trap1

Isoforms Recommended:	HSP70

By Targets:	AMPK (1) AP-1 (1) Apoptosis (1) Aquaporin (1) Autophagy (2) Drug Derivative (5) Environmental Pollutants (1) Glucocorticoid Receptor (1) HSP (11) Insecticide (4) Interleukin Related (1) Isotope-Labeled Compounds (2) MDM-2/p53 (1) Mitochondrial Metabolism (2) MyD88 (1) NF-κB (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2) Small Interfering RNA (siRNA) (4) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (2) Metabolic Disease (2)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10214

SNX-2112 3 Publications Verification PF-04928473	HSP Autophagy	Cancer
SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a K_d of 16 nM for Hsp90 and IC₅₀s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC₅₀s of 10 nM, 4.275 μM and 0.862 μM, respectively ^[1]. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with K_ds of 4 nM, 6 nM and 484 nM, respectively .

HY-169369

*TRAP-1* XJZ-06-462	MDM-2/p53 Apoptosis	Cancer
TRAP-1 (XJZ-06-462) is a non-covalent regulated induced proximity targeting chimera (RIPTAC) with JQ-1 carboxylic acid (HY-78695) as its target protein ligand. TRAP-1 forms a ternary complex with p53 ^Y220C and BRD4, potently activates p53 transcription, and inhibits the growth and proliferation of tumor cells. TRAP-1 upregulates p21 and other p53 target genes in pancreatic cell lines carrying p53 ^Y220C, and induces cellular senescence and apoptosis. TRAP-1 can be used in cancer research involving p53 ^Y220C-carrying tumors ^[1].

HY-10942

VER-82576 5 Publications Verification NVP-BEP800	HSP	Cancer
VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC₅₀ of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC₅₀s of 4.1 and 5.5 μM, respectively.

HY-W004292

1-Undecanol Undecyl alcohol	Environmental Pollutants Drug Derivative Insecticide	Infection
1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

HY-155063

TRAP1-IN-1	HSP Mitochondrial Metabolism	Cancer
TRAP1-IN-1 (compound 35) is a potent and selective inhibitor of *TRAP1，a mitochondrial isoform of Hsp90. TRAP1-IN-1* has >250-fold TRAP1 selectivity over Grp94，and disrupts TRAP1 tetramer stability，induces TRAP1 client protein degradation. TRAP1-IN-1 also inhibits mitochondrial complex I of oxidative phosphorylation OXPHOS，disrupts the mitochondrial membrane potential，and enhances glycolysis metabolism ^[1].

HY-N0237

Atractyloside A 3 Publications Verification	Toll-like Receptor (TLR) MyD88 NF-κB Mitochondrial Metabolism Interleukin Related Aquaporin	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Atractyloside A is an orally active inhibitor of the TLR4/MyD88/NF-κB signaling pathway and also an opener of the mitochondrial permeability transition pore (MPTP). Atractyloside A interferes with the activation of the TLR4/MyD88/NF-κB pathway, thereby inhibiting intestinal inflammatory responses. Atractyloside A reverses mucin synthesis impairment, improves intestinal barrier integrity, and restores homeostasis by altering the composition of the gut microbiota. Atractyloside A can be used in studies related to spleen deficiency diarrhea and myocardial injury ^[1] .

HY-115781

DN401 1 Publications Verification Panvotinib-401; Pan-401	HSP	Cancer
DN401 is a potent *TRAP1* inhibitor with an IC₅₀ of 79 nM. DN401 shows a weak inhibition of Hsp90 (IC₅₀ of 698 nM). DN401 inactivates mitochondrial TRAP1 and has potent anticancer activities ^[1].

HY-117395

PU-H54	HSP	Cancer
PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy ^[1]. PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-147696

SMTIN-T140	HSP AMPK Reactive Oxygen Species (ROS)	Cancer
SMTIN-T140 (compound 6a) is a potent *TRAP1* (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC₅₀ of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells ^[1].

