Selatogrel hydrochloride
Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy.
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- CAS No.: 2210298-04-5
- Formule: C28H40ClN6O8P
- Masse moléculaire:655.08
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
P2Y12 Receptor |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FeCl3 induced arterial injury in wistar rats[1]
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Dosage:0-0.1 mg/kg
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Administration:i.v., 5 minutes before arterial injury
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Result:Prevented the FeCl3-induced thrombotic occlusions in a dose-dependent manner with minimal observed surgical blood loss of 0.4 g.
Chemical Information
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CAS No. 2210298-04-5
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Masse moléculaire 655.08
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Formule C28H40ClN6O8P
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SMILES
O=C(N1CCN(CC1)C(OCCCC)=O)[C@H](CP(O)(O)=O)NC(C2=CC(N3C[C@H](CC3)OC)=NC(C4=CC=CC=C4)=N2)=O.Cl
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Synonyms
ACT-246475 hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
[1]. Caroff E, et al., 4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. J Med Chem. 2015 Dec 10;58(23):9133-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Selatogrel hydrochloride Related Classifications
HY-109122A Related Classifications
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