2′-Deoxyadenosine 5′-monophosphate disodium

Name: 2′-Deoxyadenosine 5′-monophosphate disodium
Brand: MedChemExpress
SKU: HY-W105272
Rating: 4.5 (0 reviews)

Cat. No.: HY-W105272 Pureza: 99.31%: Ficha de datos
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2′-Deoxyadenosine 5′-monophosphate disodium, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate disodium can be used to study adenosine-based interactions during DNA synthesis and DNA damage.

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2′-Deoxyadenosine 5′-monophosphate disodium Estructura química

No. CAS : 2922-74-9

Tamaño	Stock	Cantidad
Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
Muestra gratis (0.1 - 0.2 mg)	Solicite ahora
100 mg	En stock	Estimated Time of Arrival: December 31
250 mg	En stock	Estimated Time of Arrival: December 31
500 mg	Obtener un presupuesto
1 g	Obtener un presupuesto

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Other Forms of 2′-Deoxyadenosine 5′-monophosphate disodium:

2'-Deoxyadenosine-5'-monophosphate In-stock
2′-Deoxyadenosine 5′-monophosphate-¹³C₁₀,¹⁵N₅ disodium Obtener un presupuesto
2′-Deoxyadenosine 5′-monophosphate disodium (Standard) Obtener un presupuesto

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Referencias
Revisión del cliente

Descripciòn

IC₅₀ & Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro

2′-Deoxyadenosine 5′-monophosphate (dAMP) is incorporated into Caco-2 cells in a time-dependent manner. The uptake of 2′-Deoxyadenosine 5′-monophosphate is increased with a drop in pH, suggesting that 2′-Deoxyadenosine 5′-monophosphate transport activity might be linked to the protons. 2′-Deoxyadenosine 5′-monophosphate uptake by Caco-2 cells is pH- and Na+-dependent^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Peso molecular

375.19

Fòrmula

C₁₀H₁₂N₅Na₂O₆P

No. CAS

2922-74-9

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O[Na])(O[Na])=O

Structure Classification

Others

Initial Source

Endogenous metabolite

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (266.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (133.27 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6653 mL	13.3266 mL	26.6532 mL
5 mM	0.5331 mL	2.6653 mL	5.3306 mL
10 mM	0.2665 mL	1.3327 mL	2.6653 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Pureza y Documentación

Purity: 99.31%

Select Batch:

Ficha de datos (277 KB) SDS (393 KB)

COA (254 KB) HNMR (252 KB) RP-HPLC (257 KB) MS (69 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Katsuya Narumi, et al. Mutual role of ecto-5'-nucleotidase/CD73 and concentrative nucleoside transporter 3 in the intestinal uptake of dAMP. PLoS One. 2019 Oct 21;14(10):e0223892. [Content Brief]

[2]. V Duarte, et al. Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. Nucleic Acids Res. 1999 Jan 15;27(2):496-502. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.6653 mL	13.3266 mL	26.6532 mL	66.6329 mL
	5 mM	0.5331 mL	2.6653 mL	5.3306 mL	13.3266 mL
	10 mM	0.2665 mL	1.3327 mL	2.6653 mL	6.6633 mL
	15 mM	0.1777 mL	0.8884 mL	1.7769 mL	4.4422 mL
	20 mM	0.1333 mL	0.6663 mL	1.3327 mL	3.3316 mL
	25 mM	0.1066 mL	0.5331 mL	1.0661 mL	2.6653 mL
	30 mM	0.0888 mL	0.4442 mL	0.8884 mL	2.2211 mL
	40 mM	0.0666 mL	0.3332 mL	0.6663 mL	1.6658 mL
	50 mM	0.0533 mL	0.2665 mL	0.5331 mL	1.3327 mL
	60 mM	0.0444 mL	0.2221 mL	0.4442 mL	1.1105 mL
	80 mM	0.0333 mL	0.1666 mL	0.3332 mL	0.8329 mL
	100 mM	0.0267 mL	0.1333 mL	0.2665 mL	0.6663 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.