1. Epigenetics
    Apoptosis
  2. Histone Acetyltransferase
    Apoptosis
  3. TH1834 dihydrochloride

TH1834 dihydrochloride 

Cat. No.: HY-123604A
Handling Instructions

TH1834 dihydrochloride is a specific Tip60 histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity.

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TH1834 dihydrochloride Chemical Structure

TH1834 dihydrochloride Chemical Structure

CAS No. : 2108830-09-5

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Description

TH1834 dihydrochloride is a specific Tip60 histone acetyltransferase inhibitor. TH1834 dihydrochloride induces apoptosis and increases DNA damage in breast cancer. TH1834 dihydrochloride does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1].

In Vitro

TH1834 (0-500 μM; 1 hour; MCF7 cells) treatment significantly reduces the viability of MCF7 cells[1].
TH1834 (0-500 μM; 1 hour; MCF7 cells) treatment highly significant increase in cytotoxicity[1].
TH1834 (500 μM; 1 hour; MCF7 cells) treatment induces caspase 3 activation in MCF7 cells[1].
TH1834 significantly inhibits Tip60 activity in vitro and treating cells with TH1834 results in apoptosis and increased unrepaired DNA damage in breast cancer[1].

Cell Viability Assay[1]

Cell Line: MCF7 cells
Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM
Incubation Time: 1 hour
Result: Significantly reduced the viability of MCF7 cells.

Cell Cytotoxicity Assay[1]

Cell Line: MCF7 cells
Concentration: 0 μM, 0.5 μM, 5 μM, 50 μM and 500 μM
Incubation Time: 1 hour
Result: Highly significant increase in cytotoxicity at all concentrations used.

Western Blot Analysis[1]

Cell Line: MCF7 cells
Concentration: 500 μM
Incubation Time: 1 hour
Result: Marked caspase 3 activation was observed in MCF7 cells in an independent assay.
Molecular Weight

641.63

Formula

C₃₃H₄₂Cl₂N₆O₃

CAS No.

2108830-09-5

SMILES

O=C(O)CN1N=C(C2=CC=C(CN(CCC3=CC=CC=C3)CCCCOC4=CC=C(CN5CCCC5)C=C4)C=C2)N=N1.[H]Cl.[H]Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TH1834TH 1834TH-1834Histone AcetyltransferaseApoptosisHATsHATTip60DNAdamageapoptosisbreastcancerPNTcaspase-3cytotoxicityInhibitorinhibitorinhibit

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TH1834 dihydrochloride
Cat. No.:
HY-123604A
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