1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. SJB3-019A

SJB3-019A 

Cat. No.: HY-80012 Purity: >99.00%
Handling Instructions

SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.

For research use only. We do not sell to patients.

SJB3-019A Chemical Structure

SJB3-019A Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 315 In-stock
Estimated Time of Arrival: December 31
5 mg USD 286 In-stock
Estimated Time of Arrival: December 31
10 mg USD 432 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1026 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1596 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC50 of 0.0781 μM.

IC50 & Target

IC50: 78.1 nM (ID1)

In Vitro

SJB3-019A (IC50=0.0781 μM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (36.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6199 mL 18.0995 mL 36.1991 mL
5 mM 0.7240 mL 3.6199 mL 7.2398 mL
10 mM 0.3620 mL 1.8100 mL 3.6199 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1 mg/mL (3.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

276.25

Formula

C₁₆H₈N₂O₃

SMILES

O=C1C2=C(OC(C3=CC=CN=C3)=N2)C(C4=CC=CC=C41)=O

Shipping

Room temperature in continental US; may vary elsewhere

Purity: >99.00%

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
SJB3-019A
Cat. No.:
HY-80012
Quantity:

SJB3-019A

Cat. No.: HY-80012