Tanshinone IIA sulfonate sodium
Based on 7 publication(s) in Google Scholar
Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 69659-80-9
- Formula: C19H17NaO6S
- Molecular Weight:396.39
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Storage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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HY-N0135
Tanshinone IIA
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HY-N0431
Astragaloside IV
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HY-18085
Quercetin
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HY-N0174
Cryptotanshinone
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HY-N1067
Xanthohumol
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HY-N0401A
(Z)-Ligustilide
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HY-N0134
Tanshinone I
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HY-N0052A
Sanguinarine chloride
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HY-N1370R
Tanshinone IIA sulfonate sodium (Standard)
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HY-113618B
RO2959 monohydrochloride
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HY-110028
Leelamine hydrochloride
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HY-100831
YM-58483
Publications Citing Use of MedChemExpress (MCE) Tanshinone IIA sulfonate sodium
More- J Adv Res. 2025 Mar:69:313-327. [Abstract]
- Int Immunopharmacol. 2023 May:118:110111. [Abstract]
- J Cell Mol Med. 2020 Mar;24(6):3328-3335. [Abstract]
- Cell Biol Int. 2026 Jan;50(1):e70099. [Abstract]
- Environ Toxicol. 2024 Mar;39(3):1429-1441. [Abstract]
- Research Square Preprint. 2020 Dec.
- Oxid Med Cell Longev. 2020 Apr 8:2020:5390482. [Abstract]
Customer Validation & Images
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Cell Proliferation/Viability Assay
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WB
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Cell Proliferation/Viability Assay
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WB
Biological Activity
Tanshinone IIA (12.5 μM) sulfonate sodium inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats. The suppressive effects of Tanshinone IIA sulfonate sodium on TRPC1 and TRPC6 expression in hypoxic PASMCs can be prevented by specific knockdown PKG or PPAR-γ. The suppressive effects of Tanshinone IIA sulfonate sodium on basal calcium concentration and SOCE in hypoxic PASMCs can be reversed by specific knockdown of PKG or PPAR-γ. PKG-PPAR-γ signaling axis participates in the suppressive effects of Tanshinone IIA sulfonate sodium on proliferation in hypoxic PASMCs. PPAR-γ agonist promotes the protective role of Tanshinone IIA sulfonate sodium on basal [Ca2+]i and SOCE in hypoxic PASMCs[2].
Tanshinone IIA sulfonate sodium inhibits the activity of CYP3A4 in a dose-dependent manner by the HLMs and CYP3A4 isoform. The KM and Vmax values of STS are 54.8 μM and 0.9 nmol/mg protein/min, respectively, for the HLMs and 7.5 μM and 6.8 nmol/nmol P450/min, respectively, for CYP3A4. CYP1A2, CYP2A6, CYP2C9, CYP2D6, CYP2E1, and CYP2C19 show minimal or no effects on the metabolism of STS[3].
Tanshinone IIA sulfonate sodium inhibits the activity of CYP3A4 in a dose-dependent manner in the HLMs and CYP3A4 isoform. Tanshinone IIA sulfonate sodium primarily inhibits the activities of CYP3A4 in vitro, and Tanshinone IIA sulfonate sodium has the potential to perpetrate drug-drug interactions with other CYP3A4 substrates[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Tanshinone IIA (30 mg/kg/day) sulfonate sodium prevention alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model[2].
Tanshinone IIA (20, 10, and 5 mg/kg, i.p.) sulfonate sodium effectively prevents peritoneal adhesion without affecting anastomotic healing in the rats. Compared with the adhesion model group, the Tanshinone IIA sulfonate sodium-treated groups show increased peritoneal lavage fluid tPA activity and tPA/PAI-1 ratio in the ischemic tissues with loared TGF-β1 and collagen I expressions in the ischemic tissues[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 69659-80-9
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Appearance Solid
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Molecular Weight 396.39
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Formula C19H17NaO6S
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Color Pink to red
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SMILES
O=S(C1=C(C)C(C(C(C2=C3C=CC4=C2CCCC4(C)C)=O)=O)=C3O1)(O[Na])=O
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Synonyms
Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (7)
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Journal Impact Factor
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Most Recent
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J Adv Res
Tanshinone IIA destabilizes SLC7A11 by regulating PIAS4-mediated SUMOylation of SLC7A11 through KDM1A, and promotes ferroptosis in breast cancer. [Abstract]2025 Mar:69:313-327. PMID: 38615741 -
Int Immunopharmacol
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis. [Abstract]2023 May:118:110111. PMID: 37028275
Tanshinone IIA sulfonate sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 May:118:110111. [Abstract]
Tanshinone IIA sulfonate sodium (STS; 10-50 μM; 24 h) induces significant cell death in BV2 cells.
Tanshinone IIA sulfonate sodium purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 May:118:110111. [Abstract]
Tanshinone IIA sulfonate sodium (STS; 5, 10 μM; 24 h) decreases the expression of iNOS in a dose-dependent manner in BV2 cells.
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J Cell Mol Med
Sodium tanshinone IIA sulfonate protects against Aβ-induced cell toxicity through regulating Aβ process. [Abstract]2020 Mar;24(6):3328-3335. PMID: 31989795
Tanshinone IIA sulfonate sodium purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Mar;24(6):3328-3335. [Abstract]
STS protects against Aβ-induced cell toxicity in SH-SY5Y cells. (A) MTS cell viability assay is performed in SH-SY5Y cells after exposure to different concentrations of Aβ (1.25, 2.5, 5, 10 and 20 µmol/L) for 24 h. (B) MTS cell viability of Aβ (10 µmol/L)-treated SY5Y cells after STS preprotection. STS-L: 1 µmol/L, STS-M: 10 µmol/L, STS-H: 100 µmol/L.
