TRAP1 Protein, Rat (His)
TRAP1 Protein, Rat (His) is the recombinant Rat-derived TRAP1, expressed by E. coli , with His labeled tag. ,
- Species: Rat; Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
TRAP1 Protein, Rat (His) is the recombinant Rat-derived TRAP1, expressed by E. coli , with His labeled tag. ,
TRAP1 (TNF receptor-associated protein 1) serves as a chaperone with ATPase activity and is integral in preserving mitochondrial function and polarization, functioning downstream of PINK1 and mitochondrial complex I. It acts as a negative regulator of mitochondrial respiration, dynamically influencing the balance between oxidative phosphorylation and aerobic glycolysis. TRAP1's impact on mitochondrial respiration is likely mediated through the modulation of mitochondrial SRC and inhibition of SDHA. Furthermore, TRAP1 interacts with diverse cellular components, including binding to the intracellular domain of the tumor necrosis factor type 1 receptor, forming complexes with RB1, and engaging with SRC and SDHA. These interactions underscore the multifaceted nature of TRAP1's involvement in cellular processes (
Technical Parameters
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Species Rat; Human
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Source E. coli
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Tag His
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Accession
Q5XHZ0 (S61-H706)
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Gene ID287069
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Protein Length
Full Length of Mature Protein
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Synonyms
TRAP1; TNF Receptor-Associated Protein 1; TNF Receptor Associated Protein 1; HSP 75; HSP75; TRAP-1; Tumor Necrosis Factor Type 1 Receptor-Associated Protein; CDNA FLJ33058 Fis, Clone TRACH1000181, Highly Similar To Heat Shock Protein 75 KDa, Mitochondrial
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AA Sequence
STQAAEDKKEEALHSIISNTEAVQGSVSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKRVCEGQVLPEMEIHLQTDAEKGTITIQDTGIGMTKEELVSNLGTIARSGSKAFLEALQHQAETSSRIIGQFGVGFYSAFMVADKVEVYSRPAAPESPGYQWLSDGSGVFEIAEASGVRPGTKIIIHLKSDCKDFANESRVQDVVTKYSNFVSFPLYLNGRRINTLQAIWMMDPKDISEFQHEEFYRYIAQAYDKPRFILHYKTDAPLNIRSIFYVPEMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFVRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTTAEQDIKEDIAKLLRYESSALPAGQLTSLSDYASRMQAGTRNIYYLCAPNRHLAEHSPYYEAMKQKQTEVLFCYEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDTSPAGERLSEKETEELMAWMRNALGSRVTNVKVTFRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHTLIKKLNQLREREPELAQLLVDQIYENAMIAAGLVDDPRAMVGRLNDLLVKALERH
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Predicted Molecular Mass
75.7 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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