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Cat. No.: HY-156524

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USP1-IN-5

USP1-IN-5 (compound 10) is a USP1 inhibitor (IC₅₀<50 nM). USP1-IN-5 also inhibits MDA-MB-436 cells with IC₅₀ <50 nM.

For research use only. We do not sell to patients.

CAS No.: 2925547-94-8
Formula: C₂₇H₂₃F₃N₈O
Molecular Weight:532.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

USP1-IN-5 Chemical Structure

CAS No.: 2925547-94-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

USP1-IN-5 (compound 10) is a USP1 inhibitor (IC₅₀<50 nM). USP1-IN-5 also inhibits MDA-MB-436 cells with IC₅₀ <50 nM^[1].

IC₅₀ & Target

IC50: <50 nM (USP1)^[1]

All Deubiquitinase Isoforms :

Chemical Information

CAS No. 2925547-94-8
Molecular Weight 532.52
Formula C₂₇H₂₃F₃N₈O
SMILES

FC(F)(C1=CN(C)C(C23C4C5C2C6C3C4C65CN7N=CC8=C7N=C(C9=C(C%10CC%10)N=CN=C9OC)N=C8)=N1)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wu J, et al. Preparation of heteroaromatic compounds as small molecule inhibitors of ubiquitin specific protease 1 (USP1) and uses thereof. World Intellectual Property Organization, WO2023083285 A1. 2023-05-19.

Calculators

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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