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Isoforms Recommended: USP1
Results for "

usp1

" in MedChemExpress (MCE) Product Catalog:

31

Inhibitors & Agonists

2

Natural
Products

1

Recombinant Proteins

1

Isotope-Labeled Compounds

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145471
    KSQ-4279
    1 Publications Verification

    usp1-IN-1

    		 Deubiquitinase PARP Cancer
    KSQ-4279 (USP1-IN-1) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 is promising for research of cancers [1].
    KSQ-4279
  • HY-N6979
    Crustecdysone
    10+ Cited Publications

    20-Hydroxyecdysone

    		 Caspase Autophagy Endogenous Metabolite Cardiovascular Disease
    Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .
    Crustecdysone
  • HY-17543
    ML-323
    Maximum Cited Publications
    17 Publications Verification

    		 Deubiquitinase Cancer
    ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM.
    ML-323
  • HY-160700
    TNG348

    		Deubiquitinase JNK Cancer
    TNG348 is an orally available allosteric inhibitor of the ubiquitin-specific protease USP1. TNG348 specifically and efficiently inhibits the activity of USP1, inhibiting its deubiquitination of proliferative PCNA and FANCD2, thereby disrupting the DNA repair process. TNG348 has inhibitory activity against breast and ovarian cancers carrying BRCA1/2 mutations and other homologous recombination defects (HRD) [1] .
    TNG348
  • HY-148184
    USP1-IN-3

    		Deubiquitinase Cancer
    USP1-IN-3 is a selective USPI inhibitor. USP1-IN-3 inhibits USPI-UAFI with an IC50 value of ＜30 nM. USP1-IN-3 can be used for the research of cancer [1].
    USP1-IN-3
  • HY-80012
    SJB3-019A
    10+ Cited Publications

    		 Deubiquitinase Cancer
    SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.
    SJB3-019A
  • HY-148099
    USP1-IN-2

    		Deubiquitinase Cancer
    USP1-IN-2 (Compound I-193) is a potent ubiquitin-specific protease 1 (USP1) inhibitor with an IC50 of less than about 50 nM. USP1-IN-2 can be used for the study of cancers such as osteosarcoma [1].
    USP1-IN-2
  • HY-153365
    I-138

    		Deubiquitinase Cancer
    I-138 is an orally active, reversible inhibitor of USP1-UAF1 (IC50: 4.1 nM; Ki: 5.4 nM), structurally related to ML323 (HY-17543). I-138 induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells [1].
    I-138
  • HY-15757
    SJB2-043
    4 Publications Verification

    		 Deubiquitinase Cancer
    SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM.
    SJB2-043
  • HY-12988
    C527
    1 Publications Verification

    		 Deubiquitinase Cancer
    C527 is a is a pan DUB enzyme inhibitor, with a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
    C527
  • HY-153731
    USP1-IN-4

    		Deubiquitinase Cancer
    USP1-IN-4 (compound 10) is an effective USP1 inhibitor with an IC50 value of 2.44 nM. USP1-IN-4 has anticancer activity and synergistic activity with various anticancer drugs [1].
    USP1-IN-4
  • HY-176704
    USP1-IN-13

    		Deubiquitinase Cancer
    USP1-IN-13 (Compound 2) is a potent and orally active USP1 inhibitor with an IC50 value of 1.02 nM. USP1-IN-13 can be used for the study of breast cancer [1].
    USP1-IN-13
  • HY-145471A
    KSQ-4279 gentisate
    1 Publications Verification

    		 Deubiquitinase PARP Cancer
    KSQ-4279 (gentisate) (Compound Formula I) is a potent USP1 inhibitor and a selective PARP1 inhibitor. KSQ-4279 (gentisate) is promising for research of cancers [1].
    KSQ-4279 gentisate
  • HY-179292
    USP1-IN-14

    		Deubiquitinase Inflammation/Immunology Cancer
    USP1-IN-14 (compound 27) is a ubiquitin-specific protease 1 (USP1) inhibitor with an IC50 of 0.001 µM. USP1-IN-14 can be used for USP1-related cancers, autoimmune and inflammatory disorders research [1].
    USP1-IN-14
  • HY-RS15520
    USP1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    USP1 Human Pre-designed siRNA Set A contains three designed siRNAs for USP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    USP1 Human Pre-designed siRNA Set A
    USP1 Human Pre-designed siRNA Set A
  • HY-172824
    MS7131

    		Deubiquitinase Cancer
    MS7131 is a USP1-recruiting DUBTACs. MS7131 effectively reduces histone H3 lysine 27 trimethylation and significantly suppresses the proliferation and clonogenicity of cancer cells [1].
    MS7131
  • HY-161878
    USP1-IN-10

    		Deubiquitinase Cancer
    USP1-IN-10 (compound 2) is a potent tricyclic USP1 inhibitor with an IC50 of 7.6 nM. USP1-IN-10 inhibits MDA-MB-436 viability (IC50=21.58 nM). USP1-IN-10 has the potential for cancers research [1].
    USP1-IN-10
  • HY-162633
    USP1-IN-9

