1159500-34-1
Chemical Structure
Selatogrel
Synonym(s): ACT-246475
- CAS No.: 1159500-34-1
- Formula:C28H39N6O8P
- Molecular Weight:618.62
IUPAC Name: ((R)-3-(4-(butoxycarbonyl)piperazin-1-yl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxamido)-3-oxopropyl)phosphonic acid
InChIKey: FYXHWMQPCJOJCH-GMAHTHKFSA-N
SMILES: O=C(N1CCN(CC1)C(OCCCC)=O)[C@H](CP(O)(O)=O)NC(C2=CC(N3C[C@H](CC3)OC)=NC(C4=CC=CC=C4)=N2)=O
Biological Activity: Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Selatogrel | 99.75% | Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy. | ||||||||||||||||||||
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Selatogrel (Standard) | ≥98% | Selatogrel (Standard) is the analytical standard of Selatogrel (HY-109122). This product is intended for research and analytical applications. Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy. | ||||||||||||||||||||
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- [1]. Caroff E, et al., 4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. J Med Chem. 2015 Dec 10;58(23):9133-53. [Content Brief]
Keywords
