2. GPCR/G Protein
  3. P2Y Receptor
  4. Selatogrel

Selatogrel  (Synonyms: ACT-246475)

製品番号: HY-109122 純度: 99.75%
COA 取扱説明書 Technical Support

Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy.

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Selatogrel

Selatogrel 構造式

CAS 番号 : 1159500-34-1

容量 価格（税別） 在庫状況 数量
5 mg $310 在庫あり
10 mg $510 在庫あり
25 mg $1020 在庫あり
50 mg $1650 在庫あり
100 mg $2640 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Other Forms of Selatogrel:

Selatogrel 関連抗体

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P2Y Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y11 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

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製品説明

Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy[1].

体内実験

Selatogrel (0-0.1 mg/kg, i.v., single dosage) dose-dependently blocks thrombus formation in the wistar rat FeCl3 model and causes less surgical blood loss[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: FeCl3 induced arterial injury in wistar rats[1]
Dosage: 0-0.1 mg/kg
Administration: i.v., 5 minutes before arterial injury
Result: Prevented the FeCl3-induced thrombotic occlusions in a dose-dependent manner with minimal observed surgical blood loss of 0.4 g.
臨床実験
分子量

618.62

分子式

C28H39N6O8P
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N1CCN(CC1)C(OCCCC)=O)[C@H](CP(O)(O)=O)NC(C2=CC(N3C[C@H](CC3)OC)=NC(C4=CC=CC=C4)=N2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (161.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6165 mL 8.0825 mL 16.1650 mL
5 mM 0.3233 mL 1.6165 mL 3.2330 mL
10 mM 0.1617 mL 0.8083 mL 1.6165 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.04 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6165 mL 8.0825 mL 16.1650 mL 40.4125 mL
5 mM 0.3233 mL 1.6165 mL 3.2330 mL 8.0825 mL
10 mM 0.1617 mL 0.8083 mL 1.6165 mL 4.0413 mL
15 mM 0.1078 mL 0.5388 mL 1.0777 mL 2.6942 mL
20 mM 0.0808 mL 0.4041 mL 0.8083 mL 2.0206 mL
25 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6165 mL
30 mM 0.0539 mL 0.2694 mL 0.5388 mL 1.3471 mL
40 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
50 mM 0.0323 mL 0.1617 mL 0.3233 mL 0.8083 mL
60 mM 0.0269 mL 0.1347 mL 0.2694 mL 0.6735 mL
80 mM 0.0202 mL 0.1010 mL 0.2021 mL 0.5052 mL
100 mM 0.0162 mL 0.0808 mL 0.1617 mL 0.4041 mL
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Selatogrel Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Selatogrel1159500-34-1ACT-246475ACT246475ACT 246475P2Y ReceptorthrombosisInhibitorinhibitorinhibit

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製品名:
Selatogrel
製品番号:
HY-109122
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