    		Deubiquitinase Cancer
    USP1-IN-9 (Compound 1m) is reversible and noncompetitive ubiquitin-specific proteases (USP1) inhibitors with an IC50 of 8.8 nM, which is designed and synthesized to pyrido[2,3-d]pyrimidin-7(8H)-one derivative based on the disclosed structure of ML323(HY-17543) and KSQ-4279(HY-145471). USP1-IN-9 displays excellent USP1/UAF inhibition and exhibits strong antiproliferation effect in breast cancer cells. USP1-IN-9 can generate enhanced cell killing with PARP inhibitor olaparib(HY-10162) in olaparib-resistant MDA-MB-436/OP cells, which is promising for research in the field of cancer [1].
    USP1-IN-9
  • HY-RS16567
    Usp1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Usp1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Usp1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Usp1 Mouse Pre-designed siRNA Set A
    Usp1 Mouse Pre-designed siRNA Set A
  • HY-RS23000
    Usp1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Usp1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Usp1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Usp1 Rat Pre-designed siRNA Set A
    Usp1 Rat Pre-designed siRNA Set A
  • HY-156525
    USP1-IN-6

    		Deubiquitinase Cancer
    USP1-IN-6 (compound 11) is a USP1 inhibitor (IC50<50 nM). USP1-IN-5 also inhibits MDA-MB-436 cells with IC50 <50 nM [1].
    USP1-IN-6
  • HY-156524
    USP1-IN-5

    		Deubiquitinase Cancer
    USP1-IN-5 (compound 10) is a USP1 inhibitor (IC50<50 nM). USP1-IN-5 also inhibits MDA-MB-436 cells with IC50 <50 nM [1].
    USP1-IN-5
  • HY-161446
    USP1-IN-7

    		Deubiquitinase Cancer
    USP1-IN-7 (Compound 3) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-7 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM [1].
    USP1-IN-7
  • HY-161447
    USP1-IN-8

    		Deubiquitinase Cancer
    USP1-IN-8 (Compound 16) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-8 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM [1].
    USP1-IN-8
  • HY-176703
    USP1-IN-12

    		Deubiquitinase Cancer
    USP1-IN-12 (compound 4) is a potent and orally activeUSP1 inhibitor with an IC50 value of 0.00366 µM. USP1-IN-12 inhibits cell clone formation [1].
    USP1-IN-12
  • HY-170921
    USP1-IN-11

    		Deubiquitinase Cancer
    USP1-IN-11 (compound 38-P2) is a selective, reversible, and noncompetitive USP1 (Ubiquitin-specific protease 1) inhibitor. USP1-IN-11 activates the DDR (DNA damage repair) pathway, induces cell cycle arrest and cell Apoptosis, and inhibits cell survival. USP1-IN-11 enhances the sensitivity of Olaparib (HY-10162)-resistant cells to Olaparib (HY-10162) and shows a synergetic effect with Andrographolide (HY-N0191) in BRCA-proficient cancer cells. USP1-IN-11 displays significant, dose-dependent antitumor efficacy in the MDA-MB-436 xenograft model [1].
    USP1-IN-11
  • HY-180216
    USP1-IN-15

    		Deubiquitinase Cancer
    USP1-IN-15 is an orally active and selective USP1 inhibitor with an IC50 of 12.3 nM. USP1-IN-15 has a high specificity for USP1 with negligible inhibition against all off-target DUBs. USP1-IN-15 suppresses colony formation, induces S-phase arrest, and stabilizes ubiquitinated PCNA. USP1-IN-15 also shows synergistic antiproliferative activity. USP1-IN-15 achieves significant tumor growth inhibition in vivo. USP1-IN-15 can be used for BRCA-mutated breast cancer [1].
    USP1-IN-15
  • HY-181702
    USP1-IN-16

    		Deubiquitinase Cancer
    USP1-IN-16 is a USP1 inhibitor with an USP1-UAF1 IC50 value of 0.002 μM. USP1-IN-16 can be used in the research of USP1-related malignancies [1].
    USP1-IN-16
  • HY-183363
    USP1-IN-17

    		Deubiquitinase Cancer
    USP1-IN-17 is an orally active USP1/UAF1 complex inhibitor. USP1-IN-17 exhibits potent anti-proliferative activity against BRCA1-mutant human breast cancer MDA-MB-436 cells, with an IC50 value of 8.1 nM. USP1-IN-17 binds to USP1 to stabilize the enzyme conformation, impairs deubiquitination function, elevates the monoubiquitination level of PCNA, inhibits cancer cell proliferation, and induces DNA damage accumulation. USP1-IN-17 can be used for the research of BRCA1-mutated cancers [1].
    USP1-IN-17
  • HY-183581
    USP1-IN-18

    		Deubiquitinase DNA/RNA Synthesis Cancer
    USP1-IN-18 is an orally active USP1 inhibitor with a human IC50 of 17.0 nM. USP1-IN-18 inhibits USP1-UAF1 deubiquitinase activity and drives ubiquitinated PCNA accumulation. USP1-IN-18 induces DNA damage, replication stress, and G2-M phase cell cycle arrest. USP1-IN-18 can be used for the research of triple-negative breast cancer [1].
    USP1-IN-18
  • HY-N6979R
    Crustecdysone (Standard)

    20-Hydroxyecdysone (Standard)

    		 Reference Standards Caspase Autophagy Endogenous Metabolite Cardiovascular Disease
    Crustecdysone (Standard) is the analytical standard of Crustecdysone. This product is intended for research and analytical applications. Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP . Crustecdysone exhibits regulatory or protective roles in the cardiovascular system . Crustecdysone is an active metabolite of Ecdysone (HY-N0179) .
    Crustecdysone (Standard)

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