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Isoforms Recommended: Vps34
Results for "

vps34

" in MedChemExpress (MCE) Product Catalog:

19

Inhibitors & Agonists

1

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-12481
    SAR405
    Maximum Cited Publications
    35 Publications Verification

    		 PI3K Autophagy Cancer
    SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity .
    SAR405
  • HY-12795
    Vps34-IN-1
    10+ Cited Publications

    		 PI3K Autophagy Cancer
    Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC50 of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy .
    Vps34-IN-1
  • HY-145752
    HaloPROTAC-E
    1 Publications Verification

    		 PROTACs SGK Autophagy Cancer
    HaloPROTAC-E is a potent Halo PROTAC degrader that reversibly induces degradation of two Halo-tagged endoplasmic reticulum-localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM. HaloPROTAC-E significantly and selectively induces degradation of endogenous VPS34 complexes (VPS34, VPS15, Beclin1, and ATG14) labeled with Halo and inhibits autophagy.
    HaloPROTAC-E
  • HY-12794
    Vps34-PIK-III
    10+ Cited Publications

    		 PI3K Autophagy Neurological Disease Cancer
    Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs) .
    Vps34-PIK-III
  • HY-101920
    Autophinib
    10+ Cited Publications

    		 Autophagy PI3K Neurological Disease Cancer
    Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 .
    Autophinib
  • HY-123058
    Vps34-IN-4

    		PI3K Autophagy Cancer
    Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components .
    Vps34-IN-4
  • HY-12473
    Vps34-IN-2
    5+ Cited Publications

    		 PI3K SARS-CoV Cancer
    Vps34-IN-2 is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively . Vps34-IN-2 shows antiviral activity against SARS-CoV-2 (IC50 of 3.1 μM), HCoV-229E (IC50 of 0.7 μM) and HCoV-OC43 .
    Vps34-IN-2
  • HY-136265
    BC-LI-0186
    1 Publications Verification

    		 Aminoacyl-tRNA Synthetase Cancer
    BC-LI-0186 is a potent and selective inhibitor of Leucyl-tRNA synthetase (LRS; LeuRS) and Ras-related GTP-binding protein D (RagD) interaction (IC50=46.11 nM). BC-LI-0186 competitively binds to the RagD interacting site of LRS (Kd=42.1 nM) and has on effects on LRS-Vps34, LRS-EPRS, RagB-RagD association, mTORC1 complex formation or the activities of 12 kinases. BC-LI-0186 can effectively suppress the activity of cancer-associated?MTOR?mutants and the growth of rapamycin-resistant cancer cells.?BC-LI-0186 is a promising agent for lung cancer research .
    BC-LI-0186
  • HY-122891
    SB02024
    1 Publications Verification

    		 PI3K CXCR STAT Cancer
    SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via STAT1/IRF7. SB02024 shows anticancer activity .
    SB02024
  • HY-156237
    Beclin1-ATG14L interaction inhibitor 1
    2 Publications Verification

    		 Autophagy Others
    Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport .
    Beclin1-ATG14L interaction inhibitor 1
  • HY-12481A
    SAR405 R enantiomer

    		PI3K Cancer
    SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor.
    SAR405 R enantiomer
  • HY-141895
    Vps34-IN-3

    		PI3K Cancer
    Vps34-IN-3 is a potent, selective, and orally bioavailable VPS34 kinase inhibitor.
    Vps34-IN-3
  • HY-112608
    CHMFL-PI3KD-317

    		PI3K Cancer
    CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3Kα (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3Kγ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells .
    CHMFL-PI3KD-317
  • HY-122891A
    (2S)-SB02024

    		PI3K Cancer
    (2S)-SB02024 (SB02877), the S-enantiomer of SB02024 (HY-122891), is a Vps34 inhibitor .
    (2S)-SB02024
  • HY-182378
    Vps34-IN-5

    		Cancer
    Vps34-IN-5 is an orally active VPS34 inhibitor, 98% target inhibition, and an IC50 categorized as B. Vps34-IN-5 induces additive or synergistic anti-proliferative activity with EGFR inhibitors in cancer cells. Vps34-IN-5 is administered orally alone or with Erlotinib (HY-50896) in mouse xenograft models. Vps34-IN-5 can be used for the research of non-small cell lung cancer .
    Vps34-IN-5
  • HY-101920R
    Autophinib (Standard)

    		Reference Standards Autophagy PI3K Neurological Disease Cancer
    Autophinib (Standard) is the analytical standard of Autophinib (HY-101920). This product is intended for research and analytical applications. Autophinib is a potent, selective autophagy inhibitor with IC50s of 90 nM and 40 nM for starvation- and Rapamycin-induced autophagy, respectively. Autophinib is also an ATP competitive Vacuolar Protein Sorting 34 (VPS34) inhibitor with an IC50 of 19 nM. Autophinib inhibits autophagy induced by starvation or Rapamycin by targeting VPS34 .
    Autophinib (Standard)
  • HY-RS10520
    PIK3C3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PIK3C3 Human Pre-designed siRNA Set A contains three designed siRNAs for PIK3C3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PIK3C3 Human Pre-designed siRNA Set A
    PIK3C3 Human Pre-designed siRNA Set A
  • HY-RS10521
    Pik3c3 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Pik3c3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pik3c3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Pik3c3 Mouse Pre-designed siRNA Set A
    Pik3c3 Mouse Pre-designed siRNA Set A
  • HY-181815
    SBP-5147

    		ULK Beclin1 Autophagy MHC Caspase Apoptosis Cancer
    SBP-5147 is an orally active ULK1/ULK2 inhibitor, with an IC50 of 2 nM against ULK1 and an IC50 of 53 nM against ULK2. SBP-5147 inhibits the phosphorylation of Beclin-1 and Vps34, reduces autophagy flux, downregulates the expression of ATG13 and ATG101, upregulates the expression of MHC-I, induces caspase-dependent apoptosis, and decreases the viability of non-small cell lung cancer cells. SBP-5147 is applicable to research related to non-small cell lung cancer [1] .
    SBP-5147

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