tanshinone

By Targets:	Autophagy (1) Beta-secretase (1) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) CRAC Channel (1) Drug Metabolite (1) Phosphatase (1) Phospholipase (1) SARS-CoV (1) STAT (1) VEGFR (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (3) Infection (1) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N1370

Tanshinone IIA sulfonate sodium 5 Publications Verification Sodium tanshinone IIA sulfonate; tanshinone IIA sodium sulfonate	CRAC Channel	Cardiovascular Disease Cancer
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca ²⁺ entry (SOCE), and is used to treat cardiovascular disorders.

HY-N1179

Tanshinone IIB
Tanshinone IIB is a major active constituent of the roots of Salvia miltiorrhiza (Danshen) widely used for the research of stroke and coronary heart disease in Asian countries. Tanshinone IIB has a neuroprotective effect via inhibition of apoptosis .

HY-N0134

Tanshinone I 1 Publications Verification tanshinone A	Phospholipase	Cardiovascular Disease Cancer
Tanshinone I is an inhibitor of type IIA human recombinant sPLA₂ (IC₅₀=11 μM) and rabbit recombinant cPLA₂ (IC₅₀=82 μM).

HY-N0135

Tanshinone IIA 10+ Cited Publications Dan Shen ketone	VEGFR	Cardiovascular Disease Cancer
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-N10686

Tanshinone IIA anhydride	Cholinesterase (ChE)	Cancer
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-N0174

Cryptotanshinone Maximum Cited Publications 34 Publications Verification Cryptotanshinon; tanshinone c	STAT Autophagy	Cancer
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N7177

Hydroxytanshinone IIA	Drug Metabolite VEGFR	Cancer
Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2 .

HY-N7761

Trijuganone B Tetrahydro tanshinone I	Others	Cancer
Trijuganone B (Tetrahydro tanshinone I) can be extracted from from the roots of Salvia miltiorrhiza f. alba. Trijuganone B inhibits the proliferation of leukemia cells .

HY-N3734

Deoxyneocryptotanshinone	Beta-secretase Phosphatase	Neurological Disease
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .

HY-NP001

Cationic Bovine Serum Albumin cBSA, chemically modified cationic bovine serum albumin	Biochemical Assay Reagents	Neurological Disease
Cationic Bovine Serum Albumin is a 583 amino acid protein consisting of three homologous full alpha structural domains. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .

HY-N10908

Tanshinoic acid A

Others Others

Tanshinoic acid A, a oxidic tanshinone diterpenoid, is a 11,12-seco-tanshinone derivative .

Tanshinoic acid A	Others	Others
Tanshinoic acid A, a oxidic tanshinone diterpenoid, is a 11,12-seco-tanshinone derivative .

HY-126416

Methyl tanshinonate	SARS-CoV	Infection Metabolic Disease
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of M ^pro enzyme in SARS-CoV (IC₅₀ = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research .

Cat. No.	Product Name	Type

HY-NP001

Cationic Bovine Serum Albumin cBSA, chemically modified cationic bovine serum albumin	Native Proteins
Cationic Bovine Serum Albumin is a 583 amino acid protein consisting of three homologous full alpha structural domains. Cationic Bovine Serum Albumin has remarkable neuroprotective effects on ischemic stroke when in combination with Tanshinone IIA (HY-N0135) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1370

Tanshinone IIA sulfonate sodium 5 Publications Verification Sodium tanshinone IIA sulfonate; tanshinone IIA sodium sulfonate	Classification of Application Fields Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Cancer	CRAC Channel
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca ²⁺ entry (SOCE), and is used to treat cardiovascular disorders.

HY-N0134

Tanshinone I 1 Publications Verification tanshinone A	Classification of Application Fields Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Cancer	Phospholipase
Tanshinone I is an inhibitor of type IIA human recombinant sPLA₂ (IC₅₀=11 μM) and rabbit recombinant cPLA₂ (IC₅₀=82 μM).

HY-N0135

Tanshinone IIA 10+ Cited Publications Dan Shen ketone	Quinones Structural Classification Classification of Application Fields Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants Naphthalene Quinones Disease Research Fields Cancer	VEGFR
Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.

HY-N0174

Cryptotanshinone Maximum Cited Publications 34 Publications Verification Cryptotanshinon; tanshinone c	Quinones Structural Classification Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Plants Naphthalene Quinones Disease Research Fields Cancer	STAT Autophagy
Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC₅₀ of 4.6 μM.

HY-N10686

Tanshinone IIA anhydride	Structural Classification Flavonoids Labiatae Source classification Samanea saman (Jacq.) Merr. Plants Other Flavonoids	Cholinesterase (ChE)
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-N7177

Hydroxytanshinone IIA	Quinones Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Plants Naphthalene Quinones Disease Research Fields Cancer	Drug Metabolite VEGFR
Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2 .

HY-N3734

Deoxyneocryptotanshinone	Structural Classification Terpenoids Labiatae Samanea saman (Jacq.) Merr. Diterpenoids Plants	Beta-secretase Phosphatase
Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC₅₀ value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research .

HY-N10908

Tanshinoic acid A	Structural Classification Natural Products Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	Others
Tanshinoic acid A, a oxidic tanshinone diterpenoid, is a 11,12-seco-tanshinone derivative .

HY-126416

Methyl tanshinonate	Structural Classification Natural Products Labiatae Source classification Samanea saman (Jacq.) Merr. Plants	SARS-CoV
Methyl tanshinonate is a tanshinone, that can be isolated from Salvia miltiorrhiza (S. miltiorrhiza) Bunge (Lamiaceae). Methyl tanshinonate is a potent inhibitor of M ^pro enzyme in SARS-CoV (IC₅₀ = 21.1 µM). Methyl tanshinonate can be used for diabetes and SARS-CoV research .

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