1. Epigenetics
    PI3K/Akt/mTOR
    Protein Tyrosine Kinase/RTK
  2. AMPK
    ROS
  3. SMTIN-T140

SMTIN-T140 

Cat. No.: HY-147696
Handling Instructions

SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells.

For research use only. We do not sell to patients.

SMTIN-T140 Chemical Structure

SMTIN-T140 Chemical Structure

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Description

SMTIN-T140 (compound 6a) is a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor, with an IC50 of 1.646 μM. SMTIN-T140 shows anticancer activity. SMTIN-T140 leads to mitochondrial dysfunction, increases mitochondrial ROS production and activates AMPK. SMTIN-T140 potently suppressed tumor growth without any noticeable in vivo toxicity in a mouse model xenografted with PC3 prostate cancer cells[1].

IC50 & Target

IC50: 1.646 ± 0.024 μM (TRAP1)[1]

Molecular Weight

718.02

Formula

C36H34BrClFN5OP+

SMILES

NC1=NC(Cl)=C2C(N(C(N2CCCCCC[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5)=O)CC6=C(C=C(C=C6)Br)F)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SMTIN-T140
Cat. No.:
HY-147696
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