1. Epigenetics
    Apoptosis
  2. Histone Acetyltransferase
    Apoptosis
  3. TH1834 dihydrochloride

TH1834 dihydrochloride 

Cat. No.: HY-123604A Purity: 99.68%
Handling Instructions

TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity.

For research use only. We do not sell to patients.

TH1834 dihydrochloride Chemical Structure

TH1834 dihydrochloride Chemical Structure

CAS No. : 2108830-09-5

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 226 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2050 Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of TH1834 dihydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TH1834 dihydrochloride is a specific Tip60 (KAT5) histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1].

In Vitro

TH1834 dihydrochloride (0-500 μM; 1 hour; MCF7 cells) treatment significantly reduces the viability of MCF7 cells[1].
TH1834 dihydrochloride (0-500 μM; 1 hour; MCF7 cells) treatment highly significant increase in cytotoxicity[1].
TH1834 dihydrochloride (500 μM; 1 hour; MCF7 cells) treatment induces caspase 3 activation in MCF7 cells[1].
TH1834 dihydrochloride significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage in breast cancer[1].

Cell Viability Assay[1]

Cell Line: MCF7 cells
Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM
Incubation Time: 1 hour
Result: Significantly reduced the viability of MCF7 cells.

Cell Cytotoxicity Assay[1]

Cell Line: MCF7 cells
Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM
Incubation Time: 1 hour
Result: Highly significant increase in cytotoxicity at all concentrations used.

Western Blot Analysis[1]

Cell Line: MCF7 cells
Concentration: 500 μM
Incubation Time: 1 hour
Result: Marked caspase 3 activation was observed in MCF7 cells in an independent assay.
Molecular Weight

641.63

Formula

C₃₃H₄₂Cl₂N₆O₃

CAS No.

2108830-09-5

SMILES

O=C(O)CN1N=C(C2=CC=C(CN(CCC3=CC=CC=C3)CCCCOC4=CC=C(CN5CCCC5)C=C4)C=C2)N=N1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (389.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5585 mL 7.7927 mL 15.5853 mL
5 mM 0.3117 mL 1.5585 mL 3.1171 mL
10 mM 0.1559 mL 0.7793 mL 1.5585 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.24 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.24 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.24 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TH1834TH 1834TH-1834Histone AcetyltransferaseApoptosisHATsHATTip60DNAdamageapoptosisbreastcancerPNTcaspase-3cytotoxicityInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TH1834 dihydrochloride
Cat. No.:
HY-123604A
Quantity:
MCE Japan Authorized Agent: