Selatogrel hydrochloride
Selatogrel (ACT-246475) is a reversible and selective P2Y12 receptor antagonist which inhibits platelet aggregation with an IC50 of 8 nM. Selatogrel exhibits antithrombotic efficacy.
For research use only. We do not sell to patients.
- CAS No.: 2210298-04-5
- Formula: C28H40ClN6O8P
- Molecular Weight:655.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All P2Y Receptor Isoforms
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Biological Activity
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P2Y12 Receptor |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FeCl3 induced arterial injury in wistar rats[1]
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Dosage:0-0.1 mg/kg
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Administration:i.v., 5 minutes before arterial injury
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Result:Prevented the FeCl3-induced thrombotic occlusions in a dose-dependent manner with minimal observed surgical blood loss of 0.4 g.
Chemical Information
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CAS No. 2210298-04-5
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Molecular Weight 655.08
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Formula C28H40ClN6O8P
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SMILES
O=C(N1CCN(CC1)C(OCCCC)=O)[C@H](CP(O)(O)=O)NC(C2=CC(N3C[C@H](CC3)OC)=NC(C4=CC=CC=C4)=N2)=O.Cl
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Synonyms
ACT-246475 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Caroff E, et al., 4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel. J Med Chem. 2015 Dec 10;58(23):9133-53. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Selatogrel hydrochloride Related Classifications
HY-109122A Related Classifications
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