Talaporfin sodium
Based on 4 publication(s) in Google Scholar
Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT).
For research use only. We do not sell to patients.
- Purity: 96.72%
- CAS No.: 220201-34-3
- Formula: C38H37N5Na4O9
- Molecular Weight:799.69
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Talaporfin sodium
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Biological Activity
Labeling in vivo:
1. Use the rat brain tumor model produced by the inoculation of resuspended tumor cells into the frontal rat brain. Feed animals according to your normal protocol.
2. Intravenous injection of 5 mg/kg body weight talaporfin sodium, the concentration of the talaporfin sodium is 5 mg/1 ml 0.9% saline.
3. For the control group, intraperitoneal injection of 100 mg/kg body weight 5-ALA, the concentration of the 5-ALA is 20 mg/1 ml 0.9% saline.
4. Obtain the tissue samples corresponding to the tumor (or edema) brain tissue with 5 mm thickness.
5. The samples are well homogenized with 1 ml of 100% dimethyl sulfoxide (DMSO) and the 100 ul aliquots of the supernatant are put into each well of a 96-well plate.
6. Measure the relative fluorescence intensities of the samples by using a microplate readerin emission wavelength of 670 ±10 nm. The relative fluorescence intensities of the samples (a.u.) were normalized to the relative fluorescence intensities per 1 g-weight of the samples (a.u.).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rat brain tumor model[1]
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Dosage:5 mg/kg
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Administration:Intravenous injection
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Result:Showed high fluorescence intensity and retention in brain tumor differentiated from vasogenic edema.
Chemical Information
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CAS No. 220201-34-3
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Appearance Solid
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Molecular Weight 799.69
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Formula C38H37N5Na4O9
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Color Purple to black
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SMILES
O=C(O[Na])C[C@@H](C(O[Na])=O)NC(C/C1=C2[C@@H](CCC(O[Na])=O)[C@H](C)C(/C=C3C(C)=C(C=C)/C(N/3)=C/C(C(C)=C/4CC)=NC4=C/C5=C(C)C(C(O[Na])=O)=C1N5)=N\2)=O
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Synonyms
ME2906; Mono-L-aspartyl chlorin e6; NPe6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Biomed Pharmacother
2024 Jul:176:116768. PMID: 38795638 -
Solvent & Solubility
H2O : 20 mg/mL (25.01 mM; Need ultrasonic)
DMSO : 2 mg/mL (2.50 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (284 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 1.2505 mL | 6.2524 mL | 12.5048 mL | 31.2621 mL |
| H2O | 5 mM | 0.2501 mL | 1.2505 mL | 2.5010 mL | 6.2524 mL |
| 10 mM | 0.1250 mL | 0.6252 mL | 1.2505 mL | 3.1262 mL | |
| 15 mM | 0.0834 mL | 0.4168 mL | 0.8337 mL | 2.0841 mL | |
| 20 mM | 0.0625 mL | 0.3126 mL | 0.6252 mL | 1.5631 mL | |
| 25 mM | 0.0500 mL | 0.2501 mL | 0.5002 mL | 1.2505 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Talaporfin sodium Related Classifications
HY-16477 Related Classifications
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