Tanshinone IIA sulfonate sodium purchased from MedChemExpress. Usage Cited in: J Cell Mol Med. 2020 Mar;24(6):3328-3335. [Abstract]
STS improves the protein expressions of Aβ degrading enzymes in Aβ-treated SH-SY5Y cells. NEP (A) and IDE (B) protein levels are detected by Western blotting in SH-SY5Y cells. STS-L: 1 µmol/L, STS-M: 10 µmol/L, STS-H: 100 µmol/L.
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Cell Biol Int
Sodium Tanshinone IIA Sulfonate Ameliorates Fibrosis of Skeletal Muscle Injury by Regulating Transforming Growth Factor-β1/Smad3 and Phosphoinositide 3-Kinase/protein Kinase B/Cyclooxygenase-2 Signaling Pathways. [Abstract]2026 Jan;50(1):e70099. PMID: 41165246 -
Environ Toxicol
Tanshinone IIA ameliorates cisplatin-induced toxicology and cisplatin resistance via regulating SLC7A11 expression. [Abstract]2024 Mar;39(3):1429-1441. PMID: 37987512 -
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Oxid Med Cell Longev
Tanshinone IIA Protects against Acute Pancreatitis in Mice by Inhibiting Oxidative Stress via the Nrf2/ROS Pathway. [Abstract]2020 Apr 8:2020:5390482. PMID: 32322336
Solvent & Solubility
DMSO : 62.5 mg/mL (157.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2 mg/mL (5.05 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (5.25 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * The compound is unstable in solutions, freshly prepared is recommended.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
Mice[1]
Male Kunming mice (KM, weighing 35-40 g) are maintained on standard laboratory conditions with free access to water and food. Mice are randomly divided into five groups: vehicle control group (CON, 0.9% saline, n=10), scopolamine group (SCOP, n=10), low dose Sodium Tanshinone IIA sulfonate group (Sodium Tanshinone IIA sulfonate L, SCOP 3 mg/kg + Sodium Tanshinone IIA sulfonate 10 mg/kg, n=10), high dose Sodium Tanshinone IIA sulfonate group (Sodium Tanshinone IIA sulfonate H, SCOP 3 mg/kg + Sodium Tanshinone IIA sulfonate 20 mg/kg, n=10), and Donepezil group (DON, SCOP 3 mg/kg + ARI 3 mg/kg, n=10). Mice are treated with saline, Sodium Tanshinone IIA sulfonate, and Donepezil, respectively, by gavage, once per day for two weeks. SCOP is injected from the eighth day for one week (intraperitoneally, IP). The SCOP is injected 0.5 h before the Morris water maze test.
Rats[2]
Male Sprague-Dawley rats (200-250 g) are randomly divided into four groups by the random number table: 1) normoxia control group, 2) normoxia + Sodium Tanshinone IIA sulfonate group, 3) hypoxia control group, and 4) hypoxia + Sodium Tanshinone IIA sulfonate group. Groups 1 and 2 are placed in normoxic condition and groups 3 and 4 in a hypoxic cabin with normal pressure, as previously reported, where the oxygen concentration is maintained at 10±1%, in a sustained hypoxic condition for 21 days. Groups 2 and 4, starting from the first day of hypoxia, are, respectively, intraperitoneally injected with 30 mg/kg tanshinone IIA sulfonate; meanwhile, groups 1 and 3 receive the same dose of saline.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (283 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;2016:9852536 [Content Brief]
[2]. Jiang Q, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. Am J Physiol Cell Physiol. 2016 Jul 1;311(1):C136-49. [Content Brief]
[3]. Ouyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11. [Content Brief]
[4]. Chen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2. [Content Brief]
[5]. Lin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O / DMSO | 1 mM | 2.5228 mL | 12.6138 mL | 25.2277 mL | 63.0692 mL |
| 5 mM | 0.5046 mL | 2.5228 mL | 5.0455 mL | 12.6138 mL | |
| DMSO | 10 mM | 0.2523 mL | 1.2614 mL | 2.5228 mL | 6.3069 mL |
| 15 mM | 0.1682 mL | 0.8409 mL | 1.6818 mL | 4.2046 mL | |
| 20 mM | 0.1261 mL | 0.6307 mL | 1.2614 mL | 3.1535 mL | |
| 25 mM | 0.1009 mL | 0.5046 mL | 1.0091 mL | 2.5228 mL | |
| 30 mM | 0.0841 mL | 0.4205 mL | 0.8409 mL | 2.1023 mL | |
| 40 mM | 0.0631 mL | 0.3153 mL | 0.6307 mL | 1.5767 mL | |
| 50 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2614 mL | |
| 60 mM | 0.0420 mL | 0.2102 mL | 0.4205 mL | 1.0512 mL | |
| 80 mM | 0.0315 mL | 0.1577 mL | 0.3153 mL | 0.7884 mL | |
| 100 mM | 0.0252 mL | 0.1261 mL | 0.2523 mL | 0.6307 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Tanshinone IIA sulfonate sodium Related Classifications
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