HY-RS14984

TRAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRAP1 Human Pre-designed siRNA Set A TRAP1 Human Pre-designed siRNA Set A

HY-155064

TRAP1-IN-2	HSP	Metabolic Disease
TRAP1-IN-2 (compound 36) is a selective degrader of *TRAP1* downstream proteins without affecting Hsp90's cytoplasmic downstream proteins. TRAP1-IN-2 also inhibits OXPHOS and alters cellular glycolysis metabolism. TRAP1-IN-2 destabilizes TRAP1 tetramers and disrupts mitochondrial membrane potential.

HY-RS23969

Trap1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trap1 Rat Pre-designed siRNA Set A Trap1 Rat Pre-designed siRNA Set A

HY-RS17512

Trap1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Trap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Trap1 Mouse Pre-designed siRNA Set A Trap1 Mouse Pre-designed siRNA Set A

HY-W004292S

1-Undecanol-d23 Undecyl alcohol-d₂₃	Isotope-Labeled Compounds Drug Derivative Insecticide	Infection
1-Undecanol-d₂₃ (Undecyl alcohol-d₂₃) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

HY-144830

6BrCaQ	HSP	Cancer
6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates ^[1].

HY-144831

6BrCaQ-C10-TPP	HSP	Cancer
6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC₅₀=0.008-0.30 μM). 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance ^[1].

HY-182302

SMTIN-P01	Drug Derivative HSP	Cancer
SMTIN-P01 is a *TRAP1* inhibitor that is selective for cytosolic Hsp90 and accumulates in mitochondria. SMTIN-P01 binds to the ATP-binding site of *TRAP1* as an ATP mimic, thereby inhibiting ATPase and foldase activities. SMTIN-P01 induces mitochondrial membrane depolarization and proteolytic degradation in cancer cells. SMTIN-P01 exhibits significant cytotoxicity, but shows extremely low toxicity to primary mouse hepatocytes, and does not interfere with SIRT3-related functions or the levels of cytosolic Hsp90 substrates. SMTIN-P01 has important application value in cancer-related research ^[1] .

HY-RS14454

TGFBRAP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TGFBRAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TGFBRAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TGFBRAP1 Human Pre-designed siRNA Set A TGFBRAP1 Human Pre-designed siRNA Set A

HY-181014

Glucocorticoid receptor modulator 5	Glucocorticoid Receptor NF-κB AP-1	Inflammation/Immunology
Glucocorticoid receptor modulator 5 (Compound D8) is a selective, orally active Glucocorticoid receptor modulator. Glucocorticoid receptor modulator 5 shows extremely high transrepression activity (TR_NF-κB IC₅₀ = 0.0009 μM, TR_AP-1 IC₅₀ = 0.0005 μM). Glucocorticoid receptor modulator 5 exerts its anti-inflammatory activity by interacting directly with the Glucocorticoid receptor signaling pathway. Glucocorticoid receptor modulator 5 significantly alleviates dermatitis and autoimmune hepatitis ^[1].

HY-W004292S1

1-Undecanol-d4 Undecyl alcohol-d₄	Isotope-Labeled Compounds Drug Derivative Insecticide	Infection
1-Undecanol-d₄ (Undecyl alcohol-d₄) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

HY-W004292R

1-Undecanol (Standard) Undecyl alcohol (Standard)	Drug Derivative Reference Standards Insecticide	Infection
1-Undecanol (Standard) (Undecyl alcohol (Standard)) is an analytical reference standard for 1-Undecanol (HY-W004292). This product is used for research and analytical applications. 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

HY-10214R

SNX-2112 (Standard) PF-04928473 (Standard)	Reference Standards HSP Autophagy	Cancer
SNX-2112 (Standard) is the analytical standard of SNX-2112 (HY-10214). This product is intended for research and analytical applications. SNX-2112 (PF 04928473) is an orally active Hsp90 inhibitor, with a K_d of 16 nM for Hsp90 and IC₅₀s of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC₅₀s of 10 nM, 4.275 μM and 0.862 μM, respectively ^[1]. SNX-2112 (PF 04928473) binds Hsp90 isoforms Hsp90α, Hsp90β and Hsp90b1/Grp94 with Kds of 4 nM, 6 nM and 484 nM, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W004292

