Vonoprazan hydrochloride (Synonyms: TAK-438 hydrochloride)

Name: Vonoprazan hydrochloride
Brand: MedChemExpress
SKU: HY-100007A
Rating: 5.0 (6 reviews)

Cat. No.: HY-100007A Pureté: 99.41%: Fiche technique
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Vonoprazan hydrochloride, a proton pump inhibitor (PPI), is a potent and orally active potassium-competitive acid blocker (P-CAB), with antisecretory activity. Vonoprazan hydrochloride inhibits H⁺,K⁺-ATPase activity in porcine gastric microsomes with an IC₅₀ of 19 nM at pH 6.5. Vonoprazan hydrochloride is developed for the research of acid-related diseases, such as gastroesophageal reflux disease and peptic ulcer disease. Vonoprazan hydrochloride can be used for eradication of Helicobacter pylori.

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Vonoprazan hydrochloride Chemical Structure

CAS No. : 1957202-44-6

Size	Stock	Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Solid
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Based on 6 publication(s) in Google Scholar

Other Forms of Vonoprazan hydrochloride:

Vonoprazan In-stock
Vonoprazan Fumarate In-stock

6 Publications Citing Use of MCE Vonoprazan hydrochloride

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique
Pureté et documentation
Références
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Description

IC₅₀ & Target

IC₅₀: 19 nM (porcine gastric H⁺,K⁺-ATPase, at pH 6.5)^[2]

In Vitro

Vonoprazan (0.1 nM-10 μM; 30 minutes) exhibits porcine gastric H⁺, K⁺-ATPase activity in a concentration-dependent manner^[2].
Vonoprazan does not inhibit Na⁺,K⁺-ATPase activity, even at concentrations 500 times higher than their IC₅₀ values against gastric H⁺,K⁺-ATPase activity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vonoprazan (1-4 mg/kg; p.o.) completely inhibits basal and 2-deoxy-D-glucose (200 mg/kg; s.c.)-stimulated gastric acid secretion at the 4 mg/kg dose in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male 7- or 8-week-old Sprague-Dawley rat^[2]
Dosage:	0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg
Administration:	Oral administration
Result:	Inhibited basal gastric acid secretion in a dose-dependent manner.

Masse moléculaire

381.85

Formule

C₁₇H₁₇ClFN₃O₂S

CAS No.

1957202-44-6

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=CC=CN=C1)(N2C=C(CNC)C=C2C3=C(F)C=CC=C3)=O.Cl

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (261.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6188 mL	13.0941 mL	26.1883 mL
5 mM	0.5238 mL	2.6188 mL	5.2377 mL
10 mM	0.2619 mL	1.3094 mL	2.6188 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.41%

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Fiche technique (282 KB) SDS (252 KB)

COA (259 KB) HNMR (441 KB) RP-HPLC (257 KB) LCMS (97 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Arikawa Y, et al. Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem, 2012, 55(9), 4446-4456. [Content Brief]

[2]. Hori Y, et al. 1-[5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel and potent potassium-competitive acid blocker for the treatment of acid-related diseases. J Pharmacol Exp Ther, 2010, 335(1), 231-238. [Content Brief]

[3]. Sugimoto M, et al. Role of Vonoprazan in Helicobacter pylori Eradication Therapy in Japan. Front Pharmacol. 2019 Jan 15;9:1560. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6188 mL	13.0941 mL	26.1883 mL	65.4707 mL
	5 mM	0.5238 mL	2.6188 mL	5.2377 mL	13.0941 mL
	10 mM	0.2619 mL	1.3094 mL	2.6188 mL	6.5471 mL
	15 mM	0.1746 mL	0.8729 mL	1.7459 mL	4.3647 mL
	20 mM	0.1309 mL	0.6547 mL	1.3094 mL	3.2735 mL
	25 mM	0.1048 mL	0.5238 mL	1.0475 mL	2.6188 mL
	30 mM	0.0873 mL	0.4365 mL	0.8729 mL	2.1824 mL
	40 mM	0.0655 mL	0.3274 mL	0.6547 mL	1.6368 mL
	50 mM	0.0524 mL	0.2619 mL	0.5238 mL	1.3094 mL
	60 mM	0.0436 mL	0.2182 mL	0.4365 mL	1.0912 mL
	80 mM	0.0327 mL	0.1637 mL	0.3274 mL	0.8184 mL
	100 mM	0.0262 mL	0.1309 mL	0.2619 mL	0.6547 mL

Vonoprazan hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Vonoprazan hydrochloride (Synonyms: TAK-438 hydrochloride)

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Other Forms of Vonoprazan hydrochloride:

Vonoprazan hydrochloride Related Antibodies

6 Publications Citing Use of MCE Vonoprazan hydrochloride

Recommandations en vedette

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Activité biologique

Pureté et documentation

Références

Avis client

Vonoprazan hydrochloride Related Antibodies

Calculateur de molarité

Calculateur de dilution

Complete Stock Solution Preparation Table

Vonoprazan hydrochloride Related Classifications

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