2. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
    Vitamin D Related/Nuclear Receptor
  3. Cannabinoid Receptor
    Fatty Acid Synthase (FASN)
    Androgen Receptor
  4. Leelamine hydrochloride

Leelamine hydrochloride 

Cat. No.: HY-110028 Purity: 98.10%
COA Handling Instructions

Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

For research use only. We do not sell to patients.

Leelamine hydrochloride Chemical Structure

Leelamine hydrochloride Chemical Structure

CAS No. : 16496-99-4

Size Price Stock Quantity
5 mg USD 210 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Leelamine hydrochloride is a tricyclic diterpene molecule that is extracted from the bark of pine trees[1]. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3].

IC50 & Target[2]

CB1

 

Molecular Weight

321.93

Appearance

Solid

Formula

C20H32ClN
CAS No.
SMILES

NC[[email protected]]1(C)CCC[[email protected]]2(C)C3=C(CC[[email protected]@]12[H])C=C(C(C)C)C=C3.Cl
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (77.66 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1063 mL 15.5313 mL 31.0627 mL
5 mM 0.6213 mL 3.1063 mL 6.2125 mL
10 mM 0.3106 mL 1.5531 mL 3.1063 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.77 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.77 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.77 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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C1   V1   C2   V2

Keywords:

Leelamine16496-99-4Cannabinoid ReceptorFatty Acid Synthase (FASN)Androgen ReceptorInhibitorinhibitorinhibit

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