2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Toremifene

Toremifene  (Synonyms: Z-Toremifene; NK 622 free base; FC-1157a free base)

製品番号: HY-B0005A 純度: 99.73%
COA 取扱説明書 Technical Support

Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively.

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Toremifene

Toremifene 構造式

CAS 番号 : 89778-26-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Solid
10 mg $50 在庫あり
25 mg $90 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 7 publication(s) in Google Scholar

Other Forms of Toremifene:

Toremifene 関連抗体

Top Publications Citing Use of Products

Estrogen Receptor/ERR アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

Toremifene (Z-Toremifene) is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively[1][2].

Cellular Effect
Cell Line Type Value Description References
A549 EC50
0.09 μM
Compound: toremifene
Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
Inhibition of pseudotyped HIV/EBOV GP infected in human A549 cells assessed as reduction in virus entry measured after 48 hrs by luciferase reporter gene assay
[PMID: 32490678]
HEK-293T CC50
17 μM
Compound: Tor
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against HEK293T cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
[PMID: 38889610]
HEK-293T EC50
62.8 nM
Compound: toremifene
Inhibition of HIV/EBOV GP T519V mutant infected in 293T cells assessed as reduction in virus entry
Inhibition of HIV/EBOV GP T519V mutant infected in 293T cells assessed as reduction in virus entry
[PMID: 32490678]
HEK-293T EC50
62.8 nM
Compound: toremifene
Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entry
Inhibition of HIV/EBOV GP Y517S mutant infected in 293T cells assessed as reduction in virus entry
[PMID: 32490678]
HeLa CC50
> 100 μM
Compound: Toremifene
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs by MTS assay
[PMID: 37021830]
HeLa EC50
0.67 μM
Compound: toremifene
Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
Antiviral activity against Ebola virus 1976 Mayinga infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
[PMID: 32490678]
HeLa EC50
3.25 μM
Compound: toremifene
Antiviral activity against Marburg virus Lake Victoria, 2005 Angola infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
Antiviral activity against Marburg virus Lake Victoria, 2005 Angola infected in human HeLa cells pretreated for 1 hr followed by virus infection measured after 24 hrs by Hoechst staining-based immunofluorescence assay
[PMID: 32490678]
Huh-7 CC50
9.31 μM
Compound: 9
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by cellular ATP method
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by cellular ATP method
[PMID: 35872393]
MCF-10A IC50
> 100 μM
Compound: Toremifene
Cytotoxicity against human MCF10A cells by MTT assay
Cytotoxicity against human MCF10A cells by MTT assay
[PMID: 31546197]
MCF7 IC50
7 μM
Compound: Toremifene
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
[PMID: 31546197]
MDA-MB-231 IC50
13 μM
Compound: Toremifene
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
Antiproliferative activity against human MDA-MB-231 cells by MTT assay
[PMID: 31546197]
Vero CC50
10.11 μM
Compound: Toremiphene
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
Cell viability measured by CellTiter-Glo assay in Vero cells at MOI 0.05 after 72hr
10.1101/2020.03.20.999730
Vero IC50
3.58 μM
Compound: Toremiphene
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
Antiviral activity against SARS-CoV-2 (viral titer) measured by plaque assay in Vero cells at MOI 0.0125 after 24 hr
10.1101/2020.03.20.999730
Vero C1008 IC50
0.162 μM
Compound: Toremifene
Antiviral activity against Ebolavirus infected in african green monkey Vero E6 cells assessed as reduction in virus entry after 48 hrs by by Celltiter-Glo luminescent assay
Antiviral activity against Ebolavirus infected in african green monkey Vero E6 cells assessed as reduction in virus entry after 48 hrs by by Celltiter-Glo luminescent assay
[PMID: 29272110]
Vero C1008 IC50
0.162 μM
Compound: Toremifene
Antiviral activity against Ebolavirus expressing eGFP infected in African green monkey Vero E6 cells assessed as inhibition of viral replication after 48 hrs by spectrofluorometric method
Antiviral activity against Ebolavirus expressing eGFP infected in African green monkey Vero E6 cells assessed as inhibition of viral replication after 48 hrs by spectrofluorometric method
[PMID: 29741894]
体外実験

Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis and other adverse effects resulting from ADT with prostate cancer[1].
The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Toremifene 関連抗体
体内実験

The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

405.96

分子式

C26H28ClNO
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=CC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (123.16 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4633 mL 12.3165 mL 24.6330 mL
5 mM 0.4927 mL 2.4633 mL 4.9266 mL
10 mM 0.2463 mL 1.2316 mL 2.4633 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.73%

COA (247 KB) HNMR (255 KB) LCMS (103 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4633 mL 12.3165 mL 24.6330 mL 61.5824 mL
5 mM 0.4927 mL 2.4633 mL 4.9266 mL 12.3165 mL
10 mM 0.2463 mL 1.2316 mL 2.4633 mL 6.1582 mL
15 mM 0.1642 mL 0.8211 mL 1.6422 mL 4.1055 mL
20 mM 0.1232 mL 0.6158 mL 1.2316 mL 3.0791 mL
25 mM 0.0985 mL 0.4927 mL 0.9853 mL 2.4633 mL
30 mM 0.0821 mL 0.4105 mL 0.8211 mL 2.0527 mL
40 mM 0.0616 mL 0.3079 mL 0.6158 mL 1.5396 mL
50 mM 0.0493 mL 0.2463 mL 0.4927 mL 1.2316 mL
60 mM 0.0411 mL 0.2053 mL 0.4105 mL 1.0264 mL
80 mM 0.0308 mL 0.1540 mL 0.3079 mL 0.7698 mL
100 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
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Toremifene Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Toremifene89778-26-7Z-ToremifeneNK 622FC-1157aNK622NK-622Estrogen Receptor/ERRInhibitorinhibitorinhibit

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製品名:
Toremifene
製品番号:
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