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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
variation
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "variation" in MCE Product Catalog:
6
6 Cited Publications
Synonyms: Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium
Cat. No.: HY-W440896
DSPE-PEG2000-SH is an amphiphilic thiol-functionalized DSPE-PEG molecule. DSPE-PEG2000-SH inserts into extracellular vesicle (EV) bilayer membranes via hydrophobic interactions, displaying surface thiol groups to form EV-SH crosslinkers.DSPE-PEG2000-SH enables crosslinking of EV-SH with 8-arm PEG-norbornene via thiol-ene photochemistry to construct hydrogels, with hydrogel mechanical properties tunable via PEG segment molecular weight variation.DSPE-PEG2000-SH can be used to encapsulate agents for drug delivery system, such as mRNA vaccine .
Cat. No.: HY-W042214
CAS No.: 19395-41-6
Synonyms: Ritalinate
Research Areas:
Ritalinic acid (Ritalinate) is a metabolite of Methylphenidate. Ritalinic acid has no biological activity or only extremely low biological activity. The concentration of Ritalinic acid detected in university campus sewage shows a gradual upward trend in the first semester, while no obvious periodic variation pattern related to academic stress is observed in the second semester. Ritalinic acid can be used in studies related to attention deficit disorder, narcolepsy, depression and attention deficit hyperactivity disorder .
Cat. No.: HY-U00050
CAS No.: 47132-16-1
Synonyms: E-10-OH-NT
Target:
Research Areas:
(E)-10-Hydroxynortriptyline (E-10-OH-NT) is a blood-brain barrier-permeable norepinephrine uptake inhibitor. (E)-10-Hydroxynortriptyline effectively promotes central norepinephrine neuronal transmission, with little interindividual variation in in vivo potency. (E)-10-Hydroxynortriptyline has low affinity for muscarinic receptors, exhibits only extremely weak anticholinergic activity, and does not inhibit salivary secretion. (E)-10-Hydroxynortriptyline can be used in studies related to depression .
Target:
Research Areas:
Synonyms: FAGLA
FA-Gly-Leu-NH2 (FAGLA) is a dipeptide substrate for proteases that can be hydrolyzed by thermophilic proteases and neutral proteases, showing pH-dependent variations in kcat/Km .
Synonyms: Trimethylglycine (Standard); carboxy-N,N,N-trimethylmethanaminium (Standard)
Cat. No.: HY-D1556
CAS No.: 384832-91-1
Synonyms: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-(carboxyfluorescein) ammonium
Cat. No.: HY-N17260
CAS No.: 21391-98-0
Category:
Natural Products Ketones, Aldehydes, Acids Eucalyptus camaldulensis Dehnh. Myrtaceae Plants
Target:
Cat. No.: HY-B0710S
CAS No.: 309762-22-9
Synonyms: Trimethylglycine-13C3; Carboxy-N,N,N-trimethylmethanaminium-13C3
Category:
Alkaloids Pyrrole Alkaloids Other Diseases Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields
Target:
Cat. No.: HY-W781921
CAS No.: 1006592-47-7
Target:
Research Areas:
BP Fluor 488 Alkyne is a popular labeling dye used in Click Chemistry reactions. It will react with the azide group in antibody, proteins, peptides, amino-modified oligos, and other target molecules. The dye has an excitation peak at 499 nm and an emission peak at 520 nm. The conjugates are widely used in microscopy, flow cytometry, and other applications. BP Fluor 488 is a pure 5-sulfonated rhodamine molecule and it eliminates the lot-to-lot variation caused by two isomers ratio differences.
Cat. No.: HY-W800680
CAS No.: 2423960-92-1
Cat. No.: HY-W713313
CAS No.: 24973-29-3
Synonyms: 3,5-Dimethoxyamphetamine hydrochloride
Target:
Research Areas:
3,5-DMA (3,5-Dimethoxyamphetamine) hydrochloride is an alkylphenylamine compound primarily catalyzed by NAT2. The metabolic rate of 3,5-DMA hydrochloride is closely related to the NAT2 acetylator genotype variation. 3,5-DMA is useful for studying the role of NAT2 acetylator genotype variation in the metabolism of alkylphenylamine carcinogens .
Cat. No.: HY-153995A
CAS No.: 642-98-8
Research Areas:
D-Ribonic acid is a metabolite of D-Ribose (HY-113375). Ribonic acid is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid may participate in the mitochondrial energy production process .
Cat. No.: HY-130280
CAS No.: 1643593-28-5
Ianthelliformisamine A TFA is an antibiotic enhancer with activity against resistant Gram-negative bacteria. Ianthelliformisamine A TFA exhibits bactericidal activity against Staphylococcus aureus with an IC50 value of 3.8 μM (minimum inhibitory concentration = 25 μM). The biological activity of Ianthelliformisamine A TFA is derived from the structural variation of its synthetic derivatives and its coupling reaction with different amino ester derivatives .
Cat. No.: HY-121856
CAS No.: 36740-73-5
Target:
Research Areas:
Flumizole, a derivative of substituted 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles, was synthesized and evaluated for its immunoregulatory and anti-inflammatory properties in animal models such as rat adjuvant-induced arthritis and mouse oxazolone-induced contact sensitivity assays. This compound class combines structural elements from flumizole and levamisole, aiming to enhance therapeutic efficacy. Symmetrically substituted 5,6-diaryl compounds with specific alkyl heteroatom or halogen substitutions showed optimal potency in the arthritis model. However, variations in activity were less consistent in the contact sensitivity assay. Flumizole and related compounds demonstrate potential as dual-action agents, targeting inflammation and immune modulation, offering promise for therapeutic development in immune-related disorders .
Cat. No.: HY-168384
CAS No.: 875158-73-9
Target:
Research Areas:
M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs). At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases .
Cat. No.: HY-153995B
CAS No.: 90801-23-3
Research Areas:
D-Ribonic acid ammonium is a metabolite of D-Ribose (HY-113375). Ribonic acid ammonium is associated with genetic variations in ENOSF1 and NUBPL. Ribonic acid ammonium may participate in the mitochondrial energy production process .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