1-Undecanol Undecyl alcohol	Structural Classification Natural Products Microorganisms other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Environmental Pollutants Drug Derivative Insecticide
1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

HY-N0237

Atractyloside A 3 Publications Verification	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Other Diseases Plants Compositae Disease Research Fields Source Classification Erythrina sigmoidea Hua	Toll-like Receptor (TLR) MyD88 NF-κB Mitochondrial Metabolism Interleukin Related Aquaporin
Atractyloside A is an orally active inhibitor of the TLR4/MyD88/NF-κB signaling pathway and also an opener of the mitochondrial permeability transition pore (MPTP). Atractyloside A interferes with the activation of the TLR4/MyD88/NF-κB pathway, thereby inhibiting intestinal inflammatory responses. Atractyloside A reverses mucin synthesis impairment, improves intestinal barrier integrity, and restores homeostasis by altering the composition of the gut microbiota. Atractyloside A can be used in studies related to spleen deficiency diarrhea and myocardial injury ^[1] .

HY-W004292R

1-Undecanol (Standard) Undecyl alcohol (Standard)	Structural Classification Natural Products Microorganisms other families Plants Source Classification	Drug Derivative Reference Standards Insecticide
1-Undecanol (Standard) (Undecyl alcohol (Standard)) is an analytical reference standard for 1-Undecanol (HY-W004292). This product is used for research and analytical applications. 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

Species:	Human (2) Rat (3)
Tag:	His (1) Tag Free (2) GST (1)
Source:	E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71537

	TRAP1 Protein, Human (GST) Heat shock protein 75kDa; Heat shock protein 75kDa, mitochondrial; HSP 75; HSP75; HSP90L; mitochondrial; TNF receptor associated protein 1; TNFR-associated protein 1; trap-1; trap1; trap1_HUMAN; Tumor necrosis factor type 1 receptor-associated protein	Human	E. coli
	As a chaperone with ATPase activity, TRAP1 protein plays a crucial role in protecting mitochondrial function and polarization, especially downstream of PINK1 and mitochondrial complex I. TRAP1 acts as a negative regulator of mitochondrial respiration, affecting the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1 Protein, Human (GST) is the recombinant human-derived TRAP1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P703409

	TRAP1 Protein, Rat Hsp75; Hspc5	Rat	E. coli
	TRAP1 Protein, Rat is the recombinant rat-derived TRAP1, expressed by E. coli , with tag Free labeled tag. ,

HY-P703408

	TRAP1 Protein, Rat (His) Hsp75; Hspc5	Rat;Human	E. coli
	TRAP1 Protein, Rat (His) is the recombinant Rat-derived TRAP1, expressed by E. coli , with His labeled tag. ,

HY-P703407

	TRAP1 Protein, Rat (646a.a) Hsp75; Hspc5	Rat	E. coli
	TRAP1 Protein, Rat is the recombinant rat-derived TRAP1, expressed by E. coli , with tag Free labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-W004292S

1-Undecanol-d23
1-Undecanol-d₂₃ (Undecyl alcohol-d₂₃) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

HY-W004292S1

1-Undecanol-d4
1-Undecanol-d₄ (Undecyl alcohol-d₄) is the deuterium labeled 1-Undecanol (HY-W004292). 1-Undecanol (Undecyl alcohol) is the main product generated from the degradation of 2-tridecanone by Pseudomonas bacteria isolated from the soil. 1-Undecanol can enhance the attraction of Grapholita molesta to sex pheromone traps .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82880

	Hsp75 Antibody (YA2625) HSP75; HSP90L; trap1	WB, IHC-P, ICC/IF	Human
	Hsp75 Antibody (YA2625) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hsp75.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-117395

PU-H54		Alkynes
PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy ^[1]. PU-H54 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name		Classification

HY-RS14984

TRAP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TRAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TRAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23969

Trap1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Trap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Trap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17512

Trap1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Trap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS14454

TGFBRAP1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TGFBRAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TGFBRAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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