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  3. Endogenous Metabolite
  4. β-Nicotinamide mononucleotide, reduced form disodium

β-Nicotinamide mononucleotide, reduced form disodium  (Synonyms: NMNH disodium)

製品番号: HY-W615108B 純度: 99.55%
COA 取扱説明書 Technical Support

β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is an orally active reduced version of β-Nicotinamide mononucleotide (HY-F0004). β-Nicotinamide mononucleotide, reduced form disodium can significantly increase the levels of NAD+ and NADH, inhibit glycolysis, the tricarboxylic acid cycle, and cell growth, with its effects being dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT).

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β-Nicotinamide mononucleotide, reduced form disodium

β-Nicotinamide mononucleotide, reduced form disodium 構造式

CAS 番号 : 108347-85-9

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 121 在庫あり
Solution
10 mM * 1 mL in Water USD 121 在庫あり
Solid
5 mg $110 在庫あり
10 mg $155 在庫あり
25 mg $260 在庫あり
50 mg $370 在庫あり
100 mg $520 在庫あり
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β-Nicotinamide mononucleotide, reduced form disodium 関連抗体

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製品説明

β-Nicotinamide mononucleotide, reduced form (NMNH) disodium is an orally active reduced version of β-Nicotinamide mononucleotide (HY-F0004). β-Nicotinamide mononucleotide, reduced form disodium can significantly increase the levels of NAD+ and NADH, inhibit glycolysis, the tricarboxylic acid cycle, and cell growth, with its effects being dependent on nicotinamide mononucleotide adenylyltransferase (NMNAT)[1][2].

体外実験

β-Nicotinamide mononucleotide, reduced form (100 μM; 12 h) disodium can significantly increase the level of NAD+ in HepG2 cells and reduce the levels of glycolysis and TCA cycle intermediates[1].
β-Nicotinamide mononucleotide, reduced form (250-1000 μM; 12-72 h) disodium can inhibit the growth of HepG2 cells and induce cell cycle arrest[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Nicotinamide mononucleotide, reduced form disodium 関連抗体

Cell Viability Assay[1]

Cell Line: HepG2 cells
Concentration: 10, 50, 100, 250 and 500 μM
Incubation Time: 72 h
Result: Inhibited HepG2 cell growth at concentrations higher than 250 μM.
体内実験

β-Nicotinamide mononucleotide, reduced form (340 mg/kg; intraperitoneal injection/oral gavage; single dose) disodium can increase the NAD+ level in the liver of male mice[1].
β-Nicotinamide mononucleotide, reduced form (250 mg/kg; intraperitoneal injection; single dose) disodium can increase the NAD+ levels by 2-5 times in tissues such as the liver, kidney, brain, muscle, and whole blood of C57BL/6J mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

380.20

分子式

C11H15N2Na2O8P
CAS 番号
Appearance

Solid

Color

Light yellow to yellow

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=C(CC=C2)C(N)=O)O[C@@H]1COP(O[Na])(O[Na])=O
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

H2O : ≥ 100 mg/mL (263.02 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6302 mL 13.1510 mL 26.3019 mL
5 mM 0.5260 mL 2.6302 mL 5.2604 mL
10 mM 0.2630 mL 1.3151 mL 2.6302 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.55%

COA (254 KB) HNMR (269 KB) CNMR (229 KB) RP-HPLC (251 KB) MS (72 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.6302 mL 13.1510 mL 26.3019 mL 65.7549 mL
5 mM 0.5260 mL 2.6302 mL 5.2604 mL 13.1510 mL
10 mM 0.2630 mL 1.3151 mL 2.6302 mL 6.5755 mL
15 mM 0.1753 mL 0.8767 mL 1.7535 mL 4.3837 mL
20 mM 0.1315 mL 0.6575 mL 1.3151 mL 3.2877 mL
25 mM 0.1052 mL 0.5260 mL 1.0521 mL 2.6302 mL
30 mM 0.0877 mL 0.4384 mL 0.8767 mL 2.1918 mL
40 mM 0.0658 mL 0.3288 mL 0.6575 mL 1.6439 mL
50 mM 0.0526 mL 0.2630 mL 0.5260 mL 1.3151 mL
60 mM 0.0438 mL 0.2192 mL 0.4384 mL 1.0959 mL
80 mM 0.0329 mL 0.1644 mL 0.3288 mL 0.8219 mL
100 mM 0.0263 mL 0.1315 mL 0.2630 mL 0.6575 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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β-Nicotinamide mononucleotide, reduced form disodium Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Nicotinamide mononucleotide, reduced form disodium108347-85-9NMNH disodiumEndogenous MetabolitemiceHepG2NAD+NADHInhibitorinhibitorinhibit

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