2. Anti-infection
  3. Antibiotic Bacterial
  4. Ticarcillin

Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research.

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Ticarcillin

Ticarcillin 構造式

CAS 番号 : 34787-01-4

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Ticarcillin 関連抗体

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製品説明

Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research[1][2][3].

IC50 & Target

β-lactam

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
233 3
Compound: Ticarcillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
CHO IC50
233 3
Compound: Ticarcillin
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
Inhibition of mouse OAT3 expressed in CHO cells assessed as inhibition of fluorescein uptake over 20 mins
[PMID: 23344796]
体外実験

Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ticarcillin 関連抗体

Cell Viability Assay[2]

Cell Line: Ps. aeruginosa
Concentration: 10 mg/L
Incubation Time: 18 hours
Result: Showed the MIC for Ticarcillin against strain between 6.3-12.5 mg/L.
体内実験

Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect[2].
Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss type male mice injected with Ps. aeruginosa[2]
Dosage: 50, 100, 200 mg/kg
Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once
Result: Increased effect significantly (0.001 < P < 0.0025) with increasing dose.
Animal Model: Swiss type male mice injected with Ps. aeruginosa[2]
Dosage: 50, 100, 200 mg/kg
Administration: Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:
Dose (mg/kg) AUCa (mg/kg) Kelb (h-1) T1/2 (min)
Ticarcillin 50 8.76 (0.72) 1.57 (0.18) 26
100 26.14 (0.60) 1.53 (0.11) 27
200 54.56 (2.90) 1.47 (0.12) 28
分子量

384.43

分子式

C15H16N2O6S2
CAS 番号
SMILES

OC([C@H](C1=CSC=C1)C(N[C@H]2[C@]3([H])N(C2=O)[C@H](C(C)(S3)C)C(O)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Ticarcillin Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ticarcillin34787-01-4AntibioticBacterialantibacterial agentgram-negative bacteriaATCC 27853Ps. aeruginosaInhibitorinhibitorinhibit

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製品名:
Ticarcillin
製品番号:
HY-139805
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