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Cat. No.: HY-16477A

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Talaporfin

(Synonyms: ME2906 free acid; Mono-L-aspartyl chlorin e6 free acid; NPe6 free acid)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Talaporfin sodium, can be used in intraoperative photodynamic therapy (PDT) with a 664-nm semiconductor laser, was evaluated for efficacy and safety in treating primary malignant parenchymal brain tumors.

For research use only. We do not sell to patients.

CAS No.: 110230-98-3
Formula: C₃₈H₄₁N₅O₉
Molecular Weight:711.76

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

Talaporfin Chemical Structure

CAS No.: 110230-98-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- Clinical Trial
Chemical Information
Publications (4)
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	181 μM Compound: Talaporfin	Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay Dark toxicity in human A549 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay	[PMID: 33744687]
A549	IC₅₀	256 μM Compound: Talaporfin	Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32846322]
A549	IC₅₀	6.21 μM Compound: Talaporfin	Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay Phototoxicity in human A549 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay	[PMID: 33744687]
A549	IC₅₀	8.73 μM Compound: Talaporfin	Phototoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay Phototoxicity against human A549 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay	[PMID: 32846322]
B16-F10	IC₅₀	14 μM Compound: Talaporfin	Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay Phototoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay	[PMID: 32846322]
B16-F10	IC₅₀	16.43 μM Compound: Talaporfin	Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay	[PMID: 37690263]
B16-F10	IC₅₀	276.2 μM Compound: Talaporfin	Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under dark condition by CCK-8 assay Cytotoxicity against mouse B16-F10 cells incubated for 48 hrs under dark condition by CCK-8 assay	[PMID: 37690263]
B16-F10	IC₅₀	303 μM Compound: Talaporfin	Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against mouse B16-F10 cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32846322]
HCT-116	IC₅₀	2.95 μM Compound: Talaporfin	Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay Phototoxicity in human HCT-116 cells assessed as reduction in cell viability irradiated 10 j/cm2 for 24 hrs followed by incubated for 24 hrs by CCK8 assay	[PMID: 33744687]
HCT-116	IC₅₀	50.72 μM Compound: Talaporfin	Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay Dark toxicity in human HCT-116 cells assessed as reduction in cell viability incubated under dark for 48 hrs measured after 48 hrs by CCK8 assay	[PMID: 33744687]
HeLa	IC₅₀	>300 μM Compound: Talaporfin	Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 48 hrs by CCK-8 assay	[PMID: 32846322]
HeLa	IC₅₀	5.92 μM Compound: Talaporfin	Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay Phototoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by irradiated with 10 J/cm2 660 nanometer visible light and measured after 24 hrs hrs by CCK-8 assay	[PMID: 32846322]
HepG2	IC₅₀	>300 μM Compound: Talaporfin	Cytotoxicity against human HepG2 cells incubated for 48 hrs under dark condition by CCK-8 assay Cytotoxicity against human HepG2 cells incubated for 48 hrs under dark condition by CCK-8 assay	[PMID: 37690263]
HepG2	IC₅₀	8.9 μM Compound: Talaporfin	Cytotoxicity against human HepG2 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay Cytotoxicity against human HepG2 cells incubated for 48 hrs under 10 J/cm2 light irradiation at 660 nm by CCK-8 assay	[PMID: 37690263]

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 110230-98-3
Molecular Weight 711.76
Formula C₃₈H₄₁N₅O₉
SMILES

O=C(O)C[C@@H](C(O)=O)NC(C/C1=C2[C@@H](CCC(O)=O)[C@H](C)C(/C=C3C(C)=C(C=C)/C(N/3)=C/C(C(C)=C/4CC)=NC4=C/C5=C(C)C(C(O)=O)=C1N5)=N\2)=O
Synonyms

ME2906 free acid; Mono-L-aspartyl chlorin e6 free acid; NPe6 free acid
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Journal Impact Factor

Adv Funct Mater

09 September 2021.
Chemrxiv

2025 Aug 28.
Biomed Pharmacother

Repurposing anti-cancer porphyrin derivative drugs to target SARS-CoV-2 envelope. [Abstract]

2024 Jul:176:116768. PMID: 38795638
Patent

US20230365577A1.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Phase II clinical study on intraoperative photodynamic therapy with talaporfin sodium and semiconductor laser in patients with malignant brain tumors

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- Clinical Trial
Chemical Information
Publications (4)
Purity & Documentation
References

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Talaporfin

Publications Citing Use of MedChemExpress (MCE) Talaporfin