USP1-IN-13
USP1-IN-13 (Compound 2) is a potent and orally active USP1 inhibitor with an IC50 value of 1.02 nM. USP1-IN-13 can be used for the study of breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 2974433-50-4
- Formula: C30H33F4N7O
- Molecular Weight:583.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
USP1 1.02 nM (IC50) |
In Vitro
USP1-IN-13 (Compound 2) (14 d) inhibits the colony-forming ability of MDA-MB-436 cells, with its IC50 value being 31.34 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Parmacokinetics
| Species | Dose | Route | Cmax | AUC0-t |
|---|---|---|---|---|
| Mice[1] | 10 mg/kg | i.g. | 1432 ng/mL | 9888 ng·h/mL |
Chemical Information
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CAS No. 2974433-50-4
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Molecular Weight 583.62
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Formula C30H33F4N7O
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SMILES
COC1=C(C(C2CC2)=NC=N1)C3=C(C4=C(C=NN4CC56CCC(CC5)(CC6)C7=NC(C(F)(F)F)=CN7C(C)C)C=N3)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
USP1-IN-13 Related Classifications
HY-176704 Related Classifications
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