Neurological Disease Cancer
Ganglioside GD3 (d18:1/12:0) is a type of glycosphingolipid, the d18:1 indicates the sphingosine base, and the 12:0 represents the fatty acid part which is lauric acid. Ganglioside GD3 (d18:1/12:0) is a crucial intermediate in the biosynthesis pathway of gangliosides and is mainly found in the brain tissues of mammals. Ganglioside GD3 (d18:1/12:0) plays significant roles in development, cell signal transduction, and various diseases .

HY-164158

N,N-Dimethyl psychosine	Drug Derivative	Others
N,N-Dimethyl psychosine is a derivative of Psychosine (HY-136490). N,N-Dimethyl psychosine can be used as an internal standard compound to quantify Psychosine in alkaline-treated lipid extracts .

Cat. No.	Product Name

HY-L091

Lipid Metabolism Compound Library	978 compounds
Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation. MCE offers a unique collection of 978 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Lipid Metabolism Compound Library

978 compounds

Lipids are a fundamental class of organic molecules implicated in a wide range of biological processes, and based on this can be broadly classified into five categories: fatty acids, triacylglycerols (TAGs), phospholipids, sterol lipids and sphingolipids. Lipids play a crucial role in different metabolic pathways and cellular functions. Lipid metabolism is an important physiological process that is related to nutrient adjustment, hormone regulation, and homeostasis. Lipid metabolism dysregulation is associated with many diseases such as obesity, liver disease, aging and inflammation.

MCE offers a unique collection of 978 compounds related to lipid metabolism, which target relevant targets in the process of lipid metabolism, such as ATGL, MAGL, FAAH, acetyl-Coa Carboxylase, FASN, etc. MCE lipid metabolism compound library is a useful tool for research lipid metabolism and drug discovery of diseases related to lipid metabolism.

Cat. No.	Product Name	Category	Target	Chemical Structure